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    Cops4 COP9 signalosome subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 26891, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cops4provided by MGI
    Official Full Name
    COP9 signalosome subunit 4provided by MGI
    Primary source
    MGI:MGI:1349414
    See related
    Ensembl:ENSMUSG00000035297 AllianceGenome:MGI:1349414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGN4; D5Ertd774e
    Summary
    Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in central nervous system; male reproductive system; and urinary system. Orthologous to human COPS4 (COP9 signalosome subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 42.5), placenta adult (RPKM 24.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cops4 in Genome Data Viewer
    Location:
    5 E4; 5 48.49 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100666223..100695668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100518295..100547802)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene STARR-seq mESC enhancer starr_13725 Neighboring gene STARR-seq mESC enhancer starr_13727 Neighboring gene STARR-positive B cell enhancer ABC_E2163 Neighboring gene predicted gene, 19620 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:100998499-100998608 Neighboring gene placenta-specific 8 Neighboring gene STARR-positive B cell enhancer ABC_E11295 Neighboring gene STARR-positive B cell enhancer ABC_E11296 Neighboring gene STARR-positive B cell enhancer mm9_chr5:101027025-101027325 Neighboring gene STARR-positive B cell enhancer ABC_E9256 Neighboring gene coenzyme Q2 4-hydroxybenzoate polyprenyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein. Liang E, et al. Neuropsychiatr Dis Treat, 2021. PMID 33911869, Free PMC Article
    2. Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes. Rockel B, et al. Biochem Biophys Res Commun, 2014 Jul 25. PMID 24973710
    3. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. Tomoda K, et al. J Biol Chem, 2002 Jan 18. PMID 11704659
    4. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. Pick E, et al. PLoS One, 2012. PMID 22956996, Free PMC Article
    5. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Deng XW, et al. Trends Genet, 2000 May. PMID 10782111

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151177, MGC151203

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deneddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 4
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 4
    COP9 (constitutive photomorphogenic), subunit 4
    COP9 complex S4
    JAB1-containing signalosome subunit 4
    signalosome subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359203.2 → NP_001346132.1  COP9 signalosome complex subunit 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC109196
      UniProtKB/TrEMBL
      Q3TIJ1
      Conserved Domains (3) summary
      COG5071
      Location:20 → 326
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam18420
      Location:314 → 355
      CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
      pfam01399
      Location:213 → 311
      PCI; PCI domain

    2. NM_001359204.2 → NP_001346133.1  COP9 signalosome complex subunit 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC109196
      UniProtKB/TrEMBL
      Q3TIJ1
      Conserved Domains (3) summary
      COG5071
      Location:20 → 326
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam18420
      Location:314 → 355
      CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
      pfam01399
      Location:213 → 311
      PCI; PCI domain

    3. NM_001425473.1 → NP_001412402.1  COP9 signalosome complex subunit 4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC109196

    4. NM_001425474.1 → NP_001412403.1  COP9 signalosome complex subunit 4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC109196

    5. NM_012001.3 → NP_036131.1  COP9 signalosome complex subunit 4 isoform a

      See identical proteins and their annotated locations for NP_036131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC109196
      Consensus CDS
      CCDS19463.1
      UniProtKB/Swiss-Prot
      O88544
      UniProtKB/TrEMBL
      Q14AI7, Q3TIJ1
      Related
      ENSMUSP00000048416.9, ENSMUST00000045993.15
      Conserved Domains (3) summary
      COG5071
      Location:71 → 377
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam18420
      Location:365 → 406
      CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
      pfam01399
      Location:264 → 362
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100666223..100695668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165149.1 → XP_036021042.1  COP9 signalosome complex subunit 4 isoform X3

      UniProtKB/TrEMBL
      D3YV99
      Related
      ENSMUSP00000114585.2, ENSMUST00000151414.8
      Conserved Domains (2) summary
      COG5071
      Location:20 → 170
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam18420
      Location:247 → 288
      CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain

    2. XM_006534953.4 → XP_006535016.1  COP9 signalosome complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006535016.1

      UniProtKB/TrEMBL
      Q3TIJ1
      Conserved Domains (3) summary
      COG5071
      Location:20 → 326
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam18420
      Location:314 → 355
      CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
      pfam01399
      Location:213 → 311
      PCI; PCI domain

    3. XM_036165147.1 → XP_036021040.1  COP9 signalosome complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      Q3TIJ1
      Conserved Domains (3) summary
      COG5071
      Location:20 → 326
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam18420
      Location:314 → 355
      CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
      pfam01399
      Location:213 → 311
      PCI; PCI domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88544.1 GenPept UniProtKB/Swiss-Prot:O88544

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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