U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    WNT16 Wnt family member 16 [ Homo sapiens (human) ]

    Gene ID: 51384, updated on 10-Dec-2024

    Summary

    Official Symbol
    WNT16provided by HGNC
    Official Full Name
    Wnt family member 16provided by HGNC
    Primary source
    HGNC:HGNC:16267
    See related
    Ensembl:ENSG00000002745 MIM:606267; AllianceGenome:HGNC:16267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 9.9) and lymph node (RPKM 0.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WNT16 in Genome Data Viewer
    Location:
    7q31.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (121325367..121341104)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (122640682..122656420)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (120965421..120981158)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cadherin like and PC-esterase domain containing 1 Neighboring gene RNA, 5S ribosomal pseudogene 241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26557 Neighboring gene uncharacterized LOC124901735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26560 Neighboring gene RNA, U6 small nuclear 517, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:120931342-120931494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26562 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:121025354-121025551 Neighboring gene FAM3 metabolism regulating signaling molecule C Neighboring gene hESC enhancers GRCh37_chr7:121035399-121035984 and GRCh37_chr7:121035985-121036569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18576 Neighboring gene CYCS pseudogene 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (5 hits/1256 screens)

    EBI GWAS Catalog

    Description
    Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog
    Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.
    EBI GWAS Catalog
    Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
    EBI GWAS Catalog
    Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
    EBI GWAS Catalog
    WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity  
    enables frizzled binding  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway PubMed 
    involved_in bone remodeling  
    involved_in canonical Wnt signaling pathway  
    involved_in cardiac epithelial to mesenchymal transition  
    involved_in cell fate commitment  
    involved_in keratinocyte differentiation PubMed 
    involved_in keratinocyte proliferation PubMed 
    involved_in negative regulation of apoptotic signaling pathway PubMed 
    involved_in neuron differentiation  
    involved_in optic cup formation involved in camera-type eye development PubMed 
    involved_in oxidative stress-induced premature senescence PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in replicative senescence PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 

    General protein information

    Preferred Names
    protein Wnt-16
    Names
    wingless-type MMTV integration site family member 16b
    wingless-type MMTV integration site family, member 16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029242.1 RefSeqGene

      Range
      8634..20738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016087.2NP_057171.2  protein Wnt-16 isoform 2

      See identical proteins and their annotated locations for NP_057171.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs from variant 1 at the 5' terminus including 5' UTR and the coding region for the N-terminus. It encodes a shorter isoform than variant 1.
      Source sequence(s)
      AF152584, AF169963
      Consensus CDS
      CCDS5780.1
      UniProtKB/TrEMBL
      A4D0W7, E9PH60
      Related
      ENSP00000355065.2, ENST00000361301.6
      Conserved Domains (1) summary
      pfam00110
      Location:42355
      wnt; wnt family
    2. NM_057168.2NP_476509.1  protein Wnt-16 isoform 1 precursor

      See identical proteins and their annotated locations for NP_476509.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs from variant 2 at the 5' terminus including 5' UTR and the coding region for the N-terminus. Isoform 1, encoded by this variant, is 90% identical to the mouse Wnt16 protein at the amino acid level.
      Source sequence(s)
      AC006364
      Consensus CDS
      CCDS5781.1
      UniProtKB/Swiss-Prot
      Q2M3G1, Q9UBV4, Q9Y5C0
      UniProtKB/TrEMBL
      A4D0W8
      Related
      ENSP00000222462.2, ENST00000222462.3
      Conserved Domains (1) summary
      pfam00110
      Location:52365
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      121325367..121341104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      122640682..122656420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.