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    MPHOSPH10 M-phase phosphoprotein 10 [ Homo sapiens (human) ]

    Gene ID: 10199, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MPHOSPH10provided by HGNC
    Official Full Name
    M-phase phosphoprotein 10provided by HGNC
    Primary source
    HGNC:HGNC:7213
    See related
    Ensembl:ENSG00000124383 MIM:605503; AllianceGenome:HGNC:7213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT90; MPP10; MPP10P; PPP1R106
    Summary
    This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 13.3), prostate (RPKM 12.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MPHOSPH10 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (71130634..71150101)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (71141674..71161134)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71357764..71377231)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71310886-71311700 Neighboring gene NANOG hESC enhancer GRCh37_chr2:71317686-71318275 Neighboring gene N-acetylglucosamine kinase Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:71330180-71330990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71345289-71345789 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71356582-71357440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16015 Neighboring gene methylmalonyl-CoA epimerase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16016 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:71384714-71384875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:71388687-71389348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411093-71411594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71411595-71412094 Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:71453663-71454163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:71477764-71478264 Neighboring gene uncharacterized LOC105374797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. Westendorf JM, et al. Mol Biol Cell, 1998 Feb. PMID 9450966, Free PMC Article
    2. UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis. Gan Y, et al. Redox Biol, 2023 Jun. PMID 37087976, Free PMC Article
    3. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Granneman S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655004, Free PMC Article
    4. Identification of novel M phase phosphoproteins by expression cloning. Matsumoto-Taniura N, et al. Mol Biol Cell, 1996 Sep. PMID 8885239, Free PMC Article
    5. Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins. Nasa I, et al. Sci Signal, 2018 May 15. PMID 29764992, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA splicing, via transesterification reactions NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mpp10 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of sno(s)RNA-containing ribonucleoprotein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U3 small nucleolar ribonucleoprotein protein MPP10
    Names
    U3 small nucleolar ribonucleoprotein
    m phase phosphoprotein 10
    protein phosphatase 1, regulatory subunit 106

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005791.3 → NP_005782.1  U3 small nucleolar ribonucleoprotein protein MPP10

      See identical proteins and their annotated locations for NP_005782.1

      Status: REVIEWED

      Source sequence(s)
      BC041084, BC126389
      Consensus CDS
      CCDS1916.1
      UniProtKB/Swiss-Prot
      A0AVJ8, O00566
      UniProtKB/TrEMBL
      B3KPV5
      Related
      ENSP00000244230.2, ENST00000244230.7
      Conserved Domains (1) summary
      pfam04006
      Location:22 → 632
      Mpp10; Mpp10 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      71130634..71150101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      71141674..71161134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00566.2 GenPept UniProtKB/Swiss-Prot:O00566

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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