SIRT3 sirtuin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SIRT3provided by HGNC
Official Full Name: sirtuin 3provided by HGNC
Primary source: HGNC:HGNC:14931
See related: Ensembl:ENSG00000142082 MIM:604481; AllianceGenome:HGNC:14931
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIR2L3
Summary: SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
Expression: Ubiquitous expression in testis (RPKM 6.7), brain (RPKM 5.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (215030..236931, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (256228..277937, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (215030..236931, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-beta1/smad2/3 signalling pathway.
Title: SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-β1/smad2/3 signalling pathway.
Quantitative analysis of the lysine acetylome reveals the role of SIRT3-mediated HSP60 deacetylation in suppressing intracellular Mycobacterium tuberculosis survival.
Title: Quantitative analysis of the lysine acetylome reveals the role of SIRT3-mediated HSP60 deacetylation in suppressing intracellular Mycobacterium tuberculosis survival.
SIRT3 suppression resulting from the enhanced beta-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells.
Title: SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells.
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
Title: Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes.
Title: SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes.
Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus.
Title: Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus.
The protective mechanism of SIRT3 and potential therapy in acute kidney injury.
Title: The protective mechanism of SIRT3 and potential therapy in acute kidney injury.
Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.
Title: Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.
Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.
Title: Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.
Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11.
Title: Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11.

Submit: New GeneRIF Correction See all GeneRIFs (327)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH15952 (e-PCR)
- UniSTS:46868

G19667 (e-PCR)
- UniSTS:59448

A001U35 (e-PCR)
- UniSTS:59449

A004P12 (e-PCR)
- UniSTS:55647

WI-19967 (e-PCR)
- UniSTS:54372

D11S3074 (e-PCR)
- UniSTS:152171

SIRT3_3197.2 (e-PCR)
- UniSTS:468129

RH78086 (e-PCR)
- UniSTS:19111

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables NAD+-protein ADP-ribosyltransferase activity	TAS Traceable Author Statement more info	PubMed
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein lysine deacetylase activity	TAS Traceable Author Statement more info
enables NAD-dependent protein lysine delactylase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of catalase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ceramide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Names: NAD-dependent deacetylase sirtuin-3, mitochondrial; NAD-dependent protein delactylase sirtuin-3; SIR2-like protein 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; regulatory protein SIR2 homolog 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; sirtuin type 3

NP_001017524.1

EC 2.3.1.286

NP_001357239.1

EC 2.3.1.286

NP_001357241.1

EC 2.3.1.286

NP_001357243.1

EC 2.3.1.286

NP_001357244.1

EC 2.3.1.286

NP_001357245.1

EC 2.3.1.286

NP_001357246.1

EC 2.3.1.286

NP_001357247.1

EC 2.3.1.286

NP_001357248.1

EC 2.3.1.286

NP_001357249.1

EC 2.3.1.286

NP_001357250.1

EC 2.3.1.286

NP_001357251.1

EC 2.3.1.286

NP_001357252.1

EC 2.3.1.286

NP_001357253.1

EC 2.3.1.286

NP_001357254.1

EC 2.3.1.286

NP_036371.1

EC 2.3.1.286

XP_011518258.1

EC 2.3.1.286

XP_011518259.1

EC 2.3.1.286

XP_016872920.1

EC 2.3.1.286

XP_047282633.1

EC 2.3.1.286

XP_054224211.1

EC 2.3.1.286

XP_054224212.1

EC 2.3.1.286

XP_054224213.1

EC 2.3.1.286

XP_054224214.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017524.3 → NP_001017524.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

See identical proteins and their annotated locations for NP_001017524.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' end which causes the use of a downstream start codon, compared to variant 1. The resulting protein (isoform b) is shorter at the N-terminus compared to isoform a. Variants 2 and 9-11 all encode the same isoform (b).

Source sequence(s)

AC069287, AI091200, AL535769, BC001042, BI755839, BM973763, DR762907

Consensus CDS

CCDS53590.1

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370310.1 → NP_001357239.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longest isoform (c).

