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    RAB6B RAB6B, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 51560, updated on 10-Dec-2024

    Summary

    Official Symbol
    RAB6Bprovided by HGNC
    Official Full Name
    RAB6B, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:14902
    See related
    Ensembl:ENSG00000154917 MIM:615852; AllianceGenome:HGNC:14902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables myosin V binding activity. Involved in Golgi organization and protein localization to Golgi membrane. Located in Golgi membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 76.4), heart (RPKM 6.6) and 1 other tissue See more
    Orthologs
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    Genomic context

    See RAB6B in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (133824235..133895882, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (136569430..136641051, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133543079..133614726, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transferrin Neighboring gene uncharacterized LOC105374116 Neighboring gene ACSL3 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:133513906-133514490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20559 Neighboring gene SRP receptor subunit beta Neighboring gene ReSE screen-validated silencer GRCh37_chr3:133554421-133554601 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:133558716-133559216 Neighboring gene NANOG hESC enhancer GRCh37_chr3:133573718-133574219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:133576178-133576792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133661421-133662009 Neighboring gene Sharpr-MPRA regulatory region 14374 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:133667965-133668933 Neighboring gene chromosome 3 putative open reading frame 36 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674467-133674998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674999-133675528 Neighboring gene solute carrier organic anion transporter family member 2A1 Neighboring gene Sharpr-MPRA regulatory region 8475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133748764-133749264

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (14 hits/1260 screens)

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables myosin V binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi apparatus PubMed 
    located_in Golgi membrane PubMed 
    located_in cytoplasmic vesicle  
    located_in cytosol  
    is_active_in endomembrane system  
    located_in endoplasmic reticulum-Golgi intermediate compartment  
    located_in presynapse  

    General protein information

    Preferred Names
    ras-related protein Rab-6B
    Names
    small GTP-binding protein
    small GTPase RAB6B
    NP_001350882.1
    NP_057661.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363953.1 → NP_001350882.1  ras-related protein Rab-6B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC080128, AF166492, AK295451, BC078662, DA221889
      Consensus CDS
      CCDS87137.1
      UniProtKB/TrEMBL
      Q6AZ91
      Related
      ENSP00000419381.1, ENST00000486858.5
      Conserved Domains (1) summary
      cd01861
      Location:11 → 161
      Rab6; Rab GTPase family 6 (Rab6)
    2. NM_016577.4 → NP_057661.3  ras-related protein Rab-6B isoform 1

      See identical proteins and their annotated locations for NP_057661.3

      Status: VALIDATED

      Source sequence(s)
      AC080128, AF166492, DA221889
      Consensus CDS
      CCDS3082.1
      UniProtKB/Swiss-Prot
      B2R5Z9, B7Z337, D3DND3, Q92929, Q9NRW1
      UniProtKB/TrEMBL
      Q6AZ91
      Related
      ENSP00000285208.4, ENST00000285208.9
      Conserved Domains (1) summary
      cd01861
      Location:14 → 174
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      133824235..133895882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      136569430..136641051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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