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    DOCK3 dedicator of cytokinesis 3 [ Homo sapiens (human) ]

    Gene ID: 1795, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DOCK3provided by HGNC
    Official Full Name
    dedicator of cytokinesis 3provided by HGNC
    Primary source
    HGNC:HGNC:2989
    See related
    Ensembl:ENSG00000088538 MIM:603123; AllianceGenome:HGNC:2989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PBP; MOCA; NEDIDHA
    Summary
    This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
    Expression
    Biased expression in brain (RPKM 7.9), thyroid (RPKM 4.0) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DOCK3 in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    61
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (50674927..51384198)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (50704905..51414618)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50712358..51421629)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50654302-50655255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50655256-50656208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50662917-50663693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50684509-50685008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50686500-50687053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50689443-50690376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50688509-50689442 Neighboring gene MAPK activated protein kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14406 Neighboring gene long intergenic non-protein coding RNA 2019 Neighboring gene cytokine inducible SH2 containing protein Neighboring gene microRNA 4787 Neighboring gene peptidylprolyl isomerase A pseudogene 69 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:50828090-50828836 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50855181-50855760 Neighboring gene zinc finger protein 652 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19915 Neighboring gene NANOG hESC enhancer GRCh37_chr3:50928312-50928861 Neighboring gene Sharpr-MPRA regulatory region 894 Neighboring gene ST13, Hsp70 interacting protein pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14407 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:51263456-51264655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:51377300-51378184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51430225-51430730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:51430731-51431238 Neighboring gene RNA binding motif protein 15B Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene mesencephalic astrocyte derived neurotrophic factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling. Caspi E, et al. Mol Biol Cell, 2008 Nov. PMID 18716063, Free PMC Article
    2. Variants in DOCK3 cause developmental delay and hypotonia. Wiltrout K, et al. Eur J Hum Genet, 2019 Aug. PMID 30976111, Free PMC Article
    3. [Role of Dock3 in axonal regeneration]. Namekata K, et al. Seikagaku, 2012 May. PMID 22746061
    4. DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia. Iwata-Otsubo A, et al. Am J Med Genet A, 2018 Jan. PMID 29130632, Free PMC Article
    5. Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation. Chen Q, et al. Am J Pathol, 2001 Nov. PMID 11696419, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies.
      Title: DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies.
    2. hree patients with genetic variants in the dedicator of cytokinesis 3 (DOCK3) who presented with global developmental delay (GDD), hypotonia, and wide-based or uncoordinated gait.
      Title: Variants in DOCK3 cause developmental delay and hypotonia.
    3. here we report a second case of biallelic DOCK3 mutation due to homozygous deletion. Given the clinical similarities among the cases with DOCK3 mutations, we provided further evidence that biallelic mutations of DOCK3 lead to a specific DOCK3-related neurodevelopmental syndrome
      Title: DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.
    4. Common features in both affected individuals include severe developmental disability, ataxic gait, and severe hypotonia, which recapitulates the Dock3 knockout mouse phenotype. We show that complete DOCK3 deficiency in humans leads to developmental disability with significant hypotonia and gait ataxia, probably due to abnormal axonal development
      Title: Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability.
    5. Inhibition of Dock3 by Dock3 shRNA impaired the severity of status epilepticus in the acute stage and decreased the spontaneous recurrent seizures times in the chronic stage of lithium-pilocarpine model and decreased the expression of rac1-GTP.
      Title: Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models.
    6. Results supported that miR-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 in NSCLC A549 and H1299 cell lines.
      Title: Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer.
    7. It plays a role in axonal regeneration. (review)
      Title: [Role of Dock3 in axonal regeneration].
    8. MOCA is a key molecule of the Alzheimer disease-relevant neuronal death signals that links the presenilin-mediated death signal with the APP-mediated death signal at a point between Rac1 or Cdc42 and ASK1.
      Title: MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex
      Title: Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia
    MedGen: C4749014 OMIM: 618292 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Identification of a melanoma susceptibility locus and somatic mutation in TET2.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0299

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 3
    Names
    modifier of cell adhesion
    presenilin-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028012.2 RefSeqGene

      Range
      4687..713958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004947.5 → NP_004938.1  dedicator of cytokinesis protein 3

