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    ADCYAP1 adenylate cyclase activating polypeptide 1 [ Homo sapiens (human) ]

    Gene ID: 116, updated on 10-Dec-2024

    Summary

    Official Symbol
    ADCYAP1provided by HGNC
    Official Full Name
    adenylate cyclase activating polypeptide 1provided by HGNC
    Primary source
    HGNC:HGNC:241
    See related
    Ensembl:ENSG00000141433 MIM:102980; AllianceGenome:HGNC:241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PACAP
    Summary
    This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
    Expression
    Biased expression in appendix (RPKM 6.6), brain (RPKM 5.7) and 11 other tissues See more
    Orthologs
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    Genomic context

    See ADCYAP1 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (904411..912172)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (1058628..1066467)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (904872..912173)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene Neighboring gene MPRA-validated peak3036 silencer Neighboring gene uncharacterized LOC124904340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:907717-908438 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:909161-909882 Neighboring gene long intergenic non-protein coding RNA 1904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:949337-949911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:949912-950485 Neighboring gene uncharacterized LOC107985165 Neighboring gene Sharpr-MPRA regulatory region 14540 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:1011056-1012255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:1015112-1015673

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (12 hits/1249 screens)

    EBI GWAS Catalog

    Description
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat PACAP27-induced release of CCL5 inhibits HIV-1 Tat-mediated toxicity in human astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC126852

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in activation of adenylate cyclase activity PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway PubMed 
    involved_in cell-cell signaling PubMed 
    involved_in female pregnancy PubMed 
    involved_in insulin secretion  
    involved_in negative regulation of cell cycle  
    involved_in neuron projection development  
    involved_in neuron projection development PubMed 
    involved_in neuropeptide signaling pathway  
    involved_in neuropeptide signaling pathway PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of GTPase activity PubMed 
    involved_in positive regulation of chemokine (C-C motif) ligand 5 production PubMed 
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of growth hormone secretion  
    involved_in positive regulation of protein kinase activity PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway PubMed 
    involved_in regulation of protein localization  
    involved_in regulation of protein localization PubMed 
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space PubMed 
    is_active_in neuron projection  
    is_active_in perikaryon  

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide
    Names
    adenylate cyclase activating polypeptide 1 (pituitary)
    prepro-PACAP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099733.2 → NP_001093203.1  pituitary adenylate cyclase-activating polypeptide preproprotein

      See identical proteins and their annotated locations for NP_001093203.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AP000894, BC093837, DC320719
      Consensus CDS
      CCDS11825.1
      UniProtKB/Swiss-Prot
      B2R7N4, P18509, Q52LQ0
      Related
      ENSP00000411658.3, ENST00000450565.8
      Conserved Domains (2) summary
      smart00070
      Location:83 → 109
      GLUCA; Glucagon like hormones
      pfam00123
      Location:132 → 158
      Hormone_2; Peptide hormone
    2. NM_001117.5 → NP_001108.2  pituitary adenylate cyclase-activating polypeptide preproprotein

      See identical proteins and their annotated locations for NP_001108.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AP000894, BC093837
      Consensus CDS
      CCDS11825.1
      UniProtKB/Swiss-Prot
      B2R7N4, P18509, Q52LQ0
      Related
      ENSP00000462647.1, ENST00000579794.1
      Conserved Domains (2) summary
      smart00070
      Location:83 → 109
      GLUCA; Glucagon like hormones
      pfam00123
      Location:132 → 158
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      904411..912172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258081.5 → XP_005258138.2  pituitary adenylate cyclase-activating polypeptide isoform X2

      UniProtKB/TrEMBL
      B7Z222
      Conserved Domains (2) summary
      smart00070
      Location:222 → 248
      GLUCA; Glucagon like hormones
      pfam00123
      Location:271 → 297
      Hormone_2; Peptide hormone
    2. XM_047437288.1 → XP_047293244.1  pituitary adenylate cyclase-activating polypeptide isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      1058628..1066467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318174.1 → XP_054174149.1  pituitary adenylate cyclase-activating polypeptide isoform X3

    2. XM_054318173.1 → XP_054174148.1  pituitary adenylate cyclase-activating polypeptide isoform X1

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