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    SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 [ Homo sapiens (human) ]

    Gene ID: 84727, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPSB2provided by HGNC
    Official Full Name
    splA/ryanodine receptor domain and SOCS box containing 2provided by HGNC
    Primary source
    HGNC:HGNC:29522
    See related
    Ensembl:ENSG00000111671 MIM:611658; AllianceGenome:HGNC:29522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSB2; GRCC9
    Summary
    This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in brain (RPKM 50.3), appendix (RPKM 44.2) and 19 other tissues See more
    Orthologs
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    Genomic context

    See SPSB2 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6870935..6873303, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6880233..6882601, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6980099..6982467, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6960952-6961912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4186 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6974948-6975610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6975611-6976272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6979885-6980470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5888 Neighboring gene triosephosphate isomerase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4190 Neighboring gene uncharacterized LOC105369632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6992574-6993122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6993123-6993671 Neighboring gene ribosomal protein L13 pseudogene 5 Neighboring gene DSTN pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC2519, FLJ17395

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    located_in cytosol PubMed 
    located_in cytosol  

    General protein information

    Preferred Names
    SPRY domain-containing SOCS box protein 2
    Names
    SPRY domain-containing SOCS box protein SSB-2
    gene-rich cluster protein C9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013308.1 RefSeqGene

      Range
      5055..7423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001146316.2 → NP_001139788.1  SPRY domain-containing SOCS box protein 2

      See identical proteins and their annotated locations for NP_001139788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein.
      Source sequence(s)
      BC071933, U47924
      Consensus CDS
      CCDS8567.1
      UniProtKB/Swiss-Prot
      B7Z4W1, D3DUT0, Q99619
      Related
      ENSP00000430872.1, ENST00000523102.5
      Conserved Domains (2) summary
      cd03719
      Location:222 → 263
      SOCS_SSB2; SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:46 → 217
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    2. NM_001319670.2 → NP_001306599.1  SPRY domain-containing SOCS box protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate segment in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein.
      Source sequence(s)
      U47924
      Consensus CDS
      CCDS8567.1
      UniProtKB/Swiss-Prot
      B7Z4W1, D3DUT0, Q99619
      Conserved Domains (2) summary
      cd03719
      Location:222 → 263
      SOCS_SSB2; SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:46 → 217
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    3. NM_032641.4 → NP_116030.1  SPRY domain-containing SOCS box protein 2

      See identical proteins and their annotated locations for NP_116030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the reference variant. Variants 1, 2, and 4 encode the same protein.
      Source sequence(s)
      BC002983, DT220163
      Consensus CDS
      CCDS8567.1
      UniProtKB/Swiss-Prot
      B7Z4W1, D3DUT0, Q99619
      Related
      ENSP00000428338.1, ENST00000524270.6
      Conserved Domains (2) summary
      cd03719
      Location:222 → 263
      SOCS_SSB2; SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for ...
      cd12906
      Location:46 → 217
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      6870935..6873303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      6880233..6882601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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