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    Cdk18 cyclin dependent kinase 18 [ Mus musculus (house mouse) ]

    Gene ID: 18557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk18provided by MGI
    Official Full Name
    cyclin dependent kinase 18provided by MGI
    Primary source
    MGI:MGI:97518
    See related
    Ensembl:ENSMUSG00000026437 AllianceGenome:MGI:97518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctk18; Pctk3
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and lung. Orthologous to human CDK18 (cyclin dependent kinase 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 63.9), small intestine adult (RPKM 44.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdk18 in Genome Data Viewer
    Location:
    1 E4; 1 57.24 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132041285..132067433, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132113547..132139698, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998691-133998892 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998935-133999044 Neighboring gene predicted gene, 37120 Neighboring gene predicted gene, 30153 Neighboring gene predicted gene, 30242

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PCTAIRE kinase 3/cyclin-dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A. Matsuda S, et al. J Biol Chem, 2014 Jun 27. PMID 24831015, Free PMC Article
    2. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. Okuda T, et al. Genomics, 1994 May 1. PMID 8088790
    3. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Okuda T, et al. Oncogene, 1992 Nov. PMID 1437147
    4. Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation. Rhee K, et al. Dev Dyn, 1995 Dec. PMID 8601034
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The activity of PCTK3 is increased via interaction with cyclin A2 and phosphorylation by PKA.
      Title: PCTAIRE kinase 3/cyclin-dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 18
    Names
    PCTAIRE-motif protein kinase 3
    cell division protein kinase 18
    serine/threonine-protein kinase PCTAIRE-3
    NP_032821.1
    XP_011246242.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008795.2 → NP_032821.1  cyclin-dependent kinase 18

      See identical proteins and their annotated locations for NP_032821.1

      Status: VALIDATED

      Source sequence(s)
      AK004998, BQ177094, CJ070016
      Consensus CDS
      CCDS15281.1
      UniProtKB/Swiss-Prot
      Q04899
      UniProtKB/TrEMBL
      Q0VDL6
      Related
      ENSMUSP00000027697.6, ENSMUST00000027697.12
      Conserved Domains (2) summary
      PLN00009
      Location:118 → 407
      PLN00009; cyclin-dependent kinase A; Provisional
      cl21453
      Location:115 → 402
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132041285..132067433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247940.4 → XP_011246242.1  cyclin-dependent kinase 18 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:38 → 325
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_387152.5 RNA Sequence

    2. XR_001783189.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04899.1 GenPept UniProtKB/Swiss-Prot:Q04899

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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