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    Dcun1d1 defective in cullin neddylation 1 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 114893, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dcun1d1provided by MGI
    Official Full Name
    defective in cullin neddylation 1 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2150386
    See related
    Ensembl:ENSMUSG00000027708 AllianceGenome:MGI:2150386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rp42; Tes3; DCNL1; SCCRO; pTes3
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; protein neddylation; and regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human DCUN1D1 (defective in cullin neddylation 1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 11.9), liver E14 (RPKM 6.9) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dcun1d1 in Genome Data Viewer
    Location:
    3 B; 3 17.41 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (35946254..35991626, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (35892105..35937472, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene predicted gene 15952 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) Neighboring gene STARR-positive B cell enhancer ABC_E650 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 1 (alpha), opposite strand Neighboring gene gene model 57858

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cullin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DCN1-like protein 1
    Names
    DCN1, defective in cullin neddylation 1, domain containing 1
    DCUN1 domain-containing protein 1
    defective in cullin neddylation protein 1-like protein 1
    squamous cell carcinoma-related oncogene
    testis derived transcript 3
    testis-specific protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205361.1NP_001192290.1  DCN1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001192290.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116677, AK008657
      Consensus CDS
      CCDS57207.1
      UniProtKB/Swiss-Prot
      Q3TMX2, Q8CDZ7, Q9QZ73
      UniProtKB/TrEMBL
      Q3TMV8
      Related
      ENSMUSP00000103817.6, ENSMUST00000108182.10
      Conserved Domains (2) summary
      cd14411
      Location:151
      UBA_DCNL1; UBA-like domain found in DCN1-like protein 1 (DCNL1) and similar proteins
      pfam03556
      Location:136246
      Cullin_binding; Cullin binding
    2. NM_001205362.1NP_001192291.1  DCN1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001192291.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC116677
      Consensus CDS
      CCDS17306.1
      UniProtKB/TrEMBL
      Q3TMV8, Q3UT23
      Related
      ENSMUSP00000137324.2, ENSMUST00000178098.8
      Conserved Domains (2) summary
      pfam03556
      Location:121231
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    3. NM_033623.6NP_296372.3  DCN1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_296372.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC116677, AK139845
      Consensus CDS
      CCDS17306.1
      UniProtKB/TrEMBL
      Q3TMV8, Q3UT23
      Related
      ENSMUSP00000143243.2, ENSMUST00000198389.5
      Conserved Domains (2) summary
      pfam03556
      Location:121231
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      35946254..35991626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535374.4XP_006535437.1  DCN1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006535437.1

      UniProtKB/TrEMBL
      Q3TMV8, Q3UT23
      Related
      ENSMUSP00000115420.4, ENSMUST00000148465.8
      Conserved Domains (2) summary
      pfam03556
      Location:121231
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    2. XM_036162862.1XP_036018755.1  DCN1-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam03556
      Location:136173
      Cullin_binding; Cullin binding
      cl21463
      Location:151
      UBA_like_SF; UBA domain-like superfamily

    RNA

    1. XR_003954274.2 RNA Sequence