CPEB4 cytoplasmic polyadenylation element binding protein 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CPEB4provided by HGNC
Official Full Name: cytoplasmic polyadenylation element binding protein 4provided by HGNC
Primary source: HGNC:HGNC:21747
See related: Ensembl:ENSG00000113742 MIM:610607; AllianceGenome:HGNC:21747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CPE-BP4; hCPEB-4
Summary: Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Located in cytoplasm and nucleus. Biomarker of liver cirrhosis; portal hypertension; and primary biliary cholangitis. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal (RPKM 26.5), bone marrow (RPKM 18.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (173888349..173961980)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (174428718..174502324)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (173315352..173388983)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-Regulation of CPEB4 Alleviates Preeclampsia through the Inhibition of Ferroptosis by PFKFB3.
Title: Down-Regulation of CPEB4 Alleviates Preeclampsia through the Inhibition of Ferroptosis by PFKFB3.
Antitumor T-cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress.
Title: Antitumor T-cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress.
Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation.
Title: Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation.
Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis.
Title: Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis.
Investigation of the expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different stage colorectal tumors
Title: Investigation of the expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different stage colorectal tumors.
CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
Title: CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
Title: LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
Title: Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
LncRNA RP11-361F15.2 promotes osteosarcoma tumorigenesis by inhibiting M2-Like polarization of tumor-associated macrophages of CPEB4.
Title: LncRNA RP11-361F15.2 promotes osteosarcoma tumorigenesis by inhibiting M2-Like polarization of tumor-associated macrophages of CPEB4.
Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis.
Title: Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93220 (e-PCR)
- UniSTS:90121

STS-H95340 (e-PCR)
- UniSTS:37908

G16920 (e-PCR)
- UniSTS:82971

STS-H71226 (e-PCR)
- UniSTS:52252

SHGC-111286 (e-PCR)
- UniSTS:168280

Cpeb4 (e-PCR), detects polymorphism
- UniSTS:479085

WI-14103 (e-PCR)
- UniSTS:80520

RH45640 (e-PCR)
- UniSTS:65427

bac51093T (e-PCR)
- UniSTS:181427

G16921 (e-PCR)
- UniSTS:57012

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to decreased oxygen levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ischemia	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 4

Names: CPE-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308189.2 → NP_001295118.1 cytoplasmic polyadenylation element-binding protein 4 isoform b

See identical proteins and their annotated locations for NP_001295118.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AB051460, AC093275, AI742270, BC143958, BQ061431, BU629646, BX538213, CR741268, DA803281, R64139

Consensus CDS

CCDS78086.1

UniProtKB/TrEMBL

E5RJM0

Related

ENSP00000334533.5, ENST00000334035.9

Conserved Domains (3) summary

pfam16366
Location:638 → 699

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:455 → 546

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:563 → 643

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
NM_001308191.2 → NP_001295120.1 cytoplasmic polyadenylation element-binding protein 4 isoform c

See identical proteins and their annotated locations for NP_001295120.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.

Source sequence(s)

AB051460, AC093275, AI742270, BC143959, BQ061431, BU629646, BX538213, CR741268, DA803281, R64139

Consensus CDS

CCDS78087.1

UniProtKB/TrEMBL

B7ZLQ8, E5RJM0

Related

ENSP00000429092.1, ENST00000520867.5

Conserved Domains (3) summary

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
NM_001308192.2 → NP_001295121.1 cytoplasmic polyadenylation element-binding protein 4 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, and it also lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus and lacks an internal segment, compared to isoform a.

Source sequence(s)

AB051460, AC093275, AI742270, BC036899, BX401008, BX538213, CR741268, R64139

Consensus CDS

CCDS83043.1

UniProtKB/TrEMBL

A0A590UJI5, E5RFP2

Related

ENSP00000430345.1, ENST00000522336.5

Conserved Domains (3) summary

pfam16366
Location:265 → 326

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:82 → 173

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:190 → 270

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
NM_001308193.2 → NP_001295122.1 cytoplasmic polyadenylation element-binding protein 4 isoform e

See identical proteins and their annotated locations for NP_001295122.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate 5' terminal exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, and it also lacks two alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus and lacks an internal segment, compared to isoform a.

Source sequence(s)

AB051460, AC093275, AI742270, BC036899, BX401008, BX538213, CR741268, R64139

Consensus CDS

CCDS83044.1

UniProtKB/TrEMBL

A0A590UJI5

Related

ENSP00000427990.1, ENST00000517880.1

Conserved Domains (3) summary

cd12724
Location:65 → 156

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:173 → 253

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:248 → 309

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_030627.4 → NP_085130.2 cytoplasmic polyadenylation element-binding protein 4 isoform a

See identical proteins and their annotated locations for NP_085130.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AB051460, AC093275, AI742270, BC117150, BQ061431, BU629646, BX538213, CR741268, DA803281, R64139

Consensus CDS

CCDS4390.1

UniProtKB/Swiss-Prot

B7ZLQ7, Q17RY0, Q7Z310, Q8N405, Q9C0J0

UniProtKB/TrEMBL

E5RJM0

Related

ENSP00000265085.5, ENST00000265085.10

Conserved Domains (3) summary

pfam16366
Location:655 → 716

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:472 → 563

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:580 → 660

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens