U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    KIF9 kinesin family member 9 [ Homo sapiens (human) ]

    Gene ID: 64147, updated on 10-Dec-2024

    Summary

    Official Symbol
    KIF9provided by HGNC
    Official Full Name
    kinesin family member 9provided by HGNC
    Primary source
    HGNC:HGNC:16666
    See related
    Ensembl:ENSG00000088727 MIM:607910; AllianceGenome:HGNC:16666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables identical protein binding activity. Involved in extracellular matrix disassembly; organelle disassembly; and regulation of podosome assembly. Located in microtubule; podosome; and vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 11.7), thyroid (RPKM 1.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF9 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (47227998..47282799, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (47244385..47299181, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47269488..47324289, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:47082829-47083038 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 3 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47108907-47109512 Neighboring gene NANOG hESC enhancer GRCh37_chr3:47125242-47125743 Neighboring gene uncharacterized LOC124906375 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155200-47155707 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155708-47156216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19809 Neighboring gene KIF9 antisense RNA 1 Neighboring gene MPRA-validated peak4632 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47238926-47239426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19810 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:47301362-47302268 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 13J Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:47323613-47324812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14308 Neighboring gene kelch like family member 18 Neighboring gene Sharpr-MPRA regulatory region 13740 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:47403837-47405036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47421897-47422574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:47422575-47423250 Neighboring gene PTPN23 divergent transcript Neighboring gene protein tyrosine phosphatase non-receptor type 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC104186

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables identical protein binding PubMed 
    enables microtubule binding  
    enables microtubule motor activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    part_of kinesin complex  
    is_active_in microtubule  
    located_in microtubule PubMed 
    located_in podosome PubMed 
    located_in sperm flagellum  
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF9
    Names
    kinesin protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134878.3 → NP_001128350.1  kinesin-like protein KIF9 isoform 2

      See identical proteins and their annotated locations for NP_001128350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and includes an alternate in-frame exon in the mid coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC104447, AI741745, AK292547, AK314418
      Consensus CDS
      CCDS2752.1
      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000391100.2, ENST00000452770.6
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain
    2. NM_001377474.1 → NP_001364403.1  kinesin-like protein KIF9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (1) summary
      cl22853
      Location:6 → 263
      Motor_domain; Myosin and Kinesin motor domain
    3. NM_001377475.1 → NP_001364404.1  kinesin-like protein KIF9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (1) summary
      cl22853
      Location:6 → 263
      Motor_domain; Myosin and Kinesin motor domain
    4. NM_001377476.1 → NP_001364405.1  kinesin-like protein KIF9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104447
      Consensus CDS
      CCDS93262.1
      UniProtKB/TrEMBL
      E7EUW8, Q6PJI1
      Related
      ENSP00000391099.1, ENST00000432493.5
      Conserved Domains (1) summary
      cl22853
      Location:6 → 89
      Motor_domain; Myosin and Kinesin motor domain
    5. NM_001377477.1 → NP_001364406.1  kinesin-like protein KIF9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104447
      Consensus CDS
      CCDS93262.1
      UniProtKB/TrEMBL
      E7EUW8, Q6PJI1
      Related
      ENSP00000406815.1, ENST00000425853.5
      Conserved Domains (1) summary
      cl22853
      Location:6 → 89
      Motor_domain; Myosin and Kinesin motor domain
    6. NM_001413975.1 → NP_001400904.1  kinesin-like protein KIF9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
    7. NM_001413976.1 → NP_001400905.1  kinesin-like protein KIF9 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
    8. NM_022342.6 → NP_071737.1  kinesin-like protein KIF9 isoform 1

      See identical proteins and their annotated locations for NP_071737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AC104447, AF311212, AI741745, AK292547
      Consensus CDS
      CCDS2751.1
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000414987.2, ENST00000444589.6
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain
    9. NM_182902.4 → NP_878905.2  kinesin-like protein KIF9 isoform 2

      See identical proteins and their annotated locations for NP_878905.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the mid coding region, compared to variant 1, and encodes an isoform (2) that is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC104447, AI741745, AK292547, AK314418, BC030657
      Consensus CDS
      CCDS2752.1
      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000507186.1, ENST00000684063.1
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      47227998..47282799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448712.1 → XP_047304668.1  kinesin-like protein KIF9 isoform X6

      UniProtKB/TrEMBL
      A8K932
    2. XM_006713291.4 → XP_006713354.1  kinesin-like protein KIF9 isoform X4

      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cl22853
      Location:39 → 296
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:45 → 298
      Kinesin; Kinesin motor domain
    3. XM_005265389.5 → XP_005265446.1  kinesin-like protein KIF9 isoform X2

      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cd01375
      Location:39 → 371
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:45 → 373
      Kinesin; Kinesin motor domain
    4. XM_047448709.1 → XP_047304665.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
    5. XM_017007029.2 → XP_016862518.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain
    6. XM_047448711.1 → XP_047304667.1  kinesin-like protein KIF9 isoform X5

      UniProtKB/TrEMBL
      A8K932
    7. XM_011534007.3 → XP_011532309.1  kinesin-like protein KIF9 isoform X8

    8. XM_047448710.1 → XP_047304666.1  kinesin-like protein KIF9 isoform X3

      UniProtKB/TrEMBL
      A8K932
    9. XM_047448713.1 → XP_047304669.1  kinesin-like protein KIF9 isoform X7

      UniProtKB/TrEMBL
      B4DXP8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      47244385..47299181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347531.1 → XP_054203506.1  kinesin-like protein KIF9 isoform X6

      UniProtKB/TrEMBL
      A8K932
    2. XM_054347529.1 → XP_054203504.1  kinesin-like protein KIF9 isoform X4

      UniProtKB/TrEMBL
      A8K932
    3. XM_054347527.1 → XP_054203502.1  kinesin-like protein KIF9 isoform X2

      UniProtKB/TrEMBL
      A8K932
    4. XM_054347525.1 → XP_054203500.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/TrEMBL
      A8K932
    5. XM_054347526.1 → XP_054203501.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/TrEMBL
      A8K932
    6. XM_054347530.1 → XP_054203505.1  kinesin-like protein KIF9 isoform X5

      UniProtKB/TrEMBL
      A8K932
    7. XM_054347533.1 → XP_054203508.1  kinesin-like protein KIF9 isoform X8

    8. XM_054347528.1 → XP_054203503.1  kinesin-like protein KIF9 isoform X3

      UniProtKB/TrEMBL
      A8K932
    9. XM_054347532.1 → XP_054203507.1  kinesin-like protein KIF9 isoform X7

      UniProtKB/TrEMBL
      B4DXP8

    External link. Please review our privacy policy.