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    ZFP36L1 ZFP36 ring finger protein like 1 [ Homo sapiens (human) ]

    Gene ID: 677, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZFP36L1provided by HGNC
    Official Full Name
    ZFP36 ring finger protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:1107
    See related
    Ensembl:ENSG00000185650 MIM:601064; AllianceGenome:HGNC:1107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B
    Summary
    This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in endometrium (RPKM 164.2), ovary (RPKM 123.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZFP36L1 in Genome Data Viewer
    Location:
    14q24.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (68787655..68796243, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (62994521..63003244, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69254372..69262960, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69203012-69203538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69203539-69204063 Neighboring gene RNA, U6 small nuclear 921, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69229160-69229660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69229661-69230161 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36402 Neighboring gene uncharacterized LOC107984709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69247495-69247996 Neighboring gene HNF1 motif-containing MPRA enhancer 48 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5870 Neighboring gene Sharpr-MPRA regulatory region 7662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69256702-69257317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5872 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69261405-69261949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69283011-69283750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8629 Neighboring gene Sharpr-MPRA regulatory region 4438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69310317-69310829 Neighboring gene mago homolog 3, pseudogene Neighboring gene basic leucine zipper nuclear factor 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (148 hits/1299 screens)

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding PubMed 
    enables DNA binding  
    enables RNA binding PubMed 
    enables mRNA 3'-UTR AU-rich region binding PubMed 
    enables mRNA binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    Items 1 - 25 of 50
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization PubMed 
    involved_in 3'-UTR-mediated mRNA destabilization PubMed 
    involved_in ERK1 and ERK2 cascade PubMed 
    involved_in MAPK cascade PubMed 
    involved_in T cell differentiation in thymus  
    involved_in apoptotic process  
    involved_in cell population proliferation  
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to fibroblast growth factor stimulus  
    involved_in cellular response to glucocorticoid stimulus PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to peptide hormone stimulus PubMed 
    involved_in cellular response to raffinose  
    involved_in cellular response to salt stress  
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in chorio-allantoic fusion  
    involved_in heart development  
    involved_in mRNA processing  
    involved_in mRNA transport PubMed 
    involved_in mesendoderm development  
    involved_in multicellular organism growth  
    involved_in negative regulation of erythrocyte differentiation PubMed 
    involved_in negative regulation of mitotic cell cycle phase transition  
    involved_in neural tube development  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  
    involved_in p38MAPK cascade  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of fat cell differentiation  
    involved_in positive regulation of intracellular mRNA localization PubMed 
    involved_in positive regulation of monocyte differentiation PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in proepicardium development  
    involved_in regulation of B cell differentiation  
    involved_in regulation of gene expression PubMed 
    involved_in regulation of keratinocyte apoptotic process PubMed 
    involved_in regulation of keratinocyte differentiation PubMed 
    involved_in regulation of keratinocyte proliferation PubMed 
    involved_in regulation of mRNA 3'-end processing PubMed 
    acts_upstream_of_or_within regulation of mRNA stability PubMed 
    involved_in regulation of mRNA stability PubMed 
    involved_in regulation of mRNA stability PubMed 
    involved_in regulation of myoblast differentiation  
    involved_in regulation of stem cell proliferation  
    involved_in regulation of translation  
    involved_in response to wounding PubMed 
    involved_in vasculogenesis  
    Items 1 - 25 of 50
    Component Evidence Code Pubs
    located_in P-body PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in nucleus PubMed 
    part_of ribonucleoprotein complex PubMed 

    General protein information

    Preferred Names
    mRNA decay activator protein ZFP36L1
    Names
    EGF-response factor 1
    TPA-induced sequence 11b
    ZFP36-like 1
    butyrate response factor 1
    early response factor Berg36
    zinc finger protein 36, C3H type-like 1
    zinc finger protein 36, C3H1 type-like 1
    zinc finger protein, C3H type, 36-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244698.2 → NP_001231627.1  mRNA decay activator protein ZFP36L1 isoform 1

      See identical proteins and their annotated locations for NP_001231627.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end, and has a shorter 3' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK024202, BC018340, BQ004874, BQ894292, DA876968, DR423896
      Consensus CDS
      CCDS9791.1
      UniProtKB/Swiss-Prot
      Q07352, Q13851
      UniProtKB/TrEMBL
      B3KNA8
      Related
      ENSP00000337386.3, ENST00000336440.4
      Conserved Domains (2) summary
      COG5063
      Location:115 → 177
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam04553
      Location:1 → 105
      Tis11B_N; Tis11B like protein, N-terminus
    2. NM_001244701.1 → NP_001231630.1  mRNA decay activator protein ZFP36L1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional exon at the 5' end compared to variant 1, that introduces an in-frame upstream AUG, translation from which results in an isoform (2) with a longer N-terminus compared to isoform 1.
      Source sequence(s)
      BC018340, BM712842, BP353132, BQ004874, BQ894292, DA633985, DR423896, FY210721
      UniProtKB/TrEMBL
      B3KNA8
      Conserved Domains (2) summary
      pfam00642
      Location:184 → 209
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04553
      Location:72 → 168
      Tis11B_N; Tis11B like protein, N terminus
    3. NM_004926.4 → NP_004917.2  mRNA decay activator protein ZFP36L1 isoform 1

      See identical proteins and their annotated locations for NP_004917.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI493871, AK024202, BC018340, BM712842, BQ894292, CN312799, DB522201, DR423896
      Consensus CDS
      CCDS9791.1
      UniProtKB/Swiss-Prot
      Q07352, Q13851
      UniProtKB/TrEMBL
      B3KNA8
      Related
      ENSP00000388402.2, ENST00000439696.3
      Conserved Domains (2) summary
      COG5063
      Location:115 → 177
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam04553
      Location:1 → 105
      Tis11B_N; Tis11B like protein, N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      68787655..68796243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      62994521..63003244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376649.1 → XP_054232624.1  mRNA decay activator protein ZFP36L1 isoform X1

      UniProtKB/Swiss-Prot
      Q07352, Q13851
      UniProtKB/TrEMBL
      B3KNA8
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