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    Otud6b OTU domain containing 6B [ Mus musculus (house mouse) ]

    Gene ID: 72201, updated on 3-Dec-2024

    Summary

    Official Symbol
    Otud6bprovided by MGI
    Official Full Name
    OTU domain containing 6Bprovided by MGI
    Primary source
    MGI:MGI:1919451
    See related
    Ensembl:ENSMUSG00000040550 AllianceGenome:MGI:1919451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600013N14Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including proteasome assembly; protein deubiquitination; and regulation of translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and liver and biliary system. Orthologous to human OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.1), CNS E11.5 (RPKM 11.8) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Otud6b in Genome Data Viewer
    Location:
    4 A1; 4 6.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (14809503..14826413, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (14809505..14826413, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09634 Neighboring gene STARR-seq mESC enhancer starr_09635 Neighboring gene solute carrier family 26, member 7 Neighboring gene STARR-seq mESC enhancer starr_09636 Neighboring gene leucine rich repeat containing 69 Neighboring gene STARR-seq mESC enhancer starr_09637 Neighboring gene STARR-positive B cell enhancer ABC_E6153 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene predicted gene 11837 Neighboring gene N-terminal EF-hand calcium binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103361

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 4F complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    deubiquitinase OTUD6B
    Names
    OTU domain-containing protein 6B
    ortholog of human CGI-77
    NP_001402950.1
    NP_690025.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416021.1NP_001402950.1  deubiquitinase OTUD6B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831792
      UniProtKB/TrEMBL
      A0A0A0MQF5
    2. NM_152812.5NP_690025.3  deubiquitinase OTUD6B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL831792
      Consensus CDS
      CCDS17980.3
      UniProtKB/Swiss-Prot
      A2AP24, Q3T9X5, Q3U1R9, Q8K2H2
      UniProtKB/TrEMBL
      A0A0A0MQF5
      Related
      ENSMUSP00000113553.3, ENSMUST00000117268.9
      Conserved Domains (2) summary
      COG5539
      Location:3281
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
      pfam02338
      Location:154279
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      14809503..14826413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)