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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_009818.1 RefSeqGene
- Range
-
5001..82045
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_483
mRNA and Protein(s)
-
NM_000457.6 → NP_000448.3 hepatocyte nuclear factor 4-alpha isoform 2
See identical proteins and their annotated locations for NP_000448.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) encodes the longest isoform (2, also known as HNF4alpha2).
- Source sequence(s)
-
AL132772
- Consensus CDS
-
CCDS13330.1
- UniProtKB/Swiss-Prot
- A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T1
- Related
- ENSP00000312987.3, ENST00000316099.10
- Conserved Domains (2) summary
-
- cd06931
Location:151 → 373
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:60 → 135
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_001030003.3 → NP_001025174.1 hepatocyte nuclear factor 4-alpha isoform 4
See identical proteins and their annotated locations for NP_001025174.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) contains an alternate 5' terminal exon (resulting in translation initiation from an alternate upstream start codon) and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 2. The resulting shorter isoform (4, also known as HNF4alpha7) has a distinct N-terminus and lacks a 10 aa protein segment in the C-terminal region compared to isoform 2.
- Source sequence(s)
-
AL117382, AL132772, AW134564, AY680696
- Consensus CDS
-
CCDS46604.1
- UniProtKB/TrEMBL
-
B6ZGT3
- Related
- ENSP00000396216.1, ENST00000457232.5
- Conserved Domains (2) summary
-
- cd06931
Location:129 → 351
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:38 → 113
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_001030004.3 → NP_001025175.1 hepatocyte nuclear factor 4-alpha isoform 6
See identical proteins and their annotated locations for NP_001025175.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) contains an alternate 5' terminal exon (resulting in translation initiation from an alternate upstream start codon) and differs at the 3' end that causes a frame-shift compared to variant 2. The resulting shorter isoform (6, also known as HNF4alpha9) has distinct N- and C-termini compared to isoform 2.
- Source sequence(s)
-
AL117382, AL132772, AY680698
- Consensus CDS
-
CCDS68131.1
- UniProtKB/TrEMBL
-
A0A087WXV4
- Related
- ENSP00000476609.1, ENST00000609795.5
- Conserved Domains (2) summary
-
- cd06931
Location:129 → 351
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:38 → 113
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_001258355.2 → NP_001245284.1 hepatocyte nuclear factor 4-alpha isoform 7
See identical proteins and their annotated locations for NP_001245284.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) contains an additional coding exon in the 5' region that results in translation initiation from an alternate downstream start codon compared to variant 2. The resulting shorter isoform (7) has a distinct N-terminus compared to isoform 2.
- Source sequence(s)
-
AL132772, AW134564, BP274413, HQ692869, Z49825
- UniProtKB/TrEMBL
-
B6ZGT3
- Conserved Domains (2) summary
-
- cd06931
Location:144 → 366
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:53 → 128
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_001287182.2 → NP_001274111.1 hepatocyte nuclear factor 4-alpha isoform 8
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) differs at the 5' end (resulting in translation initiation from an alternate upstream start codon) and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 2. The resulting shorter isoform (8, also known as HNF4alpha10) has a distinct N-terminus and lacks a 10 aa protein segment in the C-terminal region compared to isoform 2.
- Source sequence(s)
-
AL117382, AL132772, AW134564, AY680696, FJ608822
- UniProtKB/TrEMBL
-
B6ZGT3
- Conserved Domains (2) summary
-
- cd06931
Location:126 → 348
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:35 → 110
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_001287183.2 → NP_001274112.1 hepatocyte nuclear factor 4-alpha isoform 9
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) differs at the 5' end, which results in translation initiation from an alternate upstream start codon compared to variant 2. The resulting shorter isoform (9, also known as HNF4alpha11) has a distinct N-terminus compared to isoform 2.
- Source sequence(s)
-
AL117382, AL132772
- UniProtKB/TrEMBL
-
B6ZGT3
- Conserved Domains (2) summary
-
- cd06931
Location:126 → 348
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:35 → 110
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_001287184.2 → NP_001274113.1 hepatocyte nuclear factor 4-alpha isoform 10
Status: REVIEWED
- Description
- Transcript Variant: This variant (10) differs at the 5' end (resulting in translation initiation from an alternate upstream start codon) and at the 3' end (that causes a frame-shift) compared to variant 2. The resulting shorter isoform (10, also known as HNF4alpha12) has distinct N- and C-termini compared to isoform 2.
