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    Fbxl20 F-box and leucine-rich repeat protein 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64039, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fbxl20provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 20provided by RGD
    Primary source
    RGD:621722
    See related
    EnsemblRapid:ENSRNOG00000083773 AllianceGenome:RGD:621722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbl2; Fbxl2
    Summary
    Predicted to be involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within behavioral fear response. Predicted to be located in presynapse. Predicted to be active in Schaffer collateral - CA1 synapse; cytoplasm; and glutamatergic synapse. Orthologous to human FBXL20 (F-box and leucine rich repeat protein 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 53.6), Lung (RPKM 47.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl20 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83577038..83640022, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83080568..83143680, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86036745..86099699, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene uncharacterized LOC102548674 Neighboring gene mediator complex subunit 1 Neighboring gene cyclin-dependent kinase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins. Wang W, et al. J Affect Disord, 2024 Mar 15. PMID 38211741
    2. Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice. Yao I, et al. PLoS One, 2011 Feb 24. PMID 21390313, Free PMC Article
    3. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. Ilyin GP, et al. FEBS Lett, 1999 Oct 1. PMID 10508920
    4. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Yao I, et al. Cell, 2007 Sep 7. PMID 17803915, Free PMC Article
    5. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins.
      Title: FBXL20 promotes synaptic impairment in depression disorder via degrading vesicle-associated proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein catabolic process at presynapse, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 20
    Names
    F-box protein FBL2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401500.2 → NP_001388429.1  F-box/LRR-repeat protein 20

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0H2UI14, A0A8I6AIN4
      Related
      ENSRNOP00000103590.1, ENSRNOT00000140962.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83577038..83640022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086778.2 → XP_038942706.1  F-box/LRR-repeat protein 20 isoform X5

      UniProtKB/TrEMBL
      A0A0H2UI14, A6HIQ3
      Related
      ENSRNOP00000110960.1, ENSRNOT00000171192.1
      Conserved Domains (3) summary
      cd09293
      Location:222 → 396
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:121 → 146
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:30 → 71
      F-box-like

    2. XM_039086781.2 → XP_038942709.1  F-box/LRR-repeat protein 20 isoform X7

      UniProtKB/TrEMBL
      A0A0H2UI14
      Conserved Domains (3) summary
      cd09293
      Location:206 → 380
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:105 → 130
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:14 → 55
      F-box-like

    3. XM_017597519.3 → XP_017453008.1  F-box/LRR-repeat protein 20 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UI14, A0A8I6A9E5
      Related
      ENSRNOP00000102976.1, ENSRNOT00000146752.1

    4. XM_039086782.2 → XP_038942710.1  F-box/LRR-repeat protein 20 isoform X7

      UniProtKB/TrEMBL
      A0A0H2UI14
      Conserved Domains (3) summary
      cd09293
      Location:206 → 380
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:105 → 130
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:14 → 55
      F-box-like

    5. XM_039086780.2 → XP_038942708.1  F-box/LRR-repeat protein 20 isoform X7

      UniProtKB/TrEMBL
      A0A0H2UI14
      Related
      ENSRNOP00000109320.1, ENSRNOT00000142853.1
      Conserved Domains (3) summary
      cd09293
      Location:206 → 380
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:105 → 130
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:14 → 55
      F-box-like

    6. XM_063269799.1 → XP_063125869.1  F-box/LRR-repeat protein 20 isoform X3

    7. XM_063269801.1 → XP_063125871.1  F-box/LRR-repeat protein 20 isoform X6

    8. XM_063269800.1 → XP_063125870.1  F-box/LRR-repeat protein 20 isoform X4

    9. XM_063269798.1 → XP_063125868.1  F-box/LRR-repeat protein 20 isoform X1

    10. XM_063269804.1 → XP_063125874.1  F-box/LRR-repeat protein 20 isoform X6

    11. XM_063269802.1 → XP_063125872.1  F-box/LRR-repeat protein 20 isoform X6

    12. XM_063269803.1 → XP_063125873.1  F-box/LRR-repeat protein 20 isoform X8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022272.1: Suppressed sequence

      Description
      NM_022272.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZH7.1 GenPept UniProtKB/Swiss-Prot:Q9QZH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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