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    HOTAIR HOX transcript antisense RNA [ Homo sapiens (human) ]

    Gene ID: 100124700, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HOTAIRprovided by HGNC
    Official Full Name
    HOX transcript antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:33510
    See related
    Ensembl:ENSG00000228630 MIM:611400; AllianceGenome:HGNC:33510
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072
    Summary
    This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]
    Expression
    Biased expression in testis (RPKM 1.6), skin (RPKM 1.2) and 6 other tissues See more
    Orthologs
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    Genomic context

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    See HOTAIR in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53962312..53974954, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53927801..53940446, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54356096..54368738, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HOXC13 antisense RNA Neighboring gene homeobox C13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54345326-54345913 Neighboring gene uncharacterized LOC105369775 Neighboring gene homeobox C12 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:54355207-54355431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54360165-54361069 Neighboring gene NUP98-HOXC11 recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54368136-54368730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6430 Neighboring gene homeobox C11 Neighboring gene HOXC11-HOXC10 intergenic CAGE-defined high expression enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54379714-54380594 Neighboring gene HOXC cluster antisense RNA 3 Neighboring gene homeobox C10 Neighboring gene microRNA 196a-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA HOTAIR promotes tumorigenesis and forecasts a poor prognosis in cholangiocarcinoma. Qin W, et al. Sci Rep, 2018 Aug 15. PMID 30111807, Free PMC Article
    2. Long non-coding RNA HOTAIR promotes osteoarthritis progression via miR-17-5p/FUT2/β-catenin axis. Hu J, et al. Cell Death Dis, 2018 Jun 15. PMID 29907764, Free PMC Article
    3. Rs4759314 polymorphism located in HOTAIR is associated with the risk of congenital heart disease by alternating downstream signaling via reducing its expression. Li Y, et al. J Cell Biochem, 2018 Nov. PMID 29932240
    4. The prognostic value of HOTAIR for predicting long-term prognosis of patients with gastrointestinal cancers. Zhang Y, et al. Medicine (Baltimore), 2018 Jun. PMID 29952959, Free PMC Article
    5. Effect of HOTAIR rs12826786 and rs1899663 polymorphisms on lung cancer susceptibility and clinicopathological characteristics in a turkish population: a hospital-based case-control study. Dadaş E, et al. Cell Mol Biol (Noisy-le-grand), 2018 May 30. PMID 29974853

    See all (505) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HOTAIR Promotes the Hyperactivation of PI3K/Akt and Wnt/beta-Catenin Signaling Pathways via PTEN Hypermethylation in Cervical Cancer.
      Title: HOTAIR Promotes the Hyperactivation of PI3K/Akt and Wnt/β-Catenin Signaling Pathways via PTEN Hypermethylation in Cervical Cancer.
    2. LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
      Title: LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
    3. A Study on Associations of Long Noncoding RNA HOTAIR Polymorphisms With Genetic Susceptibility to Chronic Kidney Disease.
      Title: A Study on Associations of Long Noncoding RNA HOTAIR Polymorphisms With Genetic Susceptibility to Chronic Kidney Disease.
    4. Long non-coding RNA HOTAIR: from pan-cancer analysis to colorectal cancer-related uridine metabolism.
      Title: Long non-coding RNA HOTAIR: from pan-cancer analysis to colorectal cancer-related uridine metabolism.
    5. The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women.
      Title: The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women.
    6. Adolescent polycystic ovary syndrome without obesity: HOTAIR rs1443512 genotype relates to fat mass and to the redistribution of fat mass on low-dose pioglitazone.
      Title: Adolescent polycystic ovary syndrome without obesity: HOTAIR rs1443512 genotype relates to fat mass and to the redistribution of fat mass on low-dose pioglitazone.
    7. Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders.
      Title: Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders.
    8. Potential role of the lncRNA "HOTAIR"/miRNA "206"/BDNF network in the alteration in expression of synaptic plasticity gene arc and BDNF level in sera of patients with heroin use disorder through the PI3K/AKT/mTOR pathway compared to the controls.
      Title: Potential role of the lncRNA "HOTAIR"/miRNA "206"/BDNF network in the alteration in expression of synaptic plasticity gene arc and BDNF level in sera of patients with heroin use disorder through the PI3K/AKT/mTOR pathway compared to the controls.
    9. LncRNA HOTAIR Inhibits miR-19a-3p to Alleviate Foam Cell Formation and Inflammatory Response in Atherosclerosis.
      Title: LncRNA HOTAIR Inhibits miR-19a-3p to Alleviate Foam Cell Formation and Inflammatory Response in Atherosclerosis.
    10. HOTAIR: A key regulator of the Wnt/beta-catenin signaling cascade in cancer progression and treatment.
      Title: HOTAIR: A key regulator of the Wnt/β-catenin signaling cascade in cancer progression and treatment.
    Submit: New GeneRIF Correction See all GeneRIFs (481)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Other Names

    • HOX transcript antisense RNA (non-protein coding)
    • HOXC cluster antisense RNA 4 (non-protein coding)
    • hox transcript antisense intergenic RNA

    Clone Names

    • FLJ41747

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003716.4 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531
      Related
      ENST00000717836.1

    2. NR_047517.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    3. NR_047518.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    4. NR_186237.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    5. NR_186238.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    6. NR_186239.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    7. NR_186240.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    8. NR_186241.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531
      Related
      ENST00000424518.6

    9. NR_186242.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    10. NR_186243.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    11. NR_186244.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    12. NR_186245.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    13. NR_186246.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    14. NR_186247.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    15. NR_186248.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531

    16. NR_186249.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531
      Related
      ENST00000717832.1

    17. NR_186250.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012531
      Related
      ENST00000717834.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53962312..53974954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      53927801..53940446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials