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    Dnase1 deoxyribonuclease I [ Mus musculus (house mouse) ]

    Gene ID: 13419, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnase1provided by MGI
    Official Full Name
    deoxyribonuclease Iprovided by MGI
    Primary source
    MGI:MGI:103157
    See related
    Ensembl:ENSMUSG00000005980 AllianceGenome:MGI:103157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnl1; DNaseI
    Summary
    Enables deoxyribonuclease I activity. Involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in extracellular region; nuclear envelope; and zymogen granule. Predicted to be active in nucleus. Is expressed in jejunum; metanephros; and tongue. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 666.1), duodenum adult (RPKM 123.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnase1 in Genome Data Viewer
    Location:
    16 A1; 16 2.37 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3855007..3857888)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4036958..4040024)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene NLR family, CARD domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3976439-3976665 Neighboring gene STARR-seq mESC enhancer starr_39914 Neighboring gene SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) Neighboring gene TNF receptor-associated protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4077725-4077912 Neighboring gene CREB binding protein Neighboring gene STARR-seq mESC enhancer starr_39921 Neighboring gene RIKEN cDNA 4930455F16 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease. Kenny EF, et al. Eur J Immunol, 2019 Apr. PMID 30758851
    2. Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice. Fenton K, et al. PLoS One, 2009 Dec 29. PMID 20041189, Free PMC Article
    3. Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis. Seredkina N, et al. Am J Pathol, 2011 Sep. PMID 21723244, Free PMC Article
    4. Progression of murine lupus nephritis is linked to acquired renal Dnase1 deficiency and not to up-regulated apoptosis. Seredkina N, et al. Am J Pathol, 2009 Jul. PMID 19528352, Free PMC Article
    5. Inhibition of deoxyribonuclease I by actin is to protect cells from premature cell death. Eulitz D, et al. Apoptosis, 2007 Aug. PMID 17468836

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.
      Title: A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.
    2. The protective effect of DNase I in retinal vein occlusion.
      Title: The protective effect of DNase I in retinal vein occlusion.
    3. Targeting NETs using dual-active DNase1 variants.
      Title: Targeting NETs using dual-active DNase1 variants.
    4. Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
      Title: Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
    5. Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris.
      Title: Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris.
    6. this model recapitulates the female bias seen in human SLE patients since female Dnase1-deficient mice produced the highest concentrations of autoantibodies and had more severe kidney damage than males.
      Title: Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.
    7. DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps.
      Title: Host DNases prevent vascular occlusion by neutrophil extracellular traps.
    8. HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.
      Title: HMGN1 modulates nucleosome occupancy and DNase I hypersensitivity at the CpG island promoters of embryonic stem cells.
    9. Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI by transcriptional interference.
      Title: Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis.
    10. silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis
      Title: Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144446, MGC144447

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease I activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables deoxyribonuclease I activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of acute inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neutrophil mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in zymogen granule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deoxyribonuclease-1
    NP_001344072.1
    NP_001403712.1
    NP_001403713.1
    NP_034191.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357143.2 → NP_001344072.1  deoxyribonuclease-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC087900
      Consensus CDS
      CCDS27913.1
      UniProtKB/Swiss-Prot
      O70532, P49183
      UniProtKB/TrEMBL
      Q14BW6, Q14BW7, Q91WL7
      Related
      ENSMUSP00000113119.2, ENSMUST00000120009.8
      Conserved Domains (1) summary
      smart00476
      Location:20 → 282
      DNaseIc; deoxyribonuclease I

    2. NM_001416783.1 → NP_001403712.1  deoxyribonuclease-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC087900
      UniProtKB/Swiss-Prot
      O70532, P49183
      UniProtKB/TrEMBL
      Q14BW6

    3. NM_001416784.1 → NP_001403713.1  deoxyribonuclease-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC087900
      UniProtKB/Swiss-Prot
      O70532, P49183
      UniProtKB/TrEMBL
      Q14BW6
      Related
      ENSMUST00000125961.8

    4. NM_010061.6 → NP_034191.3  deoxyribonuclease-1 precursor

      See identical proteins and their annotated locations for NP_034191.3

      Status: VALIDATED

      Source sequence(s)
      AC087900
      Consensus CDS
      CCDS27913.1
      UniProtKB/Swiss-Prot
      O70532, P49183
      UniProtKB/TrEMBL
      Q14BW6, Q14BW7, Q91WL7
      Related
      ENSMUSP00000006136.5, ENSMUST00000006136.11
      Conserved Domains (1) summary
      smart00476
      Location:20 → 282
      DNaseIc; deoxyribonuclease I

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3855007..3857888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49183.2 GenPept UniProtKB/Swiss-Prot:P49183

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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