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    Ago2 argonaute RISC catalytic component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59117, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ago2provided by RGD
    Official Full Name
    argonaute RISC catalytic component 2provided by RGD
    Primary source
    RGD:621255
    See related
    EnsemblRapid:ENSRNOG00000008533 AllianceGenome:RGD:621255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eif2c2; eIF2C 2
    Summary
    Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and RISC complex binding activity. Involved in several processes, including regulation of macromolecule biosynthetic process; response to cocaine; and response to morphine. Located in several cellular components, including Golgi apparatus; cytoplasmic ribonucleoprotein granule; and dendrite. Part of RISC complex. Biomarker of morphine dependence and withdrawal disorder. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 251.5), Muscle (RPKM 174.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ago2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (106907209..106994124, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (105018202..105105118, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (114339607..114377277, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 9 Neighboring gene uncharacterized LOC134479749 Neighboring gene uncharacterized LOC134479922 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151b Neighboring gene uncharacterized LOC134479923 Neighboring gene microRNA 151

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 40
    Function Evidence Code Pubs
    enables Hsp70 protein binding PubMed 
    enables Hsp90 protein binding PubMed 
    enables RISC complex binding PubMed 
    enables RNA 7-methylguanosine cap binding  
    enables RNA 7-methylguanosine cap binding  
    enables RNA 7-methylguanosine cap binding  
    enables RNA binding  
    enables RNA binding  
    enables RNA endonuclease activity  
    enables RNA endonuclease activity  
    enables RNA polymerase II complex binding  
    enables RNA polymerase II complex binding  
    enables core promoter sequence-specific DNA binding  
    enables core promoter sequence-specific DNA binding  
    enables double-stranded RNA binding  
    enables double-stranded RNA binding  
    enables endoribonuclease activity, cleaving miRNA-paired mRNA  
    enables endoribonuclease activity, cleaving miRNA-paired mRNA  
    enables endoribonuclease activity, cleaving siRNA-paired mRNA  
    enables endoribonuclease activity, cleaving siRNA-paired mRNA  
    enables endoribonuclease activity, cleaving siRNA-paired mRNA  
    enables hydrolase activity  
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA binding  
    enables mRNA cap binding  
    enables mRNA cap binding  
    enables mRNA cap binding  
    enables metal ion binding  
    enables miRNA binding  
    enables miRNA binding  
    enables miRNA binding  
    enables protein binding PubMed 
    enables siRNA binding  
    contributes_to siRNA binding  
    enables siRNA binding  
    enables siRNA binding  
    enables single-stranded RNA binding  
    enables single-stranded RNA binding  
    enables single-stranded RNA binding  
    Items 1 - 25 of 40
    Items 1 - 25 of 61
    Process Evidence Code Pubs
    involved_in P-body assembly  
    involved_in P-body assembly  
    involved_in RISC complex assembly  
    involved_in RISC complex assembly  
    involved_in RNA secondary structure unwinding  
    involved_in RNA secondary structure unwinding  
    involved_in cell differentiation PubMed 
    involved_in cellular response to calcium ion PubMed 
    involved_in miRNA metabolic process  
    acts_upstream_of_or_within miRNA metabolic process  
    acts_upstream_of_or_within miRNA processing  
    involved_in miRNA processing  
    involved_in miRNA-mediated gene silencing by inhibition of translation  
    involved_in miRNA-mediated gene silencing by inhibition of translation  
    involved_in miRNA-mediated gene silencing by inhibition of translation  
    involved_in miRNA-mediated gene silencing by mRNA destabilization  
    involved_in miRNA-mediated gene silencing by mRNA destabilization  
    involved_in miRNA-mediated gene silencing by mRNA destabilization  
    involved_in negative regulation of amyloid precursor protein biosynthetic process PubMed 
    involved_in negative regulation of translational initiation  
    involved_in negative regulation of translational initiation  
    involved_in negative regulation of translational initiation  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    involved_in positive regulation of post-transcriptional gene silencing by RNA PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of translation  
    involved_in positive regulation of translation  
    involved_in positive regulation of trophoblast cell migration  
    involved_in positive regulation of trophoblast cell migration  
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in pre-miRNA processing  
    involved_in pre-miRNA processing  
    involved_in pre-miRNA processing  
    involved_in pre-miRNA processing  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of mRNA stability PubMed 
    involved_in regulation of synapse maturation  
    involved_in regulation of synapse maturation  
    involved_in regulation of translation  
    involved_in regulatory ncRNA-mediated gene silencing  
    involved_in regulatory ncRNA-mediated gene silencing  
    involved_in regulatory ncRNA-mediated gene silencing  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing  
    involved_in response to cocaine PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to morphine PubMed 
    involved_in siRNA processing  
    involved_in siRNA processing  
    involved_in siRNA-mediated gene silencing by mRNA destabilization  
    involved_in siRNA-mediated gene silencing by mRNA destabilization  
    involved_in spermatogenesis PubMed 
    Items 1 - 25 of 61
    Items 1 - 20 of 41
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in P granule PubMed 
    located_in P-body  
    located_in P-body  
    part_of RISC complex  
    part_of RISC complex PubMed 
    part_of RISC complex  
    part_of RISC complex  
    part_of RISC complex  
    part_of RISC-loading complex  
    part_of RISC-loading complex  
    part_of RISC-loading complex  
    located_in chromatoid body PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic stress granule PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in dendrite  
    located_in extracellular exosome  
    located_in extracellular exosome  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in membrane PubMed 
    located_in mitochondrion PubMed 
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in pi-body PubMed 
    located_in postsynapse  
    is_active_in postsynapse  
    part_of ribonucleoprotein complex PubMed 
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 41

    General protein information

    Preferred Names
    protein argonaute-2
    Names
    argonaute 2, RISC catalytic component
    argonaute2
    eukaryotic translation initiation factor 2C 2
    golgi ER protein 95 kDa
    NP_001395847.1
    XP_038936149.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408918.2NP_001395847.1  protein argonaute-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9QZ81
      UniProtKB/TrEMBL
      F1LRP7
      Related
      ENSRNOP00000011898.4, ENSRNOT00000011898.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      106907209..106994124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080221.2XP_038936149.1  protein argonaute-2 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ81
      Related
      ENSRNOP00000095405.2, ENSRNOT00000120018.2
      Conserved Domains (4) summary
      cd02846
      Location:181301
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:346771
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:130180
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:46120
      ArgoN; N-terminal domain of argonaute

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