Unc45b unc-45 myosin chaperone B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Unc45bprovided by MGI
Official Full Name: unc-45 myosin chaperone Bprovided by MGI
Primary source: MGI:MGI:2443377
See related: Ensembl:ENSMUSG00000018845 AllianceGenome:MGI:2443377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cmya4; Unc45; UNC-45B; D230041A13Rik
Summary: Enables Hsp90 protein binding activity. Acts upstream of or within chaperone-mediated protein folding. Located in cytosol. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and soleus. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to human UNC45B (unc-45 myosin chaperone B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 41.6), mammary gland adult (RPKM 6.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 50.3 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (82802112..82834284)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (82911253..82943406)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-45B and Hsp90 involved in sarcomere function
Title: Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.
mammalian Unc45b is a cytosolic protein that forms a stable complex with Hsp90, selectively binds the unfolded conformation of the myosin motor domain, and promotes motor domain folding
Title: Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain.
vertebrate Unc45 isoforms clearly demonstrates a direct role for Unc45 in Hsp90-mediated myosin motor domain folding and highlights major differences between the isoforms in substrate specificity and mechanism
Title: Unc45 activates Hsp90-dependent folding of the myosin motor domain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA445617 (e-PCR), detects polymorphism
- UniSTS:259403

Unc45b (e-PCR), detects polymorphism
- UniSTS:259446

D230041A13Rik (e-PCR), detects polymorphism
- UniSTS:259447

D11Pas71 (e-PCR), detects polymorphism
- UniSTS:259489

D11Pas77 (e-PCR), detects polymorphism
- UniSTS:259495

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in lens development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in A band	IEA Inferred from Electronic Annotation more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein unc-45 homolog B

Names: cardiomyopathy associated 4; striated muscle UNC45; unc-45 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415076.1 → NP_001402005.1 protein unc-45 homolog B isoform 2

Status: VALIDATED

Source sequence(s)

AL603745
NM_178680.5 → NP_848795.3 protein unc-45 homolog B isoform 1

See identical proteins and their annotated locations for NP_848795.3

Status: VALIDATED

Source sequence(s)

AL603745

Consensus CDS

CCDS36251.1

UniProtKB/Swiss-Prot

Q5XG72, Q8BHC5, Q8BWK3, Q8CGY6

Related

ENSMUSP00000018989.8, ENSMUST00000018989.14

Conserved Domains (5) summary

cd00020
Location:716 → 831

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00006
Location:6 → 34

TPR; TPR repeat [structural motif]

pfam11701
Location:344 → 489

UNC45-central; Myosin-binding striated muscle assembly central

pfam13414
Location:5 → 73

TPR_11; TPR repeat

sd00043
Location:752 → 786

ARM; armadillo repeat [structural motif]