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    ANAPC10 anaphase promoting complex subunit 10 [ Homo sapiens (human) ]

    Gene ID: 10393, updated on 10-Dec-2024

    Summary

    Official Symbol
    ANAPC10provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 10provided by HGNC
    Primary source
    HGNC:HGNC:24077
    See related
    Ensembl:ENSG00000164162 MIM:613745; AllianceGenome:HGNC:24077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOC1; APC10
    Summary
    ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
    Expression
    Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ANAPC10 in Genome Data Viewer
    Location:
    4q31.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (144994575..145098571, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (148311947..148415963, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (145915727..146019723, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900792 Neighboring gene uncharacterized LOC124900793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15722 Neighboring gene RN7SK pseudogene 235 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:146018722-146019921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21962 Neighboring gene ATP binding cassette subfamily E member 1 Neighboring gene OTU deubiquitinase 4 Neighboring gene MPRA-validated peak5130 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21963 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146100843-146101672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146101673-146102502 Neighboring gene uncharacterized LOC124900794

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (650 hits/1288 screens)

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • DKFZp564L0562

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of anaphase-promoting complex  
    part_of anaphase-promoting complex PubMed 
    part_of anaphase-promoting complex PubMed 
    part_of anaphase-promoting complex PubMed 
    located_in cytosol  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 10
    Names
    cyclosome subunit 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256706.2 → NP_001243635.1  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_001243635.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC097649, AF132794, AL080090, BF693880, BU175327
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000423995.1, ENST00000507656.6
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    2. NM_001256707.2 → NP_001243636.1  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_001243636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC097649, AL080090, BF693880, CV023091
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000403891.2, ENST00000451299.6
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    3. NM_001256708.2 → NP_001243637.1  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_001243637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC096757, AC097649, BU567906, CV023091
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000478501.1, ENST00000613466.4
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    4. NM_001256709.2 → NP_001243638.1  anaphase-promoting complex subunit 10 isoform 2

      See identical proteins and their annotated locations for NP_001243638.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, AL080090, BF693880, BG494966
      UniProtKB/TrEMBL
      D6RA92
      Conserved Domains (1) summary
      pfam03256
      Location:15 → 194
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    5. NM_001256710.2 → NP_001243639.1  anaphase-promoting complex subunit 10 isoform 3

      See identical proteins and their annotated locations for NP_001243639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, AL080090, BF693880, CN305215
      UniProtKB/TrEMBL
      A0A3B3ISY7
      Related
      ENSP00000423223.1, ENST00000504721.5
      Conserved Domains (1) summary
      cl02148
      Location:4 → 109
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    6. NM_001256711.2 → NP_001243640.1  anaphase-promoting complex subunit 10 isoform 3

      See identical proteins and their annotated locations for NP_001243640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, BF693880, BG530912, CN305215
      UniProtKB/TrEMBL
      A0A3B3ISY7
      Conserved Domains (1) summary
      cl02148
      Location:4 → 109
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    7. NM_001256712.2 → NP_001243641.1  anaphase-promoting complex subunit 10 isoform 4

      See identical proteins and their annotated locations for NP_001243641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, AV757106, BF693880
      UniProtKB/TrEMBL
      D6RB36
      Conserved Domains (1) summary
      cl02148
      Location:4 → 69
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    8. NM_001318367.2 → NP_001305296.1  anaphase-promoting complex subunit 10 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) contains an alternate 5' terminal exon compared to variant 1. This difference results in a distinct 5' UTR, translation initiation at an alternate start codon, and a novel 5' coding region compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB012109, AC096757, AC097649, AW025455, BI913723
      UniProtKB/Swiss-Prot
      Q9UM13
      Conserved Domains (1) summary
      pfam03256
      Location:38 → 217
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    9. NM_014885.5 → NP_055700.2  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_055700.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AB012109, AC097649
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000310071.5, ENST00000309439.9
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    RNA

    1. NR_046345.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC097649, BF693880, BI488888

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      144994575..145098571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531531.4 → XP_011529833.2  anaphase-promoting complex subunit 10 isoform X8

      UniProtKB/TrEMBL
      D6RB36
      Related
      ENSP00000424463.1, ENST00000502847.1
    2. XM_047449503.1 → XP_047305459.1  anaphase-promoting complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      D6RA92
    3. XM_047449507.1 → XP_047305463.1  anaphase-promoting complex subunit 10 isoform X9

    4. XM_047449502.1 → XP_047305458.1  anaphase-promoting complex subunit 10 isoform X1

    5. XM_047449504.1 → XP_047305460.1  anaphase-promoting complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      D6RA92
    6. XM_017007639.3 → XP_016863128.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      pfam03256
      Location:38 → 217
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    7. XM_011531525.3 → XP_011529827.2  anaphase-promoting complex subunit 10 isoform X3

    8. XM_017007642.2 → XP_016863131.1  anaphase-promoting complex subunit 10 isoform X6

    9. XM_017007641.2 → XP_016863130.1  anaphase-promoting complex subunit 10 isoform X4

    10. XM_047449505.1 → XP_047305461.1  anaphase-promoting complex subunit 10 isoform X5

      UniProtKB/TrEMBL
      A0A3B3ISY7, D6RD74
      Related
      ENSP00000425459.1, ENST00000512680.5
    11. XM_047449506.1 → XP_047305462.1  anaphase-promoting complex subunit 10 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      148311947..148415963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348736.1 → XP_054204711.1  anaphase-promoting complex subunit 10 isoform X8

      UniProtKB/TrEMBL
      D6RB36
    2. XM_054348729.1 → XP_054204704.1  anaphase-promoting complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      D6RA92
    3. XM_054348737.1 → XP_054204712.1  anaphase-promoting complex subunit 10 isoform X9

    4. XM_054348727.1 → XP_054204702.1  anaphase-promoting complex subunit 10 isoform X1

    5. XM_054348730.1 → XP_054204705.1  anaphase-promoting complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      D6RA92
    6. XM_054348728.1 → XP_054204703.1  anaphase-promoting complex subunit 10 isoform X1

    7. XM_054348731.1 → XP_054204706.1  anaphase-promoting complex subunit 10 isoform X3

    8. XM_054348734.1 → XP_054204709.1  anaphase-promoting complex subunit 10 isoform X6

    9. XM_054348732.1 → XP_054204707.1  anaphase-promoting complex subunit 10 isoform X4

    10. XM_054348733.1 → XP_054204708.1  anaphase-promoting complex subunit 10 isoform X5

      UniProtKB/TrEMBL
      A0A3B3ISY7, D6RD74
    11. XM_054348735.1 → XP_054204710.1  anaphase-promoting complex subunit 10 isoform X7

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