      See identical proteins and their annotated locations for NP_004938.1

      Status: REVIEWED

      Source sequence(s)
      AC096920, AY254099, BC045793
      Consensus CDS
      CCDS46835.1
      UniProtKB/Swiss-Prot
      O15017, Q8IZD9
      UniProtKB/TrEMBL
      A0A2X0SFH6
      Related
      ENSP00000266037.8, ENST00000266037.10
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1235 → 1626
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      50674927..51384198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264914.4 → XP_005264971.1  dedicator of cytokinesis protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1235 → 1626
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    2. XM_006713010.4 → XP_006713073.1  dedicator of cytokinesis protein 3 isoform X19

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1235 → 1626
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    3. XM_005264915.4 → XP_005264972.1  dedicator of cytokinesis protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1235 → 1626
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    4. XM_017005825.3 → XP_016861314.1  dedicator of cytokinesis protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFH6

    5. XM_006713008.4 → XP_006713071.1  dedicator of cytokinesis protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1235 → 1626
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    6. XM_047447600.1 → XP_047303556.1  dedicator of cytokinesis protein 3 isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFH6

    7. XM_006713009.4 → XP_006713072.1  dedicator of cytokinesis protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1235 → 1597
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    8. XM_047447602.1 → XP_047303558.1  dedicator of cytokinesis protein 3 isoform X16

      UniProtKB/TrEMBL
      A0A2X0SFH6

    9. XM_047447603.1 → XP_047303559.1  dedicator of cytokinesis protein 3 isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFH6

    10. XM_005264916.5 → XP_005264973.1  dedicator of cytokinesis protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1226 → 1617
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    11. XM_047447597.1 → XP_047303553.1  dedicator of cytokinesis protein 3 isoform X11

      UniProtKB/TrEMBL
      A0A2X0SFH6

    12. XM_047447598.1 → XP_047303554.1  dedicator of cytokinesis protein 3 isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFH6

    13. XM_047447604.1 → XP_047303560.1  dedicator of cytokinesis protein 3 isoform X20

      UniProtKB/TrEMBL
      A0A2X0SFH6

    14. XM_005264917.4 → XP_005264974.1  dedicator of cytokinesis protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1221 → 1612
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    15. XM_047447595.1 → XP_047303551.1  dedicator of cytokinesis protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFH6

    16. XM_047447596.1 → XP_047303552.1  dedicator of cytokinesis protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SFH6

    17. XM_047447601.1 → XP_047303557.1  dedicator of cytokinesis protein 3 isoform X15

      UniProtKB/TrEMBL
      A0A2X0SFH6

    18. XM_005264918.5 → XP_005264975.1  dedicator of cytokinesis protein 3 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1186 → 1577
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    19. XM_047447599.1 → XP_047303555.1  dedicator of cytokinesis protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A2X0SFH6

    20. XM_017005826.3 → XP_016861315.1  dedicator of cytokinesis protein 3 isoform X18

      UniProtKB/TrEMBL
      A0A2X0SFH6

    21. XM_047447605.1 → XP_047303561.1  dedicator of cytokinesis protein 3 isoform X21

      UniProtKB/TrEMBL
      A0A2X0SFH6

    22. XM_017005827.3 → XP_016861316.1  dedicator of cytokinesis protein 3 isoform X22

      UniProtKB/TrEMBL
      A0A2X0SFH6

    23. XM_047447606.1 → XP_047303562.1  dedicator of cytokinesis protein 3 isoform X24

      UniProtKB/TrEMBL
      A0A2X0SFH6

    24. XM_011533441.4 → XP_011531743.1  dedicator of cytokinesis protein 3 isoform X23

      UniProtKB/TrEMBL
      A0A2X0SFH6
      Conserved Domains (3) summary
      cd08695
      Location:75 → 264
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:890 → 1281
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:2 → 67
      DOCK_N; DOCK N-terminus

    25. XM_011533443.3 → XP_011531745.1  dedicator of cytokinesis protein 3 isoform X25

      See identical proteins and their annotated locations for XP_011531745.1

      Conserved Domains (2) summary
      cd11704
      Location:339 → 730
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cl09913
      Location:233 → 349
      Csn2_like; CRISPR/Cas system-associated protein Csn2

    26. XM_011533445.3 → XP_011531747.1  dedicator of cytokinesis protein 3 isoform X26

      Conserved Domains (2) summary
      cd11704
      Location:281 → 672
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cl09913
      Location:175 → 291
      Csn2_like; CRISPR/Cas system-associated protein Csn2

