Pold4 polymerase (DNA-directed), delta 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pold4provided by MGI
Official Full Name: polymerase (DNA-directed), delta 4provided by MGI
Primary source: MGI:MGI:1916995
See related: Ensembl:ENSMUSG00000024854 AllianceGenome:MGI:1916995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p12; Polds; 2410012M21Rik
Summary: Predicted to contribute to DNA-directed DNA polymerase activity. Acts upstream of or within positive regulation of endothelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; cranium; genitourinary system; liver; and respiratory system. Orthologous to human POLD4 (DNA polymerase delta 4, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 98.4), mammary gland adult (RPKM 59.5) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19 A; 19 3.93 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4281947..4283688)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4231893..4233634)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pold4 is dispensable for mouse development, DNA replication and DNA repair.
Title: Pold4 is dispensable for mouse development, DNA replication and DNA repair.
The identification of RNF8 allows new insights into the integration of the control of p12 degradation by different DNA damage signaling pathways.
Title: Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

Go to the top of the page Help

Markers

AI463381 (e-PCR)
- UniSTS:160782

AW743072 (e-PCR)
- UniSTS:209431

NoName (e-PCR)
- UniSTS:237866

Readthrough Gm45928

Readthrough gene: Gm45928, Included gene: Clcf1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA synthesis involved in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA synthesis involved in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of delta DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of delta DNA polymerase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: DNA polymerase delta subunit 4

Names: DNA polymerase delta smallest subunit p12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027196.4 → NP_081472.1 DNA polymerase delta subunit 4

See identical proteins and their annotated locations for NP_081472.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

AC140073, BC028520

Consensus CDS

CCDS29424.1

UniProtKB/Swiss-Prot

Q9CWP8

UniProtKB/TrEMBL

A0A494BBE1, Q547B4

Related

ENSMUSP00000025773.4, ENSMUST00000025773.5

Conserved Domains (1) summary

pfam04081
Location:49 → 88

DNA_pol_delta_4; DNA polymerase delta, subunit 4

RNA

NR_132280.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and retains a portion of intron in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.

Source sequence(s)

AC140073, BC028520, BQ561369

Related

ENSMUST00000235306.2