- Source sequence(s)
-
AL117382, AL132772, AY680698, BC137539, FJ608822
- UniProtKB/TrEMBL
-
A0A087WXV4
- Conserved Domains (2) summary
-
- cd06931
Location:126 → 348
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:35 → 110
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_175914.5 → NP_787110.2 hepatocyte nuclear factor 4-alpha isoform 5
See identical proteins and their annotated locations for NP_787110.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) contains an alternate 5' terminal exon, which results in translation initiation from an alternate upstream start codon compared to variant 2. The resulting shorter isoform (5, also known as HNF4alpha8) has a distinct N-terminus compared to isoform 2.
- Source sequence(s)
-
AL117382, AL132772
- Consensus CDS
-
CCDS42876.1
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T0
- Related
- ENSP00000315180.4, ENST00000316673.9
- Conserved Domains (2) summary
-
- cd06931
Location:129 → 351
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:38 → 113
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_178849.3 → NP_849180.1 hepatocyte nuclear factor 4-alpha isoform 1
See identical proteins and their annotated locations for NP_849180.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) uses an alternate in-frame donor splice site in the 3' coding region compared to variant 2. The resulting shorter isoform (1, also known as HNF4alpha1) lacks a 10 aa protein segment compared to isoform 2.
- Source sequence(s)
-
AL132772, AW134564, BP274413, HQ692860
- Consensus CDS
-
CCDS46605.1
- UniProtKB/TrEMBL
- B6ZGT3, F1D8S2
- Related
- ENSP00000412111.1, ENST00000415691.2
- Conserved Domains (2) summary
-
- cd06931
Location:151 → 373
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:60 → 135
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
-
NM_178850.3 → NP_849181.1 hepatocyte nuclear factor 4-alpha isoform 3
See identical proteins and their annotated locations for NP_849181.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) has a different 3' end that causes a frame-shift compared to variant 2. The resulting shorter isoform (3, also known as HNF4alpha3) has a distinct C-terminus compared to isoform 2.
- Source sequence(s)
-
AL132772, BC137539, BP274413
- Consensus CDS
-
CCDS13331.1
- UniProtKB/TrEMBL
-
A0A087WXV4
- Related
- ENSP00000410911.2, ENST00000443598.6
- Conserved Domains (2) summary
-
- cd06931
Location:151 → 373
- NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
- cd06960
Location:60 → 135
- NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000020.11 Reference GRCh38.p14 Primary Assembly
- Range
-
44355699..44434596
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047440138.1 → XP_047296094.1 hepatocyte nuclear factor 4-alpha isoform X2
- UniProtKB/TrEMBL
- B6ZGT3, F1D8S2
-
XM_047440135.1 → XP_047296091.1 hepatocyte nuclear factor 4-alpha isoform X1
- UniProtKB/Swiss-Prot
- A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T1
-
XM_047440136.1 → XP_047296092.1 hepatocyte nuclear factor 4-alpha isoform X1
- UniProtKB/Swiss-Prot
- A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T1
-
XM_047440137.1 → XP_047296093.1 hepatocyte nuclear factor 4-alpha isoform X1
- UniProtKB/Swiss-Prot
- A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T1
Alternate T2T-CHM13v2.0
Genomic
-
NC_060944.1 Alternate T2T-CHM13v2.0
- Range
-
46090439..46170188
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054323403.1 → XP_054179378.1 hepatocyte nuclear factor 4-alpha isoform X1
- UniProtKB/Swiss-Prot
- A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T1
-
XM_054323402.1 → XP_054179377.1 hepatocyte nuclear factor 4-alpha isoform X1
- UniProtKB/Swiss-Prot
- A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T1
-
XM_054323405.1 → XP_054179380.1 hepatocyte nuclear factor 4-alpha isoform X2
- UniProtKB/TrEMBL
- B6ZGT3, F1D8S2
-
XM_054323404.1 → XP_054179379.1 hepatocyte nuclear factor 4-alpha isoform X1
- UniProtKB/Swiss-Prot
- A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
- UniProtKB/TrEMBL
- B6ZGT3, F1D8T1