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    ERBB2 erb-b2 receptor tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 2064, updated on 10-Dec-2024

    Summary

    Official Symbol
    ERBB2provided by HGNC
    Official Full Name
    erb-b2 receptor tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:3430
    See related
    Ensembl:ENSG00000141736 MIM:164870; AllianceGenome:HGNC:3430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2)
    Summary
    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 34.7), skin (RPKM 30.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ERBB2 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39688094..39728658)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40551660..40592218)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37844347..37884911)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12101 Neighboring gene VISTA enhancer hs1769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37835782-37836282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12103 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:37845149-37846109 Neighboring gene phenylethanolamine N-methyltransferase Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene Sharpr-MPRA regulatory region 353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37857299-37857800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37857801-37858300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37861047-37861919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37882556-37883528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8463 Neighboring gene microRNA 4728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37896451-37897048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37897647-37898244 Neighboring gene migration and invasion enhancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12106 Neighboring gene growth factor receptor bound protein 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12108 Neighboring gene IKAROS family zinc finger 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37934634-37934867 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37940879-37941109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12110 Neighboring gene MPRA-validated peak2840 silencer Neighboring gene MPRA-validated peak2841 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37991649-37992148 Neighboring gene keratin 8 pseudogene 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (96 hits/1321 screens)

    Associated conditions

    Description Tests
    Cetuximab response
    MedGen: CN077967 GeneReviews: Not available
    Compare labs
    Gastric cancer
    MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
    Compare labs
    Glioma susceptibility 1
    MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
    Compare labs
    Lung cancer
    MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
    Compare labs
    Ovarian neoplasm
    MedGen: C0919267 GeneReviews: Not available
    Compare labs
    Panitumumab response
    MedGen: CN077999 GeneReviews: Not available
    Compare labs
    Pertuzumab response
    MedGen: CN233145 GeneReviews: Not available
    Compare labs
    Trastuzumab response
    MedGen: CN078025 GeneReviews: Not available
    Compare labs
    Visceral neuropathy, familial, 2, autosomal recessive
    MedGen: C5561950 OMIM: 619465 GeneReviews: Not available
    Compare labs

