Rnf185 ring finger protein 185 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf185provided by MGI
Official Full Name: ring finger protein 185provided by MGI
Primary source: MGI:MGI:1922078
See related: Ensembl:ENSMUSG00000020448 AllianceGenome:MGI:1922078
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in several processes, including positive regulation of ERAD pathway; protein ubiquitination; and proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum. Is expressed in central nervous system; genitourinary system; and olfactory epithelium. Orthologous to human RNF185 (ring finger protein 185). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 16.3), kidney adult (RPKM 15.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.4 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (3365973..3402956, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (3415973..3452956, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential.
Title: RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like protein conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein conjugating enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K27-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K27-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF185

Names: RING-type E3 ubiquitin transferase RNF185

NP_001277401.1

EC 2.3.2.27

NP_001277402.1

EC 2.3.2.27

NP_663330.2

EC 2.3.2.27

XP_006514657.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290472.1 → NP_001277401.1 E3 ubiquitin-protein ligase RNF185 isoform 2

See identical proteins and their annotated locations for NP_001277401.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK034108, AK075756, AL713875, AV347010

Consensus CDS

CCDS70127.1

UniProtKB/Swiss-Prot

Q6ZWS3, Q91YT2

Related

ENSMUSP00000076333.6, ENSMUST00000077078.12

Conserved Domains (1) summary

cd00162
Location:38 → 83

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001290473.1 → NP_001277402.1 E3 ubiquitin-protein ligase RNF185 isoform 3

See identical proteins and their annotated locations for NP_001277402.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK034108, AK075756, AL713875, AV347010

UniProtKB/Swiss-Prot

Q91YT2

Conserved Domains (2) summary

PLN03208
Location:29 → 65

PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional

cl17238
Location:8 → 33

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_145355.5 → NP_663330.2 E3 ubiquitin-protein ligase RNF185 isoform 1

See identical proteins and their annotated locations for NP_663330.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK034108, AK075756, AL713875, AV347010

Consensus CDS

CCDS24361.1

UniProtKB/Swiss-Prot

Q91YT2

Related

ENSMUSP00000067053.3, ENSMUST00000064364.3

Conserved Domains (1) summary

cd00162
Location:74 → 119

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

NR_110959.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK034108, AK075756, AL713875, AV347010

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

3365973..3402956 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514594.5 → XP_006514657.1 E3 ubiquitin-protein ligase RNF185 isoform X1

See identical proteins and their annotated locations for XP_006514657.1

Conserved Domains (2) summary

PLN03208
Location:29 → 65

PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional

cl17238
Location:8 → 33

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain