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    Map3k7 mitogen-activated protein kinase kinase kinase 7 [ Mus musculus (house mouse) ]

    Gene ID: 26409, updated on 9-Dec-2024

    Summary

    Official Symbol
    Map3k7provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 7provided by MGI
    Primary source
    MGI:MGI:1346877
    See related
    Ensembl:ENSMUSG00000028284 AllianceGenome:MGI:1346877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tak1; B430101B05
    Summary
    Enables MAP kinase kinase activity; MAP kinase kinase kinase kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including anoikis; negative regulation of necroptotic process; and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including intracellular signaling cassette; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including brain; gut; male reproductive gland or organ; metanephros; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 14.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map3k7 in Genome Data Viewer
    Location:
    4 A5; 4 13.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (31963659..32023470)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (31963492..32023470)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42315 Neighboring gene STARR-seq mESC enhancer starr_09843 Neighboring gene STARR-seq mESC enhancer starr_09845 Neighboring gene STARR-seq mESC enhancer starr_09846 Neighboring gene STARR-seq mESC enhancer starr_09848 Neighboring gene predicted gene, 32412 Neighboring gene STARR-seq mESC enhancer starr_09849 Neighboring gene STARR-positive B cell enhancer ABC_E6156 Neighboring gene STARR-seq mESC enhancer starr_09851 Neighboring gene STARR-seq mESC enhancer starr_09853 Neighboring gene STARR-seq mESC enhancer starr_09854 Neighboring gene predicted gene, 26254 Neighboring gene STARR-positive B cell enhancer ABC_E7958 Neighboring gene STARR-positive B cell enhancer ABC_E10228 Neighboring gene predicted gene 11927 Neighboring gene STARR-seq mESC enhancer starr_09855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32251946-32252191 Neighboring gene STARR-seq mESC enhancer starr_09857 Neighboring gene STARR-seq mESC enhancer starr_09858 Neighboring gene predicted gene, 42266

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables MAP kinase kinase kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables linear polyubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type II transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within I-kappaB phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in I-kappaB phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-17A-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-33-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of ripoptosome assembly involved in necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 7
    Names
    TGF-beta-activated kinase 1
    transforming growth factor-beta-activated kinase 1
    NP_033342.1
    NP_766276.1
    XP_006538011.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009316.1NP_033342.1  mitogen-activated protein kinase kinase kinase 7 isoform B

      See identical proteins and their annotated locations for NP_033342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) represents the longer transcript and encodes the longer isoform (B).
      Source sequence(s)
      AK137046, AL833781, CV559615
      Consensus CDS
      CCDS51133.1
      UniProtKB/TrEMBL
      Q3TXG1, Q923A8
      Related
      ENSMUSP00000040307.5, ENSMUST00000037607.11
      Conserved Domains (1) summary
      cd14058
      Location:42292
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
    2. NM_172688.3NP_766276.1  mitogen-activated protein kinase kinase kinase 7 isoform A

      See identical proteins and their annotated locations for NP_766276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) lacks an in-frame coding segment, compared to variant B. The resulting isoform (A) lacks an internal region, as compared to isoform B.
      Source sequence(s)
      AK137046, AL833781
      Consensus CDS
      CCDS18014.1
      UniProtKB/Swiss-Prot
      Q62073
      UniProtKB/TrEMBL
      Q3TXG1, Q543B5
      Related
      ENSMUSP00000079734.7, ENSMUST00000080933.13
      Conserved Domains (1) summary
      cd14058
      Location:42292
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      31963659..32023470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537948.4XP_006538011.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1162
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_390323.5 RNA Sequence

    2. XR_004941909.1 RNA Sequence

    3. XR_004941907.1 RNA Sequence

    4. XR_004941908.1 RNA Sequence