Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Pol
|
gag-pol
|
HIV-1 Pol is identified to have a physical interaction with protein phosphatase 2, catalytic subunit, beta isozyme (PPP2CB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
PubMed
|
Tat
|
tat
|
HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells |
PubMed
|
|
tat
|
An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression |
PubMed
|
Vpr
|
vpr
|
Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain |
PubMed
|
|
vpr
|
HIV-1 Vpr was found to upregulate PP2A in fission yeast |
PubMed
|
|
vpr
|
HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A |
PubMed
|
Vpu
|
vpu
|
IFN-alpha and IFN-beta increases SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism |
PubMed
|
nucleocapsid
|
gag
|
HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A |
PubMed
|
Go to the HIV-1, Human Interaction Database