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    MRFAP1L1 Morf4 family associated protein 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 114932, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MRFAP1L1provided by HGNC
    Official Full Name
    Morf4 family associated protein 1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:28796
    See related
    Ensembl:ENSG00000178988 AllianceGenome:HGNC:28796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP784
    Summary
    Enables identical protein binding activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 49.2), endometrium (RPKM 34.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See MRFAP1L1 in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (6707701..6709865, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (6682758..6684921, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6709428..6711592, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:6690316-6691515 Neighboring gene long intergenic non-protein coding RNA 2481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6694289-6694826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695136-6695872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695873-6696608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6697811-6698573 Neighboring gene S100 calcium binding protein P Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:6710044-6711243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21261 Neighboring gene uncharacterized LOC105378240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:6718303-6718942 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. Bowman BR, et al. Structure, 2006 Jan. PMID 16407074
    2. Development and application of a DNA microarray-based yeast two-hybrid system. Suter B, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275563, Free PMC Article
    3. rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Yang JS, et al. Nat Commun, 2018 Sep 14. PMID 30217970, Free PMC Article
    4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
    5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9651

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MORF4 family-associated protein 1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203462.3 → NP_982287.1  MORF4 family-associated protein 1-like 1

      See identical proteins and their annotated locations for NP_982287.1

      Status: VALIDATED

      Source sequence(s)
      AC093323, BC008087, BC066897
      Consensus CDS
      CCDS3392.1
      UniProtKB/Swiss-Prot
      B2R6R0, Q6NXT8, Q96HT8, Q9P0J5
      UniProtKB/TrEMBL
      A0A075DDR2
      Related
      ENSP00000318154.6, ENST00000320848.7
      Conserved Domains (1) summary
      pfam15155
      Location:1 → 127
      MRFAP1; MORF4 family-associated protein1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      6707701..6709865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      6682758..6684921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152301.3: Suppressed sequence

      Description
      NM_152301.3: This RefSeq was permanently suppressed because it contains intronic sequence and currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96HT8.1 GenPept UniProtKB/Swiss-Prot:Q96HT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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