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    IMP4 IMP U3 small nucleolar ribonucleoprotein 4 [ Homo sapiens (human) ]

    Gene ID: 92856, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IMP4provided by HGNC
    Official Full Name
    IMP U3 small nucleolar ribonucleoprotein 4provided by HGNC
    Primary source
    HGNC:HGNC:30856
    See related
    Ensembl:ENSG00000136718 MIM:612981; AllianceGenome:HGNC:30856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BXDC4
    Summary
    The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IMP4 in Genome Data Viewer
    Location:
    2q21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130342897..130347967)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130776821..130781891)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131100470..131105540)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (anticodon TTC) 1-1 Neighboring gene coiled-coil domain containing 115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11957 Neighboring gene protein tyrosine phosphatase non-receptor type 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:131129403-131130030 Neighboring gene uncharacterized LOC105373618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Components of U3 snoRNA-containing complexes shuttle between nuclei and the cytoplasm and differentially localize in nucleoli: implications for assembly and function. Leary DJ, et al. Mol Biol Cell, 2004 Jan. PMID 14565981, Free PMC Article
    2. DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4. Liu C, et al. Thorac Cancer, 2021 Jun. PMID 33973712, Free PMC Article
    3. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Granneman S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655004, Free PMC Article
    4. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. Jäkel S, et al. EMBO J, 2002 Feb 1. PMID 11823430, Free PMC Article
    5. Nucleolar maturation of the human small subunit processome. Singh S, et al. Science, 2021 Sep 10. PMID 34516797, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4.
      Title: DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC19606

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA primary transcript binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mpp10 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Mpp10 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U3 small nucleolar ribonucleoprotein protein IMP4
    Names
    IMP4 homolog, U3 small nucleolar ribonucleoprotein
    IMP4, U3 small nucleolar ribonucleoprotein, homolog
    U3 snoRNP protein 4 homolog
    U3 snoRNP protein IMP4
    brix domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320304.2 → NP_001307233.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B8ZZ47
      Conserved Domains (1) summary
      smart00879
      Location:84 → 251
      Brix; The Brix domain is found in a number of eukaryotic proteins

    2. NM_001320305.2 → NP_001307234.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B8ZZ47
      Conserved Domains (1) summary
      smart00879
      Location:84 → 235
      Brix; The Brix domain is found in a number of eukaryotic proteins

    3. NM_001320306.2 → NP_001307235.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      E7ENR5, H0Y714
      Related
      ENSP00000409371.1, ENST00000452955.1
      Conserved Domains (1) summary
      smart00879
      Location:31 → 198
      Brix; The Brix domain is found in a number of eukaryotic proteins

    4. NM_001320307.2 → NP_001307236.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      E7ENR5, H0Y714
      Related
      ENSP00000389701.1, ENST00000428740.5
      Conserved Domains (1) summary
      smart00879
      Location:31 → 198
      Brix; The Brix domain is found in a number of eukaryotic proteins

    5. NM_001320309.2 → NP_001307238.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B9A008
      Related
      ENST00000460766.5
      Conserved Domains (1) summary
      smart00879
      Location:1 → 168
      Brix; The Brix domain is found in a number of eukaryotic proteins

    6. NM_001320310.2 → NP_001307239.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B9A008
      Related
      ENSP00000386716.1, ENST00000409649.5
      Conserved Domains (1) summary
      smart00879
      Location:1 → 168
      Brix; The Brix domain is found in a number of eukaryotic proteins

    7. NM_001320311.2 → NP_001307240.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B9A008
      Conserved Domains (1) summary
      smart00879
      Location:1 → 165
      Brix; The Brix domain is found in a number of eukaryotic proteins

    8. NM_001371725.1 → NP_001358654.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC132479
      Conserved Domains (1) summary
      smart00879
      Location:86 → 281
      Brix; The Brix domain is found in a number of eukaryotic proteins

    9. NM_001371726.1 → NP_001358655.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC132479
      Conserved Domains (1) summary
      smart00879
      Location:86 → 269
      Brix; The Brix domain is found in a number of eukaryotic proteins

    10. NM_001371728.1 → NP_001358657.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B8ZZ47
      Conserved Domains (1) summary
      smart00879
      Location:86 → 252
      Brix; The Brix domain is found in a number of eukaryotic proteins

    11. NM_001371730.1 → NP_001358659.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC132479
      Conserved Domains (1) summary
      smart00879
      Location:1 → 196
      Brix; The Brix domain is found in a number of eukaryotic proteins

    12. NM_001371731.1 → NP_001358660.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B9A008
      Conserved Domains (1) summary
      smart00879
      Location:1 → 168
      Brix; The Brix domain is found in a number of eukaryotic proteins

    13. NM_001371732.1 → NP_001358661.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B9A008
      Conserved Domains (1) summary
      smart00879
      Location:1 → 168
      Brix; The Brix domain is found in a number of eukaryotic proteins

    14. NM_001371733.1 → NP_001358662.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B9A008
      Conserved Domains (1) summary
      smart00879
      Location:1 → 168
      Brix; The Brix domain is found in a number of eukaryotic proteins

    15. NM_001371734.1 → NP_001358663.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC132479
      UniProtKB/TrEMBL
      B9A008
      Conserved Domains (1) summary
      smart00879
      Location:1 → 168
      Brix; The Brix domain is found in a number of eukaryotic proteins

    16. NM_033416.3 → NP_219484.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform a

      See identical proteins and their annotated locations for NP_219484.1

      Status: REVIEWED

      Source sequence(s)
      AC132479
      Consensus CDS
      CCDS2160.1
      UniProtKB/Swiss-Prot
      Q3ZTT3, Q96G21
      UniProtKB/TrEMBL
      B8ZZ47
      Related
      ENSP00000259239.3, ENST00000259239.8
      Conserved Domains (1) summary
      smart00879
      Location:86 → 253
      Brix; The Brix domain is found in a number of eukaryotic proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      130342897..130347967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      130776821..130781891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96G21.1 GenPept UniProtKB/Swiss-Prot:Q96G21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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