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    POP4 POP4 homolog, ribonuclease P/MRP subunit [ Homo sapiens (human) ]

    Gene ID: 10775, updated on 10-Dec-2024

    Summary

    Official Symbol
    POP4provided by HGNC
    Official Full Name
    POP4 homolog, ribonuclease P/MRP subunitprovided by HGNC
    Primary source
    HGNC:HGNC:30081
    See related
    Ensembl:ENSG00000105171 MIM:606114; AllianceGenome:HGNC:30081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPP29
    Summary
    This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in testis (RPKM 7.0), lymph node (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See POP4 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (29606283..29617237)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (32131858..32142812)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30097190..30108144)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 340, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:29763000-29763195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14406 Neighboring gene VSTM2B divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29799690-29800520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29802083-29802584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29802585-29803084 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29814030-29814530 Neighboring gene MPRA-validated peak3428 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29862474-29863068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29863069-29863661 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50790 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29895755-29896381 Neighboring gene Sharpr-MPRA regulatory region 9443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29908074-29908807 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:29910274-29911005 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50884 Neighboring gene uncharacterized LOC124904683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30025281-30025781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30030190-30030690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30030691-30031191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30053547-30054047 Neighboring gene V-set and transmembrane domain containing 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30055952-30056800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30059413-30059913 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:30086866-30087366 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:30087367-30087867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:30100801-30101312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14409 Neighboring gene Sharpr-MPRA regulatory region 12961 Neighboring gene uncharacterized LOC105372353 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:30156127-30156680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:30156681-30157234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14413 Neighboring gene pleckstrin homology and FYVE domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr downregulates POP4 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables ribonuclease P RNA binding  
    enables ribonuclease P RNA binding PubMed 
    contributes_to ribonuclease P activity PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing  
    involved_in tRNA 5'-leader removal PubMed 
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex PubMed 
    located_in nucleolus PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    part_of ribonuclease MRP complex  
    part_of ribonuclease P complex  

    General protein information

    Preferred Names
    ribonuclease P protein subunit p29
    Names
    hPOP4
    NP_006618.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006627.3 → NP_006618.1  ribonuclease P protein subunit p29

      See identical proteins and their annotated locations for NP_006618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes processing of precursor 4.
      Source sequence(s)
      AC010505, BU727144, Y18863
      Consensus CDS
      CCDS12416.1
      UniProtKB/Swiss-Prot
      O95707, Q5XKL7, Q6FHW9, Q9UQQ3
      UniProtKB/TrEMBL
      K7ERD7
      Related
      ENSP00000465213.1, ENST00000585603.6
      Conserved Domains (1) summary
      pfam01868
      Location:128 → 210
      UPF0086; Domain of unknown function UPF0086

    RNA

    1. NR_027368.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010505, AK303791, BU727144
      Related
      ENST00000221770.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      29606283..29617237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      32131858..32142812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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