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    CD72 CD72 molecule [ Homo sapiens (human) ]

    Gene ID: 971, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CD72provided by HGNC
    Official Full Name
    CD72 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1696
    See related
    Ensembl:ENSG00000137101 MIM:107272; AllianceGenome:HGNC:1696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYB2; CD72b
    Summary
    Enables transmembrane signaling receptor activity. Involved in negative regulation of B cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lymph node (RPKM 32.2), spleen (RPKM 30.4) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD72 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35609982..35646857, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35630646..35667363, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35609979..35618410, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 17 Neighboring gene Sharpr-MPRA regulatory region 2201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19867 Neighboring gene Sharpr-MPRA regulatory region 203 Neighboring gene testis associated actin remodelling kinase 1 Neighboring gene microRNA 4667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35615974-35616825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28327 Neighboring gene uncharacterized LOC124902148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28328 Neighboring gene uncharacterized LOC101926948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19870 Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35657053-35657561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35657562-35658069 Neighboring gene RNA component of mitochondrial RNA processing endoribonuclease

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CD72 is a pan-tumor antigen associated to pediatric acute leukemia. Buldini B, et al. Cytometry A, 2023 Dec. PMID 37876342
    2. CD72 polymorphism associated with child-onset of idiopathic thrombocytopenic purpura in Chinese patients. Xu J, et al. J Clin Immunol, 2008 May. PMID 18071878
    3. Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus. Kaneko U, et al. Pediatr Allergy Immunol, 2006 Dec. PMID 17121583
    4. CD72-mediated suppression of human naive B cell differentiation by down-regulating X-box binding protein 1. Yamazaki T, et al. Eur J Immunol, 2005 Aug. PMID 16047337
    5. Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. Hitomi Y, et al. BMC Immunol, 2012 Dec 26. PMID 23268649, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD72 is a pan-tumor antigen associated to pediatric acute leukemia.
      Title: CD72 is a pan-tumor antigen associated to pediatric acute leukemia.
    2. CD72, a new immune checkpoint molecule, is a novel prognostic biomarker for kidney renal clear cell carcinoma.
      Title: CD72, a new immune checkpoint molecule, is a novel prognostic biomarker for kidney renal clear cell carcinoma.
    3. CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus.
      Title: CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus.
    4. Blockage of CD72 reduces B cell proliferation in immune thrombocytopenic purpura, involving interleukin 1 and macrophage migration inhibitory factor secretion.
      Title: Blockage of CD72 reduces B cell proliferation in immune thrombocytopenic purpura, involving interleukin 1 and macrophage migration inhibitory factor secretion.
    5. CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case-control study.
      Title: CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case-control study.
    6. A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome.
      Title: A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome.
    7. Interferon-alpha-induced CD100 expression on naive CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction.
      Title: Interferon-α-induced CD100 on naïve CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction.
    8. Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis
      Title: Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis.
    9. CD72 expression on activated B cells of SLE patients was significantly lower than that of normal controls. sema3A enhanced CD72 expression of B cells, but it was still lower in SLE patients than in normal individuals.
      Title: A regulatory role for CD72 expression on B cells in systemic lupus erythematosus.
    10. data demonstrated aberrant expression of CD72 exists on B cells of myasthenia gravis and multiple sclerosis patients and expression level of CD72 molecule has a significantly negative correlation with anti-AchR antibody levels in myasthenia gravis
      Title: Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis and multiple sclerosis.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    B-cell differentiation antigen CD72
    Names
    CD72 antigen
    lyb-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001782.3 → NP_001773.1  B-cell differentiation antigen CD72

      See identical proteins and their annotated locations for NP_001773.1

      Status: VALIDATED

      Source sequence(s)
      AL357874, BC030227, M54992
      Consensus CDS
      CCDS6581.1
      UniProtKB/Swiss-Prot
      P21854
      UniProtKB/TrEMBL
      Q5TLF7, Q5TLG0, Q5TLG3
      Related
      ENSP00000259633.4, ENST00000259633.9
      Conserved Domains (2) summary
      smart00034
      Location:233 → 351
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      TIGR04211
      Location:117 → 219
      SH3_and_anchor; SH3 domain protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      35609982..35646857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424154.1 → XP_047280110.1  B-cell differentiation antigen CD72 isoform X2

      UniProtKB/TrEMBL
      Q0H7P2

    2. XM_047424155.1 → XP_047280111.1  B-cell differentiation antigen CD72 isoform X2

      UniProtKB/TrEMBL
      Q0H7P2

    3. XM_006716893.3 → XP_006716956.1  B-cell differentiation antigen CD72 isoform X1

      UniProtKB/TrEMBL
      Q5TLF7, Q5TLG0
      Conserved Domains (2) summary
      pfam08826
      Location:168 → 223
      DMPK_coil; DMPK coiled coil domain like
      smart00034
      Location:233 → 319
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

    4. XM_047424156.1 → XP_047280112.1  B-cell differentiation antigen CD72 isoform X3

      UniProtKB/TrEMBL
      Q0H7P2

    5. XM_047424157.1 → XP_047280113.1  B-cell differentiation antigen CD72 isoform X4

      UniProtKB/TrEMBL
      Q5T4Q8
      Related
      ENSP00000367688.1, ENST00000378431.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      35630646..35667363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364281.1 → XP_054220256.1  B-cell differentiation antigen CD72 isoform X2

      UniProtKB/TrEMBL
      Q0H7P2

    2. XM_054364282.1 → XP_054220257.1  B-cell differentiation antigen CD72 isoform X2

      UniProtKB/TrEMBL
      Q0H7P2

    3. XM_054364280.1 → XP_054220255.1  B-cell differentiation antigen CD72 isoform X1

      UniProtKB/TrEMBL
      Q5TLF7, Q5TLG0

    4. XM_054364283.1 → XP_054220258.1  B-cell differentiation antigen CD72 isoform X3

      UniProtKB/TrEMBL
      Q0H7P2

    5. XM_054364284.1 → XP_054220259.1  B-cell differentiation antigen CD72 isoform X4

      UniProtKB/TrEMBL
      Q5T4Q8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21854.1 GenPept UniProtKB/Swiss-Prot:P21854

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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