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    C1qtnf1 C1q and tumor necrosis factor related protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56745, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C1qtnf1provided by MGI
    Official Full Name
    C1q and tumor necrosis factor related protein 1provided by MGI
    Primary source
    MGI:MGI:1919254
    See related
    Ensembl:ENSMUSG00000017446 AllianceGenome:MGI:1919254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adip; CTRP1; Zsig37; 1600017K21Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of glucose metabolic process. Located in extracellular space. Is expressed in axial skeleton; cerebral cortex; heart; tooth; and vibrissa. Orthologous to human C1QTNF1 (C1q and TNF related 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 21.5), subcutaneous fat pad adult (RPKM 17.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1qtnf1 in Genome Data Viewer
    Location:
    11 E2; 11 83.17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118319187..118342608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118428457..118451782)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium activated nucleotidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E5311 Neighboring gene predicted gene, 35598 Neighboring gene predicted gene 11747 Neighboring gene STARR-seq mESC enhancer starr_31303 Neighboring gene STARR-positive B cell enhancer ABC_E3042 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene endo-beta-N-acetylglucosaminidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition. Peterson JM, et al. J Biol Chem, 2012 Jan 6. PMID 22086915, Free PMC Article
    2. A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway. Akiyama H, et al. Mol Cell Endocrinol, 2013 Apr 30. PMID 23348620
    3. CTRP1 protects against diet-induced hyperglycemia by enhancing glycolysis and fatty acid oxidation. Han S, et al. J Nutr Biochem, 2016 Jan. PMID 26456564
    4. Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice. Rodriguez S, et al. Am J Physiol Regul Integr Comp Physiol, 2021 Jan 1. PMID 33085906, Free PMC Article
    5. C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart. Yuasa D, et al. FASEB J, 2016 Mar. PMID 26578687

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1.
      Title: ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1.
    2. CTRP1 Aggravates Cardiac Dysfunction Post Myocardial Infarction by Modulating TLR4 in Macrophages.
      Title: CTRP1 Aggravates Cardiac Dysfunction Post Myocardial Infarction by Modulating TLR4 in Macrophages.
    3. CTRP1 prevents sepsis-induced cardiomyopathy via Sirt1-dependent pathways.
      Title: CTRP1 prevents sepsis-induced cardiomyopathy via Sirt1-dependent pathways.
    4. Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.
      Title: Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.
    5. Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1.
      Title: Late-onset renal hypertrophy and dysfunction in mice lacking CTRP1.
    6. CTRP1 contributes to the regulation of blood pressure homeostasis by preventing dehydration-induced hypotension.
      Title: C1q/TNF-α-Related Protein 1 (CTRP1) Maintains Blood Pressure Under Dehydration Conditions.
    7. C1QTNF1 deficiency accelerates cardiac hypertrophy and fibrosis through decreasing AMPKa pathway.
      Title: C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway.
    8. CTRP1 protected against Dox-induced cardiotoxicity via activation of AKT
      Title: C1qTNF-related protein 1 attenuates doxorubicin-induced cardiac injury via activation of AKT.
    9. CTRP1 functions to prevent the development of pathological vascular remodeling by reducing vascular smooth muscle cell growth and neointima formation through cAMP-dependent pathway.
      Title: C1q/TNF-related protein 1 prevents neointimal formation after arterial injury.
    10. By using en face staining of mouse aorta, the study found CTRP1 expression was significantly increased in vascular endothelial cells under disturbed flow as compared to steady laminar flow.
      Title: C1q/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of aldosterone secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of aldosterone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 1
    Names
    adiponectin p
    putative secreted protein ZSIG37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204129.1 → NP_001191058.1  complement C1q tumor necrosis factor-related protein 1 precursor

      See identical proteins and their annotated locations for NP_001191058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK005484, AL591075, BM934297
      Consensus CDS
      CCDS25703.1
      UniProtKB/Swiss-Prot
      Q80VI9, Q9QXP7
      UniProtKB/TrEMBL
      A0A3B0J1J8
      Related
      ENSMUSP00000017590.3, ENSMUST00000017590.9
      Conserved Domains (2) summary
      pfam01391
      Location:98 → 138
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:147 → 275
      C1q; C1q domain

    2. NM_001204130.1 → NP_001191059.1  complement C1q tumor necrosis factor-related protein 1 precursor

      See identical proteins and their annotated locations for NP_001191059.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL591075
      Consensus CDS
      CCDS25703.1
      UniProtKB/Swiss-Prot
      Q80VI9, Q9QXP7
      UniProtKB/TrEMBL
      A0A3B0J1J8
      Conserved Domains (2) summary
      pfam01391
      Location:98 → 138
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:147 → 275
      C1q; C1q domain

    3. NM_019959.3 → NP_064343.1  complement C1q tumor necrosis factor-related protein 1 precursor

      See identical proteins and their annotated locations for NP_064343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL591075, CJ056741
      Consensus CDS
      CCDS25703.1
      UniProtKB/Swiss-Prot
      Q80VI9, Q9QXP7
      UniProtKB/TrEMBL
      A0A3B0J1J8
      Related
      ENSMUSP00000101893.2, ENSMUST00000106286.3
      Conserved Domains (2) summary
      pfam01391
      Location:98 → 138
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:147 → 275
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      118319187..118342608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156867.1 → XP_036012760.1  complement C1q tumor necrosis factor-related protein 1 isoform X1

      Conserved Domains (2) summary
      pfam00386
      Location:167 → 295
      C1q; C1q domain
      pfam01391
      Location:118 → 158
      Collagen; Collagen triple helix repeat (20 copies)

    2. XM_006533821.4 → XP_006533884.1  complement C1q tumor necrosis factor-related protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006533884.1

      UniProtKB/Swiss-Prot
      Q80VI9, Q9QXP7
      UniProtKB/TrEMBL
      A0A3B0J1J8
      Conserved Domains (2) summary
      pfam01391
      Location:98 → 138
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:147 → 275
      C1q; C1q domain

    3. XM_006533822.5 → XP_006533885.1  complement C1q tumor necrosis factor-related protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006533885.1

      UniProtKB/Swiss-Prot
      Q80VI9, Q9QXP7
      UniProtKB/TrEMBL
      A0A3B0J1J8
      Conserved Domains (2) summary
      pfam01391
      Location:98 → 138
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:147 → 275
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXP7.1 GenPept UniProtKB/Swiss-Prot:Q9QXP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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