Loxl3 lysyl oxidase-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Loxl3provided by MGI
Official Full Name: lysyl oxidase-like 3provided by MGI
Primary source: MGI:MGI:1337004
See related: Ensembl:ENSMUSG00000000693 AllianceGenome:MGI:1337004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lor2; Loxl2
Summary: Enables fibronectin binding activity and protein-lysine 6-oxidase activity. Involved in several processes, including fibronectin fibril organization; negative regulation of T-helper 17 cell lineage commitment; and peptidyl-lysine oxidation. Located in extracellular space. Is expressed in several structures, including alimentary system; connective tissue; limb mesenchyme; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL3 (lysyl oxidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 18.2), bladder adult (RPKM 8.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83011186..83029547)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83034205..83052566)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase.
Title: Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase.
Progressive degeneration of the retina in Loxl3 mutant mouse model of Stickler syndrome.
Title: Progressive degeneration of the retina in Loxl3 mutant mouse model of Stickler syndrome.
Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.
Title: Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.
loss of LOXL3 attenuates mouse embryonic lung development.
Title: Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.
By deacetylating and deacetyliminating Stat3 on multiple acetyl-lysine sites in nuclei, Loxl3 regulates Stat3 dimerization and transcriptional activity. CD4+ T cell differentiation in inflammatory responses is regulated by the Loxl3-Stat3 signaling pathway
Title: Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.
evidence that LOXL3 is indispensable for mouse palatogenesis and vertebral column development
Title: Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice.
that lysyl oxidase-like 3 is a key regulator of integrin signaling that ensures localized control of the cascade
Title: Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6UmiJ26 (e-PCR), detects polymorphism
- UniSTS:260419

Loxl3 (e-PCR), detects polymorphism
- UniSTS:507975

MARC_4349-4350:991938479:1 (e-PCR)
- UniSTS:231082

MARC_4349-4350:996679540:1 (e-PCR)
- UniSTS:231082

AI481710 (e-PCR)
- UniSTS:179401

RH124140 (e-PCR)
- UniSTS:161004

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine 6-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine 6-oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine 6-oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibronectin fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T-helper 17 cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysyl oxidase homolog 3

Names: lysyl oxidase-like 2; lysyl oxidase-like protein 3; lysyl oxidase-related protein 2

NP_038614.2

EC 1.4.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013586.5 → NP_038614.2 lysyl oxidase homolog 3 precursor

See identical proteins and their annotated locations for NP_038614.2

Status: VALIDATED

Source sequence(s)

AC104324

Consensus CDS

CCDS20266.1

UniProtKB/Swiss-Prot

Q91VN8, Q9Z175

Related

ENSMUSP00000000707.3, ENSMUST00000000707.9

Conserved Domains (3) summary

smart00202
Location:308 → 408

SR; Scavenger receptor Cys-rich

pfam00530
Location:54 → 146

SRCR; Scavenger receptor cysteine-rich domain

pfam01186
Location:531 → 725

Lysyl_oxidase; Lysyl oxidase