Oat ornithine aminotransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oatprovided by MGI
Official Full Name: ornithine aminotransferaseprovided by MGI
Primary source: MGI:MGI:97394
See related: Ensembl:ENSMUSG00000030934 AllianceGenome:MGI:97394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rhg
Summary: Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in arginine catabolic process to glutamate and arginine catabolic process to proline via ornithine. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and sensory organ. Used to study gyrate atrophy. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 563.9), large intestine adult (RPKM 200.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 76.3 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (132159204..132178127, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (132557475..132576398, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-beta1 activity.
Title: Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity.
CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation.
Title: CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation.
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer.
Title: Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer.
The data highlight the importance of OAT in ornithine metabolism, especially in the liver, and suggest a post-transcriptional regulation of OAT by LPS in the liver.
Title: Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase.
Sexual dimorphism of Oat expression in the kidney was observed.
Title: Sex-differential expression of ornithine aminotransferase in the mouse kidney.
in female and castrated male mice devoided of testosterone, OAT gene is highly expressed and L-ornithine is converted into L-glutamate.
Title: Testosterone down-regulates ornithine aminotransferase gene and up-regulates arginase II and ornithine decarboxylase genes for polyamines synthesis in the murine kidney.
In H4Flox liver, glutamine synthetase (GS), ornithine aminotransferase (OAT) and thyroid hormone-receptor beta1 (TRbeta1) were exclusively expressed in pericentral hepatocytes.
Title: Hepatic HNF4alpha deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Spontaneous (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127469 (e-PCR)
- UniSTS:210779

AI194874 (e-PCR)
- UniSTS:163428

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ornithine aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine aminotransferase activity	ISO Inferred from Sequence Orthology more info
enables ornithine aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process to glutamate	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process to proline via ornithine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ornithine aminotransferase, mitochondrial

Names: ornithine--oxo-acid aminotransferase

NP_058674.1

EC 2.6.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.