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    TPBGL trophoblast glycoprotein like [ Homo sapiens (human) ]

    Gene ID: 100507050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TPBGLprovided by HGNC
    Official Full Name
    trophoblast glycoprotein likeprovided by HGNC
    Primary source
    HGNC:HGNC:44159
    See related
    Ensembl:ENSG00000261594 AllianceGenome:HGNC:44159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    mouse all
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    Genomic context

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    See TPBGL in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75240774..75243704)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75170381..75173311)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74951819..74954749)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902717 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74972903-74973402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:74973761-74974692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74976727-74977228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74977229-74977728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74983603-74984104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74988922-74989422 Neighboring gene arrestin beta 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74991005-74991880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75002568-75003068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75014529-75015343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75019873-75020374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75024683-75025599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75033894-75034520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75035773-75036398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75037071-75037602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75037603-75038135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5264 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75041995-75042528 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75042529-75043062 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75043063-75043596 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75044132-75044665 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75045734-75046268 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75046269-75046802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75051565-75052428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75052429-75053292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75057563-75058076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75058077-75058590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5266 Neighboring gene microRNA 326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75062958-75063913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75092225-75092873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5267 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75111125-75111988 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene ribosomal protein S3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trophoblast glycoprotein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195528.2 → NP_001182457.1  trophoblast glycoprotein-like precursor

      See identical proteins and their annotated locations for NP_001182457.1

      Status: VALIDATED

      Source sequence(s)
      AP001972, BC007804, N54218
      Consensus CDS
      CCDS60895.1
      UniProtKB/Swiss-Prot
      P0DKB5
      Related
      ENSP00000474988.1, ENST00000562197.3
      Conserved Domains (3) summary
      sd00031
      Location:61 → 95
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:94 → 151
      LRR_8; Leucine rich repeat
      cl15307
      Location:234 → 267
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      75240774..75243704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      75170381..75173311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DKB5.1 GenPept UniProtKB/Swiss-Prot:P0DKB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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