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    GPALPP1 GPALPP motifs containing 1 [ Homo sapiens (human) ]

    Gene ID: 55425, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPALPP1provided by HGNC
    Official Full Name
    GPALPP motifs containing 1provided by HGNC
    Primary source
    HGNC:HGNC:20298
    See related
    Ensembl:ENSG00000133114 AllianceGenome:HGNC:20298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LSR7; AD029; KIAA1704; bA245H20.2
    Expression
    Ubiquitous expression in endometrium (RPKM 5.8), thyroid (RPKM 5.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPALPP1 in Genome Data Viewer
    Location:
    13q14.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (44989538..45037669)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44209620..44257727)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45563673..45611804)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7675 Neighboring gene tRNA-Glu (anticodon TTC) 2-1 Neighboring gene nuclear FMR1 interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 6953 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45563144-45563782 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45563783-45564419 Neighboring gene RNA, 7SL, cytoplasmic 49, pseudogene Neighboring gene uncharacterized LOC105370188 Neighboring gene uncharacterized LOC107984596 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:45629620-45630819

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Dec 31. PMID 11214970
    2. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Kumar A, et al. Cell Rep, 2022 May 10. PMID 35545047, Free PMC Article
    3. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. Lu L, et al. J Biol Chem, 2013 Dec 13. PMID 24163370, Free PMC Article
    4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article
    5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Elzi DJ, et al. J Proteome Res, 2014 Aug 1. PMID 24999758, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1704

    General protein information

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    Preferred Names
    GPALPP motifs-containing protein 1
    Names
    lipopolysaccharide specific response-7 protein
    lipopolysaccharide-specific response protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316951.2 → NP_001303880.1  GPALPP motifs-containing protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK292493, AL359706, CF528444, DC333111
      Consensus CDS
      CCDS9394.1
      UniProtKB/Swiss-Prot
      A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
      UniProtKB/TrEMBL
      A0A0A0MRI1
      Conserved Domains (1) summary
      pfam12572
      Location:196 → 332
      DUF3752; Protein of unknown function (DUF3752)

    2. NM_001316952.2 → NP_001303881.1  GPALPP motifs-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction and differs in the 3' UTR compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL138693, AL359706, BC032333, DC333111
      UniProtKB/Swiss-Prot
      Q8IXQ4
      Conserved Domains (1) summary
      pfam12572
      Location:73 → 209
      DUF3752; Protein of unknown function (DUF3752)

    3. NM_018559.5 → NP_061029.2  GPALPP motifs-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_061029.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL359706, BC039586, DC333111
      Consensus CDS
      CCDS9394.1
      UniProtKB/Swiss-Prot
      A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
      UniProtKB/TrEMBL
      A0A0A0MRI1
      Related
      ENSP00000368447.4, ENST00000379151.9
      Conserved Domains (1) summary
      pfam12572
      Location:196 → 332
      DUF3752; Protein of unknown function (DUF3752)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      44989538..45037669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430436.1 → XP_047286392.1  GPALPP motifs-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
      Related
      ENSP00000432500.1, ENST00000497558.5

    2. XM_005266444.4 → XP_005266501.1  GPALPP motifs-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005266501.1

      UniProtKB/Swiss-Prot
      A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
      UniProtKB/TrEMBL
      A0A0A0MRI1
      Conserved Domains (1) summary
      pfam12572
      Location:196 → 332
      DUF3752; Protein of unknown function (DUF3752)

    3. XM_047430438.1 → XP_047286394.1  GPALPP motifs-containing protein 1 isoform X4

    4. XM_011535144.3 → XP_011533446.1  GPALPP motifs-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011533446.1

      Conserved Domains (1) summary
      pfam12572
      Location:73 → 209
      DUF3752; Protein of unknown function (DUF3752)

    5. XM_047430437.1 → XP_047286393.1  GPALPP motifs-containing protein 1 isoform X3

      Related
      ENSP00000350145.3, ENST00000357537.4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      44209620..44257727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374668.1 → XP_054230643.1  GPALPP motifs-containing protein 1 isoform X1

    2. XM_054374669.1 → XP_054230644.1  GPALPP motifs-containing protein 1 isoform X1

    3. XM_054374672.1 → XP_054230647.1  GPALPP motifs-containing protein 1 isoform X4

    4. XM_054374670.1 → XP_054230645.1  GPALPP motifs-containing protein 1 isoform X2

    5. XM_054374671.1 → XP_054230646.1  GPALPP motifs-containing protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IXQ4.1 GenPept UniProtKB/Swiss-Prot:Q8IXQ4

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