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    IDO2 indoleamine 2,3-dioxygenase 2 [ Homo sapiens (human) ]

    Gene ID: 169355, updated on 10-Dec-2024

    Summary

    Official Symbol
    IDO2provided by HGNC
    Official Full Name
    indoleamine 2,3-dioxygenase 2provided by HGNC
    Primary source
    HGNC:HGNC:27269
    See related
    Ensembl:ENSG00000188676 MIM:612129; AllianceGenome:HGNC:27269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INDOL1
    Summary
    Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
    Expression
    Biased expression in placenta (RPKM 9.5), liver (RPKM 2.8) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IDO2 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (39934651..40016392)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (40211488..40293321)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (39792170..39873911)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 80 Neighboring gene Sharpr-MPRA regulatory region 12355 Neighboring gene polo like kinase 4 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:39807747-39808491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27279 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:39835255-39836184 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:39836330-39836562 Neighboring gene Sharpr-MPRA regulatory region 1248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27280 Neighboring gene nuclear transcription factor Y subunit beta pseudogene Neighboring gene Sharpr-MPRA regulatory region 3146 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:39908434-39908606 Neighboring gene HNF4 motif-containing MPRA enhancer 150 Neighboring gene long intergenic non-protein coding RNA 2866 Neighboring gene HNF1 motif-containing MPRA enhancer 269 Neighboring gene transcriptional and immune response regulator Neighboring gene NANOG hESC enhancer GRCh37_chr8:40077338-40077937 Neighboring gene NANOG hESC enhancer GRCh37_chr8:40194220-40194743 Neighboring gene SIRT1 regulating lncRNA tumor promoter

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (4 hits/382 screens)

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding  
    enables indoleamine 2,3-dioxygenase activity  
    enables indoleamine 2,3-dioxygenase activity PubMed 
    enables indoleamine 2,3-dioxygenase activity PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables tryptophan 2,3-dioxygenase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  

    General protein information

    Preferred Names
    indoleamine 2,3-dioxygenase 2
    Names
    indoleamine 2,3-dioxygenase-like 1 protein
    indoleamine 2,3-dioxygenase-like protein 1
    indoleamine-pyrrole 2,3 dioxygenase-like 1
    indoleamine-pyrrole 2,3-dioxygenase-like protein 1
    NP_001382135.1
    NP_919270.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395206.1 → NP_001382135.1  indoleamine 2,3-dioxygenase 2

      Status: VALIDATED

      Source sequence(s)
      AC007991, AC087518
      Consensus CDS
      CCDS6114.3
      UniProtKB/Swiss-Prot
      A4UD41, F5H5G0, Q6ZQW0
      Conserved Domains (1) summary
      pfam01231
      Location:15 → 401
      IDO; Indoleamine 2,3-dioxygenase
    2. NM_194294.5 → NP_919270.3  indoleamine 2,3-dioxygenase 2

      Status: VALIDATED

      Source sequence(s)
      AC007991, AC087518
      Consensus CDS
      CCDS6114.3
      UniProtKB/Swiss-Prot
      A4UD41, F5H5G0, Q6ZQW0
      Related
      ENSP00000443432.2, ENST00000502986.4
      Conserved Domains (1) summary
      pfam01231
      Location:15 → 401
      IDO; Indoleamine 2,3-dioxygenase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      39934651..40016392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      40211488..40293321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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