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 33
    Function Evidence Code Pubs
    enables ATP binding  
    enables ErbB-3 class receptor binding PubMed 
    enables GPI-linked ephrin receptor activity  
    enables RNA polymerase I core binding PubMed 
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables coreceptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    contributes_to growth factor binding PubMed 
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding PubMed 
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables receptor tyrosine kinase binding PubMed 
    enables signaling receptor binding PubMed 
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane signaling receptor activity PubMed 
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 33
    Items 1 - 25 of 58
    Process Evidence Code Pubs
    involved_in ERBB2-EGFR signaling pathway PubMed 
    involved_in ERBB2-ERBB3 signaling pathway  
    involved_in ERBB2-ERBB4 signaling pathway  
    involved_in Kit signaling pathway  
    involved_in Schwann cell development  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell population proliferation PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway PubMed 
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in enzyme-linked receptor protein signaling pathway PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in heart development  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in immature T cell proliferation in thymus  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in intracellular signal transduction PubMed 
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in motor neuron axon guidance  
    involved_in multicellular organism development  
    involved_in myelination  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of immature T cell proliferation in thymus  
    involved_in neurogenesis  
    involved_in neuromuscular junction development  
    involved_in neuron differentiation  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane  
    involved_in oligodendrocyte differentiation  
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of MAP kinase activity PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of Rho protein signal transduction  
    involved_in positive regulation of cell adhesion PubMed 
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of epithelial cell proliferation PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein targeting to membrane PubMed 
    involved_in positive regulation of transcription by RNA polymerase I PubMed 
    involved_in positive regulation of translation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of ERK1 and ERK2 cascade PubMed 
    involved_in regulation of angiogenesis PubMed 
    involved_in regulation of microtubule-based process PubMed 
    involved_in semaphorin-plexin signaling pathway  
    involved_in signal transduction PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in wound healing PubMed 
    Items 1 - 25 of 58
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    part_of ERBB3:ERBB2 complex PubMed 
    located_in apical plasma membrane  
    is_active_in basal plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in cytosol  
    located_in early endosome  
    located_in endosome membrane PubMed 
    located_in membrane PubMed 
    located_in myelin sheath  
    located_in neuromuscular junction  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in presynaptic membrane  
    part_of receptor complex  
    part_of receptor complex PubMed 
    part_of receptor complex PubMed 
    located_in ruffle membrane  
    part_of semaphorin receptor complex  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    receptor tyrosine-protein kinase erbB-2
    Names
    c-erb B2/neu protein
    herstatin
    human epidermal growth factor receptor 2
    metastatic lymph node gene 19 protein
    neuro/glioblastoma derived oncogene homolog
    neuroblastoma/glioblastoma derived oncogene homolog
    proto-oncogene Neu
    proto-oncogene c-ErbB-2
    tyrosine kinase-type cell surface receptor HER2
    v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
    v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
    v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
    NP_001005862.1
    NP_001276865.1
    NP_001276866.1
    NP_001276867.1
    NP_001369711.1
    NP_001369712.1
    NP_001369713.1
    NP_001369714.1
    NP_001369715.1
    NP_001369716.1
    NP_001369717.1
    NP_001369718.1
    NP_001369719.1
    NP_001369720.1
    NP_001369721.1
    NP_001369722.1
    NP_001369723.1
    NP_001369724.1
    NP_001369725.1
    NP_001369726.1
    NP_001369727.1
    NP_001369728.1
    NP_001369729.1
    NP_001369730.1
    NP_001369731.1
    NP_001369732.1
    NP_001369733.1
    NP_001369734.1
    NP_001369735.1
    NP_004439.2
    XP_047291546.1
    XP_054171396.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007503.1 RefSeqGene

      Range
      4945..45523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_724

    mRNA and Protein(s)

