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    SLC10A1 solute carrier family 10 member 1 [ Homo sapiens (human) ]

    Gene ID: 6554, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLC10A1provided by HGNC
    Official Full Name
    solute carrier family 10 member 1provided by HGNC
    Primary source
    HGNC:HGNC:10905
    See related
    Ensembl:ENSG00000100652 MIM:182396; AllianceGenome:HGNC:10905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTCP; FHCA2
    Summary
    The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
    Expression
    Restricted expression toward liver (RPKM 124.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC10A1 in Genome Data Viewer
    Location:
    14q24.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (69775416..69797241, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (63983088..64004909, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70242133..70263958, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70088656-70089156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8641 Neighboring gene sushi domain containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70104475-70104987 Neighboring gene Sharpr-MPRA regulatory region 10837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70124416-70125196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8645 Neighboring gene Sharpr-MPRA regulatory region 2331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8646 Neighboring gene Sharpr-MPRA regulatory region 930 Neighboring gene Sharpr-MPRA regulatory region 8327 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:70207027-70208226 Neighboring gene uncharacterized LOC100289511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70233975-70234739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8649 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:70237232-70238431 Neighboring gene serine and arginine rich splicing factor 5 Neighboring gene Sharpr-MPRA regulatory region 10266 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene uncharacterized LOC100506358

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (SLC10A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables bile acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bile acid:sodium symporter activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bile acid and bile salt transport TAS
    Traceable Author Statement
    more info
     
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    hepatic sodium/bile acid cotransporter
    Names
    Na(+)/bile acid cotransporter
    Na(+)/taurocholate transport protein
    Na/taurocholate cotransporting polypeptide
    cell growth-inhibiting gene 29 protein
    growth-inhibiting protein 29
    sodium/bile acid cotransporter
    sodium/taurocholate cotransporter
    sodium/taurocholate cotransporting polypeptide
    solute carrier family 10 (sodium/bile acid cotransporter family), member 1
    solute carrier family 10 (sodium/bile acid cotransporter), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003049.4NP_003040.1  hepatic sodium/bile acid cotransporter

      See identical proteins and their annotated locations for NP_003040.1

      Status: REVIEWED

      Source sequence(s)
      AK314028, AL157789, BC069799, L21893
      Consensus CDS
      CCDS9797.1
      UniProtKB/Swiss-Prot
      B9EGB6, Q14973, Q2TU29
      UniProtKB/TrEMBL
      B2RA41
      Related
      ENSP00000216540.4, ENST00000216540.5
      Conserved Domains (1) summary
      TIGR00841
      Location:22311
      bass; bile acid transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      69775416..69797241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      63983088..64004909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)