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    Ankrd13a ankyrin repeat domain 13a [ Mus musculus (house mouse) ]

    Gene ID: 68420, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ankrd13aprovided by MGI
    Official Full Name
    ankyrin repeat domain 13aprovided by MGI
    Primary source
    MGI:MGI:1915670
    See related
    Ensembl:ENSMUSG00000041870 AllianceGenome:MGI:1915670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ANKRD13; 1100001D10Rik
    Summary
    Predicted to enable ubiquitin-modified protein reader activity. Predicted to be involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Predicted to be located in late endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in acoustic ganglion; endolymphatic appendage; and otocyst. Orthologous to human ANKRD13A (ankyrin repeat domain 13A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 63.8), colon adult (RPKM 53.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd13a in Genome Data Viewer
    Location:
    5 F; 5 55.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114913009..114943882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114774948..114805821)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene trichoplein, keratin filament binding Neighboring gene microRNA 7028 Neighboring gene GIT ArfGAP 2 Neighboring gene RIKEN cDNA 4930515G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E3602 Neighboring gene STARR-positive B cell enhancer ABC_E3603 Neighboring gene STARR-seq mESC enhancer starr_14089 Neighboring gene RIKEN cDNA 1500011B03 gene Neighboring gene RIKEN cDNA 2610524H06 gene Neighboring gene STARR-seq mESC enhancer starr_14090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB. Won M, et al. Cell Death Differ, 2022 Jun. PMID 34839354, Free PMC Article
    2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    3. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118502

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified protein reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 13A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378897.1 → NP_001365826.1  ankyrin repeat domain-containing protein 13A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087330
      UniProtKB/TrEMBL
      Q3U0V3
      Conserved Domains (3) summary
      sd00045
      Location:12 → 38
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:156 → 469
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:13 → 96
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_026718.2 → NP_080994.2  ankyrin repeat domain-containing protein 13A isoform 1

      See identical proteins and their annotated locations for NP_080994.2

      Status: VALIDATED

      Source sequence(s)
      BC061692
      Consensus CDS
      CCDS19572.1
      UniProtKB/Swiss-Prot
      Q2VPQ7, Q6P7F2, Q80UP5
      UniProtKB/TrEMBL
      Q3U0V3
      Related
      ENSMUSP00000099638.5, ENSMUST00000102578.11
      Conserved Domains (4) summary
      cd00204
      Location:4 → 101
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:156 → 468
      GPCR_chapero_1; GPCR-chaperone
      pfam13637
      Location:41 → 90
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:12 → 38
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      114913009..114943882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UP5.2 GenPept UniProtKB/Swiss-Prot:Q80UP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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