    1. NM_001005862.3 → NP_001005862.1  receptor tyrosine-protein kinase erbB-2 isoform b

      See identical proteins and their annotated locations for NP_001005862.1

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS45667.1
      UniProtKB/Swiss-Prot
      P04626
      Related
      ENSP00000462438.1, ENST00000584601.5
      Conserved Domains (5) summary
      cd12094
      Location:611 → 654
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:682 → 960
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:159 → 308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22 → 143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481 → 613
      GF_recep_IV; Growth factor receptor domain IV
    2. NM_001289936.2 → NP_001276865.1  receptor tyrosine-protein kinase erbB-2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS74052.1
      UniProtKB/Swiss-Prot
      P04626
      Related
      ENSP00000446466.1, ENST00000541774.5
      Conserved Domains (8) summary
      cd12094
      Location:626 → 669
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      smart00261
      Location:542 → 588
      FU; Furin-like repeats
      cd00064
      Location:220 → 265
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05109
      Location:697 → 975
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:174 → 323
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:37 → 158
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:705 → 961
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:496 → 628
      GF_recep_IV; Growth factor receptor domain IV
    3. NM_001289937.2 → NP_001276866.1  receptor tyrosine-protein kinase erbB-2 isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS77016.1
      UniProtKB/TrEMBL
      J3QLU9
      Related
      ENSP00000463714.1, ENST00000584450.5
      Conserved Domains (8) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      smart00261
      Location:557 → 603
      FU; Furin-like repeats
      cd00064
      Location:235 → 280
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05109
      Location:712 → 990
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:720 → 976
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
    4. NM_001289938.2 → NP_001276867.1  receptor tyrosine-protein kinase erbB-2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC087491
      Consensus CDS
      CCDS77017.1
      UniProtKB/TrEMBL
      B4DLA2, F5H1T4
      Related
      ENSP00000462808.1, ENST00000578199.5
      Conserved Domains (5) summary
      smart00261
      Location:527 → 573
      FU; Furin-like repeats
      cd00064
      Location:205 → 250
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:159 → 308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22 → 143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481 → 603
      GF_recep_IV; Growth factor receptor domain IV
    5. NM_001382782.1 → NP_001369711.1  receptor tyrosine-protein kinase erbB-2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS45667.1
      Conserved Domains (5) summary
      cd12094
      Location:611 → 654
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:682 → 960
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:159 → 308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22 → 143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481 → 613
      GF_recep_IV; Growth factor receptor domain IV
    6. NM_001382783.1 → NP_001369712.1  receptor tyrosine-protein kinase erbB-2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS45667.1
      Conserved Domains (5) summary
      cd12094
      Location:611 → 654
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:682 → 960
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:159 → 308
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:22 → 143
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:481 → 613
      GF_recep_IV; Growth factor receptor domain IV
    7. NM_001382784.1 → NP_001369713.1  receptor tyrosine-protein kinase erbB-2 isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:680 → 723
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:751 → 1029
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:550 → 682
      GF_recep_IV; Growth factor receptor domain IV
    8. NM_001382785.1 → NP_001369714.1  receptor tyrosine-protein kinase erbB-2 isoform g precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:675 → 718
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:746 → 1024
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 677
      GF_recep_IV; Growth factor receptor domain IV
    9. NM_001382786.1 → NP_001369715.1  receptor tyrosine-protein kinase erbB-2 isoform h precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:680 → 723
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:1090 → 1219
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:550 → 682
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:751 → 1017
      PKc_like; Protein Kinases, catalytic domain
    10. NM_001382787.1 → NP_001369716.1  receptor tyrosine-protein kinase erbB-2 isoform i precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:666 → 709
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:737 → 1015
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:214 → 363
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 198
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:536 → 668
      GF_recep_IV; Growth factor receptor domain IV
    11. NM_001382788.1 → NP_001369717.1  receptor tyrosine-protein kinase erbB-2 isoform j precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:651 → 694
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:722 → 1000
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:521 → 653
      GF_recep_IV; Growth factor receptor domain IV
    12. NM_001382789.1 → NP_001369718.1  receptor tyrosine-protein kinase erbB-2 isoform k precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:648 → 691
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:719 → 997
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:518 → 650
      GF_recep_IV; Growth factor receptor domain IV
    13. NM_001382790.1 → NP_001369719.1  receptor tyrosine-protein kinase erbB-2 isoform l precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:640 → 683
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:711 → 989
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 642
      GF_recep_IV; Growth factor receptor domain IV
    14. NM_001382791.1 → NP_001369720.1  receptor tyrosine-protein kinase erbB-2 isoform m precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:638 → 681
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:709 → 987
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:186 → 335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 170
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:508 → 640
      GF_recep_IV; Growth factor receptor domain IV
    15. NM_001382792.1 → NP_001369721.1  receptor tyrosine-protein kinase erbB-2 isoform n precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:1051 → 1180
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712 → 978
      PKc_like; Protein Kinases, catalytic domain
    16. NM_001382793.1 → NP_001369722.1  receptor tyrosine-protein kinase erbB-2 isoform o precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:1049 → 1178
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712 → 976
      PKc_like; Protein Kinases, catalytic domain
    17. NM_001382794.1 → NP_001369723.1  receptor tyrosine-protein kinase erbB-2 isoform p precorsor precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:698 → 976
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
    18. NM_001382795.1 → NP_001369724.1  receptor tyrosine-protein kinase erbB-2 isoform q precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (4) summary
      cd05109
      Location:696 → 974
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 633
      GF_recep_IV; Growth factor receptor domain IV
    19. NM_001382796.1 → NP_001369725.1  receptor tyrosine-protein kinase erbB-2 isoform r precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:712 → 990
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
    20. NM_001382797.1 → NP_001369726.1  receptor tyrosine-protein kinase erbB-2 isoform s precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:1030 → 1159
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712 → 957
      PKc_like; Protein Kinases, catalytic domain
    21. NM_001382798.1 → NP_001369727.1  receptor tyrosine-protein kinase erbB-2 isoform t precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:1011 → 1140
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712 → 938
      PKc_like; Protein Kinases, catalytic domain
    22. NM_001382799.1 → NP_001369728.1  receptor tyrosine-protein kinase erbB-2 isoform u precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:581 → 624
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:652 → 930
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:148 → 278
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 147
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:451 → 583
      GF_recep_IV; Growth factor receptor domain IV
    23. NM_001382800.1 → NP_001369729.1  receptor tyrosine-protein kinase erbB-2 isoform v precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:1001 → 1130
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712 → 928
      PKc_like; Protein Kinases, catalytic domain
    24. NM_001382801.1 → NP_001369730.1  receptor tyrosine-protein kinase erbB-2 isoform w precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      COG3170
      Location:995 → 1124
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 633
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:696 → 922
      PKc_like; Protein Kinases, catalytic domain
    25. NM_001382802.1 → NP_001369731.1  receptor tyrosine-protein kinase erbB-2 isoform x precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:555 → 598
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:626 → 904
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:201 → 252
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:425 → 557
      GF_recep_IV; Growth factor receptor domain IV
    26. NM_001382803.1 → NP_001369732.1  receptor tyrosine-protein kinase erbB-2 isoform y precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (5) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712 → 976
      PKc_like; Protein Kinases, catalytic domain
    27. NM_001382804.1 → NP_001369733.1  receptor tyrosine-protein kinase erbB-2 isoform z precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Consensus CDS
      CCDS92296.1
      UniProtKB/TrEMBL
      B4DTR1
      Related
      ENSP00000404047.2, ENST00000445658.6
      Conserved Domains (5) summary
      cd12094
      Location:365 → 408
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      cd05109
      Location:436 → 714
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:25 → 62
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:90 → 206
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:235 → 367
      GF_recep_IV; Growth factor receptor domain IV
    28. NM_001382805.1 → NP_001369734.1  receptor tyrosine-protein kinase erbB-2 isoform aa precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (6) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      COG3170
      Location:746 → 875
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:712 → 736
      PKc_like; Protein Kinases, catalytic domain
    29. NM_001382806.1 → NP_001369735.1  receptor tyrosine-protein kinase erbB-2 isoform bb precursor

