Ocln occludin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oclnprovided by RGD
Official Full Name: occludinprovided by RGD
Primary source: RGD:620089
See related: EnsemblRapid:ENSRNOG00000071323 AllianceGenome:RGD:620089
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein domain specific binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to Gram-positive bacterium; and response to interleukin-18. Located in apical plasma membrane and lateral plasma membrane. Biomarker of diabetic retinopathy and metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 177.7), Lung (RPKM 119.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (33391303..33442207, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (31657217..31707466, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (30527327..30577218, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats.
Title: Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats.
Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model.
Title: Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model.
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Title: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1.
Title: Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1.
The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats.
Title: The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats.
we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels.
Title: Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats.
Study, found that the stimulation of alpha7 nicotinic acetylcholine receptor but not alpha4beta2 nicotinic acetylcholine receptor decreased sodium-fluorescein permeability and increased cell transendothelial electrical resistance in rat brain endothelial cells (RBEC) monolayers and increased the protein levels of claudin-5 and occludin in RBECs.
Title: Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells.
The TLR4/PKCalpha/occludin signaling pathway was closely related to blood-brain barrier damage.
Title: TLR4/PKCα/occludin signaling pathway may be related to blood‑brain barrier damage.
blood occludin levels correlate well with the extent of blood brain barrie damage.
Title: Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke.
Both upregulation of claudin-4 and downregulation of occludin might increase paracellular NaCl transport in the kidney, resulting in impaired pressure natriuresis in SS rats.
Title: Alteration of Tight Junction Protein Expression in Dahl Salt-Sensitive Rat Kidney.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ocln (e-PCR), detects polymorphism
- UniSTS:495893

D2Rat193 (e-PCR), detects polymorphism
- UniSTS:227354

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-18	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tight junction organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	NAS Non-traceable Author Statement more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: occludin

NP_112619.2

EC 2.1.1.67

XP_006231915.1

EC 2.1.1.67

XP_006231916.1

EC 2.1.1.67

XP_006231917.1

EC 2.1.1.67

XP_038959170.1

EC 2.1.1.67

XP_038959172.1

EC 2.1.1.67

XP_038959173.1

EC 2.1.1.67

XP_063138706.1

EC 2.1.1.67

XP_063138707.1

EC 2.1.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031329.3 → NP_112619.2 occludin

See identical proteins and their annotated locations for NP_112619.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q6P6T5, Q9Z303

UniProtKB/TrEMBL

A0A8L2QZI9, A6I594

Related

ENSRNOP00000098588.1, ENSRNOT00000121036.2

Conserved Domains (2) summary

pfam01284
Location:57 → 263

MARVEL; Membrane-associating domain

pfam07303
Location:421 → 520

Occludin_ELL; Occludin homology domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

33391303..33442207 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103242.2 → XP_038959170.1 occludin isoform X1

UniProtKB/Swiss-Prot

Q6P6T5, Q9Z303

UniProtKB/TrEMBL

A0A8L2QZI9, A6I594

Conserved Domains (2) summary

pfam01284
Location:57 → 263

MARVEL; Membrane-associating domain

pfam07303
Location:421 → 520

Occludin_ELL; Occludin homology domain
XM_063282637.1 → XP_063138707.1 occludin isoform X2

UniProtKB/TrEMBL

A0A8L2QZI9
XM_006231853.5 → XP_006231915.1 occludin isoform X1

See identical proteins and their annotated locations for XP_006231915.1

UniProtKB/Swiss-Prot

Q6P6T5, Q9Z303

UniProtKB/TrEMBL

A0A8L2QZI9, A6I594

Conserved Domains (2) summary

pfam01284
Location:57 → 263

MARVEL; Membrane-associating domain

pfam07303
Location:421 → 520

Occludin_ELL; Occludin homology domain
XM_039103245.2 → XP_038959173.1 occludin isoform X2

UniProtKB/TrEMBL

A0A8L2QZI9

Conserved Domains (2) summary

pfam01284
Location:57 → 213

MARVEL; Membrane-associating domain

pfam07303
Location:367 → 466

Occludin_ELL; Occludin homology domain
XM_006231854.5 → XP_006231916.1 occludin isoform X1

See identical proteins and their annotated locations for XP_006231916.1

UniProtKB/Swiss-Prot

Q6P6T5, Q9Z303

UniProtKB/TrEMBL

A0A8L2QZI9, A6I594

Conserved Domains (2) summary

pfam01284
Location:57 → 263

MARVEL; Membrane-associating domain

pfam07303
Location:421 → 520

Occludin_ELL; Occludin homology domain
XM_039103244.2 → XP_038959172.1 occludin isoform X1

UniProtKB/Swiss-Prot

Q6P6T5, Q9Z303

UniProtKB/TrEMBL

A0A8L2QZI9, A6I594

Conserved Domains (2) summary

pfam01284
Location:57 → 263

MARVEL; Membrane-associating domain

pfam07303
Location:421 → 520

Occludin_ELL; Occludin homology domain
XM_006231855.5 → XP_006231917.1 occludin isoform X1

See identical proteins and their annotated locations for XP_006231917.1

UniProtKB/Swiss-Prot

Q6P6T5, Q9Z303

UniProtKB/TrEMBL

A0A8L2QZI9, A6I594

Conserved Domains (2) summary

pfam01284
Location:57 → 263

MARVEL; Membrane-associating domain

pfam07303
Location:421 → 520

Occludin_ELL; Occludin homology domain
XM_063282636.1 → XP_063138706.1 occludin isoform X1

UniProtKB/Swiss-Prot

Q6P6T5, Q9Z303

UniProtKB/TrEMBL

A0A8L2QZI9, A6I594