Source sequence(s)

AC069287, AC136475

UniProtKB/TrEMBL

B7Z7G4

Conserved Domains (1) summary

cd01408
Location:138 → 373

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370312.1 → NP_001357241.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform d

Status: REVIEWED

Source sequence(s)

AC069287, AC136475, AK301558

Consensus CDS

CCDS91392.1

UniProtKB/TrEMBL

B7Z777, E9PN58

Related

ENSP00000432937.1, ENST00000524564.5

Conserved Domains (1) summary

cd01408
Location:88 → 309

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370314.1 → NP_001357243.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform e

Status: REVIEWED

Source sequence(s)

AC069287, AC136475, AK299009

Consensus CDS

CCDS91393.1

UniProtKB/TrEMBL

B7Z5J1, E9PM75

Related

ENSP00000433077.1, ENST00000532956.5

Conserved Domains (1) summary

cl00195
Location:138 → 319

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_001370315.1 → NP_001357244.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform f precursor

Status: REVIEWED

Source sequence(s)

AC069287, AC136475, AK298572

Consensus CDS

CCDS91394.1

UniProtKB/TrEMBL

B7Z580, E9PK80

Related

ENSP00000435464.1, ENST00000525319.5

Conserved Domains (1) summary

cd01408
Location:57 → 292

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370316.1 → NP_001357245.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform g precursor

Status: REVIEWED

Source sequence(s)

AC069287, AC136475

Conserved Domains (1) summary

cl00195
Location:46 → 149

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_001370317.1 → NP_001357246.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform h

Status: REVIEWED

Source sequence(s)

AC069287, AC136475, HY006161

Conserved Domains (1) summary

cl00195
Location:1 → 101

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_001370318.1 → NP_001357247.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 2, 10, and 11, encodes isoform b.

Source sequence(s)

AC069287, AC136475

Consensus CDS

CCDS53590.1

UniProtKB/TrEMBL

B7ZA60

Related

ENSP00000437216.1, ENST00000529382.5

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370319.1 → NP_001357248.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 2, 9, and 11, encodes isoform b.

Source sequence(s)

AC069287, AC136475

Consensus CDS

CCDS53590.1

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370320.1 → NP_001357249.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variants 2, 9, and 10, encodes isoform b.

Source sequence(s)

AC069287, AC136475

Consensus CDS

CCDS53590.1

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370321.1 → NP_001357250.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform i.

Source sequence(s)

AC069287, AC136475

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370322.1 → NP_001357251.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform i.

Source sequence(s)

AC069287, AC136475

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370323.1 → NP_001357252.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform i.

Source sequence(s)

AC069287, AC136475

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_001370324.1 → NP_001357253.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variant 16, encodes isoform j.

Source sequence(s)

AC069287, AC136475

Conserved Domains (1) summary

cl00195
Location:1 → 181

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_001370325.1 → NP_001357254.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (16), as well as variant 15, encodes isoform j.

Source sequence(s)

AC069287, AC136475

Conserved Domains (1) summary

cl00195
Location:1 → 181

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_012239.6 → NP_036371.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a

See identical proteins and their annotated locations for NP_036371.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AC069287, AI091200, AL535769, BC001042, BM973763, DR762907

Consensus CDS

CCDS7691.1

UniProtKB/Swiss-Prot

B7Z5U6, Q9NTG7, Q9Y6E8

UniProtKB/TrEMBL

B7Z7G4

Related

ENSP00000372191.4, ENST00000382743.9

Conserved Domains (1) summary

cd01408
Location:138 → 373

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RNA

NR_163386.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163387.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163388.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163389.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163390.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163391.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163392.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163393.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163394.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163395.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163396.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163397.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163398.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163399.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163400.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163401.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475
NR_163402.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC069287, AC136475

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

215030..236931 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426677.1 → XP_047282633.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

UniProtKB/TrEMBL

B7ZA60
XM_017017431.2 → XP_016872920.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
XM_011519957.3 → XP_011518259.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_011518259.1

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
XM_011519956.3 → XP_011518258.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_011518258.1

UniProtKB/TrEMBL

B7ZA60

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

RNA

XR_007062467.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

256228..277937 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054368239.1 → XP_054224214.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

UniProtKB/TrEMBL

B7ZA60
XM_054368238.1 → XP_054224213.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

UniProtKB/TrEMBL

B7ZA60
XM_054368236.1 → XP_054224211.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

UniProtKB/TrEMBL

B7ZA60
XM_054368237.1 → XP_054224212.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

UniProtKB/TrEMBL

B7ZA60