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Conserved Domains (4) summary
      COG3170
      Location:717 → 846
      FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      cl21453
      Location:406 → 644
      PKc_like; Protein Kinases, catalytic domain
    30. NM_004448.4 → NP_004439.2  receptor tyrosine-protein kinase erbB-2 isoform a precursor

      See identical proteins and their annotated locations for NP_004439.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC079199, AC087491, BC167147
      Consensus CDS
      CCDS32642.1
      UniProtKB/Swiss-Prot
      B2RZG3, B4DHN3, P04626, Q14256, Q6LDV1, Q9UMK4, X5D2V5
      UniProtKB/TrEMBL
      X5DNK3
      Related
      ENSP00000269571.4, ENST00000269571.10
      Conserved Domains (8) summary
      cd12094
      Location:641 → 684
      TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
      smart00261
      Location:557 → 603
      FU; Furin-like repeats
      cd00064
      Location:235 → 280
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05109
      Location:712 → 990
      PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
      pfam00757
      Location:189 → 338
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:52 → 173
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:720 → 976
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:511 → 643
      GF_recep_IV; Growth factor receptor domain IV

    RNA

    1. NR_110535.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079199, AC087491
      Related
      ENST00000578373.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      39688094..39728658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435590.1 → XP_047291546.1  receptor tyrosine-protein kinase erbB-2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      40551660..40592218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315421.1 → XP_054171396.1  receptor tyrosine-protein kinase erbB-2 isoform X1

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