TRIM7 tripartite motif containing 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM7provided by HGNC
Official Full Name: tripartite motif containing 7provided by HGNC
Primary source: HGNC:HGNC:16278
See related: Ensembl:ENSG00000146054 MIM:609315; AllianceGenome:HGNC:16278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GNIP; RNF90
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression: Biased expression in skin (RPKM 5.6), esophagus (RPKM 2.8) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (181193924..181205196, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (181753960..181778284, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (180620924..180632196, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11.
Title: The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11.
TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-beta signaling pathway.
Title: TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway.
Study on the expression of TRIM7 in peripheral blood mononuclear cells of patients with sepsis and its early diagnostic value.
Title: Study on the expression of TRIM7 in peripheral blood mononuclear cells of patients with sepsis and its early diagnostic value.
A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Title: A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells.
Title: TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells.
GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer.
Title: GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer.
TRIM7 suppresses cell invasion and migration through inhibiting HIF-1alpha accumulation in clear cell renal cell carcinoma.
Title: TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma.
TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Title: TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Title: Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein.
Title: The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of tripartite motif containing 7 (TRIM7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

PMC156606P1 (e-PCR)
- UniSTS:271408

PMC156606P2 (e-PCR)
- UniSTS:271409

PMC156606P3 (e-PCR)
- UniSTS:271410

D8S2279 (e-PCR)
- UniSTS:473907

D22S1584 (e-PCR)
- UniSTS:473695

D1S1423 (e-PCR)
- UniSTS:149619

D16S325 (e-PCR)
- UniSTS:147089

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM7

Names: RING finger protein 90; glycogenin-interacting protein; tripartite motif protein TRIM7

NP_203128.1

EC 2.3.2.27

NP_976038.1

EC 2.3.2.27

NP_976039.1

EC 2.3.2.27

NP_976040.1

EC 2.3.2.27

NP_976041.1

EC 2.3.2.27

NP_976042.1

EC 2.3.2.27

XP_016865393.1

EC 2.3.2.27

XP_054209554.1

EC 2.3.2.27

XP_054209555.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029535.1 RefSeqGene

Range

4982..16254

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_033342.4 → NP_203128.1 E3 ubiquitin-protein ligase TRIM7 isoform 4

See identical proteins and their annotated locations for NP_203128.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 3' UTR and the 3' coding region, resulting in an early stop codon, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AF220032, BC080553

Consensus CDS

CCDS4464.1

UniProtKB/TrEMBL

B2RBZ0

Related

ENSP00000334666.5, ENST00000334421.5

Conserved Domains (3) summary

cd00021
Location:130 → 166

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cl17238
Location:29 → 81

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl21478
Location:159 → 211

ATP-synt_B; ATP synthase B/B' CF(0)
NM_203293.3 → NP_976038.1 E3 ubiquitin-protein ligase TRIM7 isoform 1

See identical proteins and their annotated locations for NP_976038.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as GNIP1) encodes the longest isoform (1).

Source sequence(s)

AF220032, BC132863, BM825056, BQ000256

Consensus CDS

CCDS4462.1

UniProtKB/Swiss-Prot

A2RUE4, D3DWR7, Q969F5, Q96F67, Q96J89, Q96J90, Q9C029

Related

ENSP00000274773.7, ENST00000274773.12

Conserved Domains (4) summary

cd00021
Location:130 → 166

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd13740
Location:343 → 511

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

pfam01442
Location:151 → 276

Apolipoprotein; Apolipoprotein A1/A4/E domain

cd16592
Location:26 → 82

RING-HC_TRIM7_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 7 (TRIM7) and similar proteins
NM_203294.2 → NP_976039.1 E3 ubiquitin-protein ligase TRIM7 isoform 3

See identical proteins and their annotated locations for NP_976039.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as GNIP2b) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AF396652, BM825056, BQ000256

Consensus CDS

CCDS4463.1

UniProtKB/Swiss-Prot

Q9C029

Conserved Domains (1) summary

cd13740
Location:135 → 303

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
NM_203295.2 → NP_976040.1 E3 ubiquitin-protein ligase TRIM7 isoform 3

See identical proteins and their annotated locations for NP_976040.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as GNIP2a) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AF396652, AF396653, BM825056, BQ000256

Consensus CDS

CCDS4463.1

UniProtKB/Swiss-Prot

Q9C029

Related

ENSP00000391458.2, ENST00000422067.2

Conserved Domains (1) summary

cd13740
Location:135 → 303

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
NM_203296.2 → NP_976041.1 E3 ubiquitin-protein ligase TRIM7 isoform 3

See identical proteins and their annotated locations for NP_976041.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as GNIP2c) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AC008443, AF396652, AF396654, BM825056, BQ000256

Consensus CDS

CCDS4463.1

UniProtKB/Swiss-Prot

Q9C029

Related

ENSP00000376991.1, ENST00000393315.5

Conserved Domains (1) summary

cd13740
Location:135 → 303

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
NM_203297.2 → NP_976042.1 E3 ubiquitin-protein ligase TRIM7 isoform 2

See identical proteins and their annotated locations for NP_976042.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as GNIP3) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC008443, AF396655, BM825056, BQ000256

Consensus CDS

CCDS43414.1

UniProtKB/Swiss-Prot

Q9C029

Related

ENSP00000376994.3, ENST00000393319.7

Conserved Domains (1) summary

cd13740
Location:161 → 329

SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

181193924..181205196 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017009904.3 → XP_016865393.1 E3 ubiquitin-protein ligase TRIM7 isoform X1

UniProtKB/TrEMBL

B2RBZ0

Conserved Domains (3) summary

cd00021
Location:130 → 166

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cl17238
Location:29 → 81

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl21478
Location:159 → 211

ATP-synt_B; ATP synthase B/B' CF(0)

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

181753960..181778284 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054353579.1 → XP_054209554.1 E3 ubiquitin-protein ligase TRIM7 isoform X2
XM_054353580.1 → XP_054209555.1 E3 ubiquitin-protein ligase TRIM7 isoform X1

UniProtKB/TrEMBL

B2RBZ0