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    ZNF512B zinc finger protein 512B [ Homo sapiens (human) ]

    Gene ID: 57473, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF512Bprovided by HGNC
    Official Full Name
    zinc finger protein 512Bprovided by HGNC
    Primary source
    HGNC:HGNC:29212
    See related
    Ensembl:ENSG00000196700 MIM:617886; AllianceGenome:HGNC:29212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GM632
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of miRNA transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 5.4), thyroid (RPKM 5.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF512B in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63956704..63969930, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65777665..65789614, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62588057..62601283, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62573671-62574384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62574385-62575096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18255 Neighboring gene microRNA 1914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580108-62580646 Neighboring gene uridine-cytidine kinase 1 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580647-62581185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62581186-62581724 Neighboring gene microRNA 647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62587955-62588842 Neighboring gene UCKL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62588843-62589728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62599635-62600172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62600173-62600708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13196 Neighboring gene Sharpr-MPRA regulatory region 2003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62610429-62610944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13198 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene pre-mRNA processing factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62631004-62631506 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62636447-62636619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62642795-62643994 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:62648052-62649251

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (31 hits/1283 screens)

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 512B (ZNF512B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • KIAA1196, MGC149845, MGC149846

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleoplasm  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020713.3NP_065764.1  zinc finger protein 512B

      See identical proteins and their annotated locations for NP_065764.1

      Status: VALIDATED

      Source sequence(s)
      AL118506, AL834525, AW453003, BC125128, BC125129
      Consensus CDS
      CCDS13548.1
      UniProtKB/Swiss-Prot
      Q08AK9, Q96KM6, Q9ULM4
      Related
      ENSP00000358904.1, ENST00000369888.6
      Conserved Domains (2) summary
      sd00017
      Location:596617
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26386
      Location:223448
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      63956704..63969930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440326.1XP_047296282.1  zinc finger protein 512B isoform X1

    2. XM_047440327.1XP_047296283.1  zinc finger protein 512B isoform X2

      UniProtKB/Swiss-Prot
      Q08AK9, Q96KM6, Q9ULM4
    3. XM_011528930.3XP_011527232.1  zinc finger protein 512B isoform X3

      Conserved Domains (3) summary
      PRK12323
      Location:237462
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      sd00017
      Location:610631
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:526555
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_047440328.1XP_047296284.1  zinc finger protein 512B isoform X4

    5. XM_047440329.1XP_047296285.1  zinc finger protein 512B isoform X5

    6. XM_011528933.3XP_011527235.1  zinc finger protein 512B isoform X6

      Conserved Domains (2) summary
      PTZ00249
      Location:294430
      PTZ00249; variable surface protein Vir28; Provisional
      PRK14950
      Location:236308
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65777665..65789614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323767.1XP_054179742.1  zinc finger protein 512B isoform X1

    2. XM_054323768.1XP_054179743.1  zinc finger protein 512B isoform X2

      UniProtKB/Swiss-Prot
      Q08AK9, Q96KM6, Q9ULM4
    3. XM_054323769.1XP_054179744.1  zinc finger protein 512B isoform X3

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