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    Irag1 inositol 1,4,5-triphosphate receptor associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 17540, updated on 9-Dec-2024

    Summary

    Official Symbol
    Irag1provided by MGI
    Official Full Name
    inositol 1,4,5-triphosphate receptor associated 1provided by MGI
    Primary source
    MGI:MGI:1338023
    See related
    Ensembl:ENSMUSG00000005611 AllianceGenome:MGI:1338023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irag; Ris1; Mrvi1
    Summary
    This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein participates in signaling by nitric oxide (NO) to inhibit intracellular calcium release and platelet aggregation in cardiovascular tissue. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
    Expression
    Biased expression in bladder adult (RPKM 34.2), subcutaneous fat pad adult (RPKM 20.8) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Irag1 in Genome Data Viewer
    Location:
    7 E3; 7 57.9 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110467464..110582116, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110868257..110982909, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene ring finger protein 141 Neighboring gene STARR-positive B cell enhancer ABC_E2250 Neighboring gene STARR-seq mESC enhancer starr_19833 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene STARR-seq mESC enhancer starr_19834 Neighboring gene predicted gene 16336 Neighboring gene STARR-seq mESC enhancer starr_19835 Neighboring gene STARR-seq mESC enhancer starr_19836 Neighboring gene STARR-positive B cell enhancer ABC_E9701 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene eukaryotic translation initiation factor 4, gamma 2 Neighboring gene predicted gene, 23262

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inositol 1,4,5-triphosphate receptor associated 1
    Names
    JAW1-related protein MRVI1
    MRV integration site 1
    inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
    inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
    murine retrovirus integration site 1 protein
    protein MRVI1
    retroviral integration site 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194464.3NP_919446.2  inositol 1,4,5-triphosphate receptor associated 1

      See identical proteins and their annotated locations for NP_919446.2

      Status: REVIEWED

      Source sequence(s)
      AC159206, AC184052, AK020536, AK141821
      Consensus CDS
      CCDS21749.1
      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Related
      ENSMUSP00000005751.7, ENSMUST00000005751.13
      Conserved Domains (1) summary
      pfam05781
      Location:272856
      MRVI1; MRVI1 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      110467464..110582116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507416.3XP_006507479.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

      See identical proteins and their annotated locations for XP_006507479.1

      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Related
      ENSMUSP00000114578.2, ENSMUST00000125758.8
      Conserved Domains (1) summary
      pfam05781
      Location:272856
      MRVI1; MRVI1 protein
    2. XM_006507415.4XP_006507478.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

      See identical proteins and their annotated locations for XP_006507478.1

      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Conserved Domains (1) summary
      pfam05781
      Location:272856
      MRVI1; MRVI1 protein
    3. XM_036152758.1XP_036008651.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

      UniProtKB/TrEMBL
      Q3UR44
      Conserved Domains (1) summary
      pfam05781
      Location:24608
      MRVI1; MRVI1 protein
    4. XM_006507418.5XP_006507481.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

      UniProtKB/TrEMBL
      Q3UR44
      Conserved Domains (1) summary
      pfam05781
      Location:24608
      MRVI1; MRVI1 protein
    5. XM_011241686.1XP_011239988.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U069, Q9R2C5, Q9WUX5
      Related
      ENSMUSP00000120045.2, ENSMUST00000127935.8
      Conserved Domains (2) summary
      pfam05781
      Location:289873
      MRVI1; MRVI1 protein
      cl19857
      Location:122213
      DUF2126; Putative amidoligase enzyme (DUF2126)
    6. XM_011241687.4XP_011239989.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X4

      Conserved Domains (1) summary
      pfam05781
      Location:337490
      MRVI1; MRVI1 protein

    RNA

    1. XR_869664.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010826.5: Suppressed sequence

      Description
      NM_010826.5: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.