    27. XM_011533444.3 → XP_011531746.1  dedicator of cytokinesis protein 3 isoform X25

      See identical proteins and their annotated locations for XP_011531746.1

      Conserved Domains (2) summary
      cd11704
      Location:339 → 730
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cl09913
      Location:233 → 349
      Csn2_like; CRISPR/Cas system-associated protein Csn2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      50704905..51414618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345503.1 → XP_054201478.1  dedicator of cytokinesis protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFH6

    2. XM_054345521.1 → XP_054201496.1  dedicator of cytokinesis protein 3 isoform X19

      UniProtKB/TrEMBL
      A0A2X0SFH6

    3. XM_054345504.1 → XP_054201479.1  dedicator of cytokinesis protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFH6

    4. XM_054345511.1 → XP_054201486.1  dedicator of cytokinesis protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFH6

    5. XM_054345507.1 → XP_054201482.1  dedicator of cytokinesis protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFH6

    6. XM_054345516.1 → XP_054201491.1  dedicator of cytokinesis protein 3 isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFH6

    7. XM_054345510.1 → XP_054201485.1  dedicator of cytokinesis protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFH6

    8. XM_054345518.1 → XP_054201493.1  dedicator of cytokinesis protein 3 isoform X16

      UniProtKB/TrEMBL
      A0A2X0SFH6

    9. XM_054345519.1 → XP_054201494.1  dedicator of cytokinesis protein 3 isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFH6

    10. XM_054345505.1 → XP_054201480.1  dedicator of cytokinesis protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFH6

    11. XM_054345513.1 → XP_054201488.1  dedicator of cytokinesis protein 3 isoform X11

      UniProtKB/TrEMBL
      A0A2X0SFH6

    12. XM_054345514.1 → XP_054201489.1  dedicator of cytokinesis protein 3 isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFH6

    13. XM_054345522.1 → XP_054201497.1  dedicator of cytokinesis protein 3 isoform X20

      UniProtKB/TrEMBL
      A0A2X0SFH6

    14. XM_054345506.1 → XP_054201481.1  dedicator of cytokinesis protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFH6

    15. XM_054345508.1 → XP_054201483.1  dedicator of cytokinesis protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFH6

    16. XM_054345509.1 → XP_054201484.1  dedicator of cytokinesis protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SFH6

    17. XM_054345517.1 → XP_054201492.1  dedicator of cytokinesis protein 3 isoform X15

      UniProtKB/TrEMBL
      A0A2X0SFH6

    18. XM_054345512.1 → XP_054201487.1  dedicator of cytokinesis protein 3 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFH6

    19. XM_054345515.1 → XP_054201490.1  dedicator of cytokinesis protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A2X0SFH6

    20. XM_054345520.1 → XP_054201495.1  dedicator of cytokinesis protein 3 isoform X18

      UniProtKB/TrEMBL
      A0A2X0SFH6

    21. XM_054345529.1 → XP_054201504.1  dedicator of cytokinesis protein 3 isoform X27

    22. XM_054345523.1 → XP_054201498.1  dedicator of cytokinesis protein 3 isoform X21

      UniProtKB/TrEMBL
      A0A2X0SFH6

    23. XM_054345524.1 → XP_054201499.1  dedicator of cytokinesis protein 3 isoform X22

      UniProtKB/TrEMBL
      A0A2X0SFH6

    24. XM_054345526.1 → XP_054201501.1  dedicator of cytokinesis protein 3 isoform X24

      UniProtKB/TrEMBL
      A0A2X0SFH6

    25. XM_054345525.1 → XP_054201500.1  dedicator of cytokinesis protein 3 isoform X23

      UniProtKB/TrEMBL
      A0A2X0SFH6

    26. XM_054345527.1 → XP_054201502.1  dedicator of cytokinesis protein 3 isoform X25

    27. XM_054345530.1 → XP_054201505.1  dedicator of cytokinesis protein 3 isoform X26

    28. XM_054345528.1 → XP_054201503.1  dedicator of cytokinesis protein 3 isoform X25

    29. XM_054345531.1 → XP_054201506.1  dedicator of cytokinesis protein 3 isoform X26

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZD9.1 GenPept UniProtKB/Swiss-Prot:Q8IZD9

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