Pawr pro-apoptotic WT1 regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pawrprovided by RGD
Official Full Name: pro-apoptotic WT1 regulatorprovided by RGD
Primary source: RGD:69065
See related: EnsemblRapid:ENSRNOG00000005917 AllianceGenome:RGD:69065
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Par4; Par-4
Summary: Enables actin binding activity; protein kinase C binding activity; and protein phosphatase 1 binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; positive regulation of apoptotic process; and regulation of cellular extravasation. Located in actin filament; axon; and neuronal cell body. Biomarker of depressive disorder; epilepsy; middle cerebral artery infarction; and transient cerebral ischemia. Orthologous to human PAWR (pro-apoptotic WT1 regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 118.6), Lung (RPKM 80.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (45531480..45611492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (43645028..43725033)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (51273764..51353700, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that downregulation of iNOS, IL-1beta, and P2X7 expression in mast cells via activation of PAR4 contributes to the Inhibition of visceral hyperalgesia
Title: Downregulation of iNOS, IL-1β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats.
Phosphorylation by CK2 impairs Par-4 proapoptotic functions.
Title: Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.
Par-4 binding does not block MYPT1 phosphorylation in rat caudal arterial smooth muscle.
Title: Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.
Par-4 and caspase-3 immunoreactivity in specific brain areas including the hippocampus CA1, CA3 and dentate gyrus, the adjacent cortex and the striatum in adult and aged rats from control and neonatally ferrous iron (Fe+2)-treated groups.
Title: Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats.
PAR4 activation in the knee joint leads to mast cell-dependent changes in joint mechanosensitivity and pain behavior.
Title: The pronociceptive effect of proteinase-activated receptor-4 stimulation in rat knee joints is dependent on mast cell activation.
depression-like behaviors is associated with down-regulated Par-4 and dopamine receptor D2 gene expression in the striatum through a non-methylation mechanism
Title: Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum.
Par-4 is a new activator of myosin phosphatase
Title: Par-4: a new activator of myosin phosphatase.
Dlk-mediated phosphorylation of Par-4 at T155 is a crucial event in Dlk/Par-4-induced apoptosis.
Title: Par-4 is an essential downstream target of DAP-like kinase (Dlk) in Dlk/Par-4-mediated apoptosis.
Under physiological conditions, Par-4 self-associates via the C-terminal domain, forming a coiled-coil.
Title: Intrinsic disorder and coiled-coil formation in prostate apoptosis response factor 4.
Par-4 is a novel regulator of myosin light chain phosphorylation in differentiated, contractile vascular smooth muscle.
Title: The pro-apoptotic protein Par-4 facilitates vascular contractility by cytoskeletal targeting of ZIPK.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU047800 (e-PCR)
- UniSTS:110162

AU047769 (e-PCR)
- UniSTS:110187

RH129154 (e-PCR)
- UniSTS:212462

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables leucine zipper domain binding	IEA Inferred from Electronic Annotation more info
enables leucine zipper domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of action potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of amyloid precursor protein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hindgut contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte tethering or rolling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil extravasation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of relaxation of smooth muscle	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron(II) ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PRKC apoptosis WT1 regulator protein

Names: PRKC, apoptosis, WT1, regulator; Prostate apoptosis response protein 4; par-4 induced by effectors of apoptosis; prostate apoptosis response 4 protein; transcriptional repressor Par-4-like protein PAWR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033485.3 → NP_277020.2 PRKC apoptosis WT1 regulator protein

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q62627

UniProtKB/TrEMBL

A6IGE0

Related

ENSRNOP00000107478.1, ENSRNOT00000167387.1

Conserved Domains (1) summary

COG1196
Location:258 → 319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

45531480..45611492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241317.5 → XP_006241379.1 PRKC apoptosis WT1 regulator protein isoform X1

See identical proteins and their annotated locations for XP_006241379.1

UniProtKB/Swiss-Prot

Q62627

UniProtKB/TrEMBL

A6IGE0

Related

ENSRNOP00000085170.2, ENSRNOT00000113713.2

Conserved Domains (1) summary

COG1196
Location:258 → 319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_039079857.2 → XP_038935785.1 PRKC apoptosis WT1 regulator protein isoform X1

UniProtKB/Swiss-Prot

Q62627

UniProtKB/TrEMBL

A6IGE0

Conserved Domains (1) summary

COG1196
Location:258 → 319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]