DNM3OS DNM3 opposite strand/antisense RNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: DNM3OSprovided by HGNC
Official Full Name: DNM3 opposite strand/antisense RNAprovided by HGNC
Primary source: HGNC:HGNC:41228
See related: AllianceGenome:HGNC:41228
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DNM3-AS1; MIR199A2HG
Summary: Enables miRNA inhibitor activity via base-pairing. Involved in cellular response to transforming growth factor beta stimulus and regulation of macromolecule metabolic process. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary (RPKM 8.5), endometrium (RPKM 7.1) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q24.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (172136879..172144835, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (171493599..171501554, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (172106019..172113975, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
Title: DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
[The potential role of long non-coding RNA Dnm3os in the activation of cardiac fibroblasts].
Title: [The potential role of long non-coding RNA Dnm3os in the activation of cardiac fibroblasts].
Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.
Title: Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.
DNM3OS Facilitates Ovarian Cancer Progression by Regulating miR-193a-3p/MAP3K3 Axis.
Title: DNM3OS Facilitates Ovarian Cancer Progression by Regulating miR-193a-3p/MAP3K3 Axis.
Long noncoding RNA DNM3OS promotes prostate stromal cells transformation via the miR-29a/29b/COL3A1 and miR-361/TGFbeta1 axes.
Title: Long noncoding RNA DNM3OS promotes prostate stromal cells transformation via the miR-29a/29b/COL3A1 and miR-361/TGFβ1 axes.
DNM3OS was found to have a much higher expression level in esophageal cancer cells and in tumor tissues of esophageal squamous cell carcinoma patient. FOXO1, a transcription factor downstream of PDGFbeta/PDGFRbeta signaling pathway, initiated the transcription of DNM3OS by binding to DNM3OS promoter. DNM3OS conferred significant radioresistance in vitro and in vivo by regulating DNA damage response.
Title: Cancer-associated Fibroblast-promoted LncRNA DNM3OS Confers Radioresistance by Regulating DNA Damage Response in Esophageal Squamous Cell Carcinoma.
DNM3OS knockdown inhibited the proliferation of Gastric Cancer cells, and reduced DNM3OS suppressed tumor growth in vivo.
Title: Long non-coding RNA DNM3OS promotes tumor progression and EMT in gastric cancer by associating with Snail.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Other Names

DNM3 antisense RNA 1 (non-protein coding)
DNM3 opposite strand/antisense RNA (non-protein coding)
MIR199A2 host gene (non-protein coding)
dynamin 3, opposite strand

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables miRNA inhibitor activity via base-pairing	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to transforming growth factor beta stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lncRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_038397.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AL137157, AU311708, FJ623959
NR_103486.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks three alternate segments, resulting in a shorter transcript, compared to variant 1.

Source sequence(s)

AL137157, AU311708, DB261523, FJ623959