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    Bdkrb1 bradykinin receptor B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81509, updated on 4-Jan-2025

    Summary

    Official Symbol
    Bdkrb1provided by RGD
    Official Full Name
    bradykinin receptor B1provided by RGD
    Primary source
    RGD:620401
    See related
    EnsemblRapid:ENSRNOG00000004488 AllianceGenome:RGD:620401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BKR; Bdkrb; b1bkr
    Summary
    Enables bradykinin receptor activity and peptide binding activity. Involved in several processes, including negative regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; and response to lipopolysaccharide. Predicted to be active in plasma membrane. Used to study several diseases, including diabetic angiopathy; hypertension; neuropathy (multiple); overactive bladder syndrome; and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Uterus (RPKM 5.6), Adrenal (RPKM 1.6) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bdkrb1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (130275631..130284968)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (124510827..124514475)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129437423..129441553)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479471 Neighboring gene uncharacterized LOC134479470 Neighboring gene uncharacterized LOC120103615 Neighboring gene bradykinin receptor B2 Neighboring gene autophagy related 2B Neighboring gene uncharacterized LOC134479256 Neighboring gene GSK3B interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bradykinin receptor activity  
    enables bradykinin receptor activity PubMed 
    enables bradykinin receptor activity  
    enables peptide binding PubMed 
    enables peptide binding  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in cell migration PubMed 
    involved_in cyclooxygenase pathway  
    involved_in inflammatory response  
    involved_in negative regulation of blood pressure PubMed 
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of protein phosphorylation PubMed 
    involved_in positive regulation of leukocyte migration PubMed 
    NOT involved_in positive regulation of release of sequestered calcium ion into cytosol PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol PubMed 
    involved_in response to lipopolysaccharide PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide  
    involved_in response to mechanical stimulus  
    involved_in smooth muscle relaxation of the bladder outlet  
    Component Evidence Code Pubs
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    B1 bradykinin receptor
    Names
    B1R
    BK-1 receptor
    KB1
    bradykinin B1 receptor
    bradykinin receptor, beta 1
    kinin B1 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030851.1NP_110478.1  B1 bradykinin receptor

      See identical proteins and their annotated locations for NP_110478.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ132230
      UniProtKB/Swiss-Prot
      O35782, P97583, Q9R250
      UniProtKB/TrEMBL
      A6KBC8
      Related
      ENSRNOP00000005953.2, ENSRNOT00000005953.5
      Conserved Domains (1) summary
      pfam00001
      Location:80322
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      130275631..130284968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764861.4XP_008763083.1  B1 bradykinin receptor isoform X1

      See identical proteins and their annotated locations for XP_008763083.1

      UniProtKB/Swiss-Prot
      O35782, P97583, Q9R250
      UniProtKB/TrEMBL
      A6KBC8
      Conserved Domains (1) summary
      pfam00001
      Location:80322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
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