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    BORCS6 BLOC-1 related complex subunit 6 [ Homo sapiens (human) ]

    Gene ID: 54785, updated on 4-Jan-2025

    Summary

    Official Symbol
    BORCS6provided by HGNC
    Official Full Name
    BLOC-1 related complex subunit 6provided by HGNC
    Primary source
    HGNC:HGNC:25939
    See related
    Ensembl:ENSG00000196544 MIM:616599; AllianceGenome:HGNC:25939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO2472; C17orf59
    Summary
    Enables identical protein binding activity. Involved in lysosome localization. Part of BORC complex. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See BORCS6 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8188345..8190180, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8094509..8096344, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8091663..8093498, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8172 Neighboring gene tRNA-Thr (anticodon AGT) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11680 Neighboring gene tRNA-Ile (anticodon AAT) 5-5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8092665-8093311 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8093312-8093957 Neighboring gene uncharacterized LOC124903913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11683 Neighboring gene nonconserved acetylation island sequence 72 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8107017-8107517 Neighboring gene aurora kinase B Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8113125-8113784

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Clone Names

    • FLJ20014

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of BORC complex  
    part_of BORC complex PubMed 
    part_of BORC complex PubMed 
    located_in cytoplasmic side of lysosomal membrane PubMed 

    General protein information

    Preferred Names
    BLOC-1-related complex subunit 6
    Names
    lysosome-dispersing protein
    lyspersin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017622.3 → NP_060092.2  BLOC-1-related complex subunit 6

      See identical proteins and their annotated locations for NP_060092.2

      Status: VALIDATED

      Source sequence(s)
      AI174760, CA423621, DA199264, DR006664
      Consensus CDS
      CCDS11133.2
      UniProtKB/Swiss-Prot
      Q53HS4, Q96GS4, Q9NXW8
      Related
      ENSP00000373669.4, ENST00000389017.6
      Conserved Domains (1) summary
      pfam10157
      Location:210 → 355
      DUF2365; Uncharacterized conserved protein (DUF2365)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8188345..8190180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8094509..8096344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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