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    CD276 CD276 molecule [ Homo sapiens (human) ]

    Gene ID: 80381, updated on 10-Dec-2024

    Summary

    Official Symbol
    CD276provided by HGNC
    Official Full Name
    CD276 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:19137
    See related
    Ensembl:ENSG00000103855 MIM:605715; AllianceGenome:HGNC:19137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
    Summary
    The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CD276 in Genome Data Viewer
    Location:
    15q24.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (73683944..73714514)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (71501041..71531847)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73976724..74006855)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NPTN intronic transcript 1 Neighboring gene neuroplastin Neighboring gene ReSE screen-validated silencer GRCh37_chr15:73879798-73879963 Neighboring gene NANOG hESC enhancer GRCh37_chr15:73909554-73910143 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:73910157-73910718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6634 Neighboring gene uncharacterized LOC105370891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:73975613-73976121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6637 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:73977139-73977645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73988434-73988945 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:73988946-73989458 and GRCh37_chr15:73989459-73989969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73994347-73995068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74043809-74044582 Neighboring gene inhibitory synaptic factor 1 Neighboring gene INSYN1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (21 hits/1280 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.
    EBI GWAS Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    located_in membrane PubMed 

    General protein information

    Preferred Names
    CD276 antigen
    Names
    B7 homolog 3
    costimulatory molecule

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051242.1 RefSeqGene

      Range
      5418..35549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024736.2 → NP_001019907.1  CD276 antigen isoform a precursor

      See identical proteins and their annotated locations for NP_001019907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK075549, BC062581, CA420873
      Consensus CDS
      CCDS32288.1
      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
      Related
      ENSP00000320084.5, ENST00000318443.10
      Conserved Domains (2) summary
      smart00410
      Location:156 → 237
      IG_like; Immunoglobulin like
      cl11960
      Location:261 → 357
      Ig; Immunoglobulin domain
    2. NM_001329628.2 → NP_001316557.1  CD276 antigen isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC022188, AC100838, CA420873
      Consensus CDS
      CCDS10251.1
      UniProtKB/Swiss-Prot
      Q5ZPR3
    3. NM_001329629.2 → NP_001316558.1  CD276 antigen isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform a.
      Source sequence(s)
      AK292711, BC011578, BC062581, CA420873
      Consensus CDS
      CCDS86475.1
      UniProtKB/TrEMBL
      A0A0C4DGH0, A8K9J6
      Related
      ENSP00000441087.2, ENST00000537340.6
      Conserved Domains (2) summary
      smart00410
      Location:10 → 91
      IG_like; Immunoglobulin like
      cl11960
      Location:115 → 211
      Ig; Immunoglobulin domain
    4. NM_025240.3 → NP_079516.1  CD276 antigen isoform b precursor

      See identical proteins and their annotated locations for NP_079516.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AF302102, AK075549, BC062581, CA420873
      Consensus CDS
      CCDS10251.1
      UniProtKB/Swiss-Prot
      Q5ZPR3
      Related
      ENSP00000320058.5, ENST00000318424.9
      Conserved Domains (2) summary
      smart00410
      Location:156 → 238
      IG_like; Immunoglobulin like
      cl11960
      Location:43 → 139
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      73683944..73714514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022638.2 → XP_016878127.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
      Conserved Domains (2) summary
      smart00410
      Location:156 → 237
      IG_like; Immunoglobulin like
      cl11960
      Location:261 → 357
      Ig; Immunoglobulin domain
    2. XM_011522095.3 → XP_011520397.1  CD276 antigen isoform X1

      See identical proteins and their annotated locations for XP_011520397.1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
      Conserved Domains (2) summary
      smart00410
      Location:156 → 237
      IG_like; Immunoglobulin like
      cl11960
      Location:261 → 357
      Ig; Immunoglobulin domain
    3. XM_005254700.5 → XP_005254757.1  CD276 antigen isoform X1

      See identical proteins and their annotated locations for XP_005254757.1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
      Conserved Domains (2) summary
      smart00410
      Location:156 → 237
      IG_like; Immunoglobulin like
      cl11960
      Location:261 → 357
      Ig; Immunoglobulin domain
    4. XM_047433148.1 → XP_047289104.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
    5. XM_047433147.1 → XP_047289103.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      71501041..71531847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378932.1 → XP_054234907.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
    2. XM_054378929.1 → XP_054234904.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
    3. XM_054378930.1 → XP_054234905.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
    4. XM_054378931.1 → XP_054234906.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
    5. XM_054378928.1 → XP_054234903.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
      UniProtKB/TrEMBL
      A8K6Q6
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