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    ZNF827 zinc finger protein 827 [ Homo sapiens (human) ]

    Gene ID: 152485, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF827provided by HGNC
    Official Full Name
    zinc finger protein 827provided by HGNC
    Primary source
    HGNC:HGNC:27193
    See related
    Ensembl:ENSG00000151612 MIM:617962; AllianceGenome:HGNC:27193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables NuRD complex binding activity. Involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and telomere maintenance. Located in chromatin and chromosome, telomeric region. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 4.9), thyroid (RPKM 2.3) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF827 in Genome Data Viewer
    Location:
    4q31.21-q31.22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (145757627..145938823, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (149073653..149254873, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (146678779..146859975, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15732 Neighboring gene long intergenic non-protein coding RNA 2491 Neighboring gene nuclear receptor coactivator 4 pseudogene 3 Neighboring gene metabolism of cobalamin associated A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:146608063-146608617 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:146619735-146620662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146620663-146621589 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:146624094-146624783 Neighboring gene NANOG hESC enhancer GRCh37_chr4:146625046-146625631 Neighboring gene chromosome 4 open reading frame 51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15733 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146655149-146655948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146655949-146656746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:146683575-146684076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:146684077-146684576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21967 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:146729136-146730335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21969 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146746417-146746985 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:146753533-146754304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146756877-146757401 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146757402-146757925 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:146758974-146759498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:146759499-146760022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146799791-146800383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:146853271-146853772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21972 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:146875811-146877010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21974 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:146975373-146976572 Neighboring gene uncharacterized LOC105377468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21978 Neighboring gene uncharacterized LOC105377469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21979 Neighboring gene long intergenic non-protein coding RNA 1095

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (14 hits/1282 screens)

    EBI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    EBI GWAS Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog
    Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    enables NuRD complex binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in chromatin PubMed 
    located_in chromosome, telomeric region PubMed 
    is_active_in nucleus  
    part_of ribonucleoprotein complex PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306215.2NP_001293144.1  zinc finger protein 827 isoform 1

      See identical proteins and their annotated locations for NP_001293144.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents longer isoform (1).
      Source sequence(s)
      AK091130, AK094136, AK225805, BC033248, BU616184, BX112429
      Consensus CDS
      CCDS77968.1
      UniProtKB/Swiss-Prot
      B7ZL52, Q17R98, Q7Z4S7, Q8N279
      UniProtKB/TrEMBL
      A0A494C0H4
      Related
      ENSP00000421863.1, ENST00000508784.6
      Conserved Domains (4) summary
      COG5048
      Location:355443
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:376396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:819839
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:388413
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001410850.1NP_001397779.1  zinc finger protein 827 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104791, AC107212
      Consensus CDS
      CCDS93645.1
      UniProtKB/TrEMBL
      H0Y9M2
      Related
      ENSP00000424541.2, ENST00000503462.3
    3. NM_178835.5NP_849157.2  zinc finger protein 827 isoform 2

      See identical proteins and their annotated locations for NP_849157.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site that results in a shorter 3' coding region compared to variant 1. It encodes isoform 2, which has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK091130, AK094136, AK225805, BC033248, BC117407, BM557137, BU616184, BX112429
      Consensus CDS
      CCDS34072.1
      UniProtKB/TrEMBL
      A0A494C0H4
      Related
      ENSP00000368761.4, ENST00000379448.9
      Conserved Domains (4) summary
      COG5048
      Location:355443
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:376396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:819839
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:388413
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      145757627..145938823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449635.1XP_047305591.1  zinc finger protein 827 isoform X4

    2. XM_017007768.3XP_016863257.1  zinc finger protein 827 isoform X1

    3. XM_017007770.3XP_016863259.1  zinc finger protein 827 isoform X3

    4. XM_047449634.1XP_047305590.1  zinc finger protein 827 isoform X2

    5. XM_047449636.1XP_047305592.1  zinc finger protein 827 isoform X5

    6. XM_011531635.3XP_011529937.1  zinc finger protein 827 isoform X2

      See identical proteins and their annotated locations for XP_011529937.1

      Conserved Domains (4) summary
      COG5048
      Location:343431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:807827
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:11341158
      zf-H2C2_2; Zinc-finger double domain
    7. XM_017007769.2XP_016863258.1  zinc finger protein 827 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:343431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:807827
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:11341158
      zf-H2C2_2; Zinc-finger double domain
    8. XM_017007777.3XP_016863266.1  zinc finger protein 827 isoform X12

      Conserved Domains (3) summary
      sd00017
      Location:516536
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:230250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:557581
      zf-H2C2_2; Zinc-finger double domain
    9. XM_011531645.3XP_011529947.1  zinc finger protein 827 isoform X13

      Conserved Domains (3) summary
      sd00017
      Location:437457
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:151171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:478502
      zf-H2C2_2; Zinc-finger double domain
    10. XM_047449637.1XP_047305593.1  zinc finger protein 827 isoform X6

      UniProtKB/TrEMBL
      A0A494C0H4
      Related
      ENSP00000498532.1, ENST00000652097.1
    11. XM_047449638.1XP_047305594.1  zinc finger protein 827 isoform X7

      UniProtKB/TrEMBL
      A0A494C0H4
    12. XM_047449639.1XP_047305595.1  zinc finger protein 827 isoform X9

      UniProtKB/TrEMBL
      A0A494C0H4
    13. XM_017007775.3XP_016863264.1  zinc finger protein 827 isoform X8

      UniProtKB/TrEMBL
      A0A494C0H4
      Related
      ENSP00000499364.1, ENST00000656985.1
      Conserved Domains (4) summary
      COG5048
      Location:355443
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:376396
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:819839
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:388413
      zf-H2C2_2; Zinc-finger double domain
    14. XM_017007776.3XP_016863265.1  zinc finger protein 827 isoform X11

    15. XM_047449640.1XP_047305596.1  zinc finger protein 827 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      149073653..149254873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348978.1XP_054204953.1  zinc finger protein 827 isoform X4

    2. XM_054348975.1XP_054204950.1  zinc finger protein 827 isoform X1

    3. XM_054348977.1XP_054204952.1  zinc finger protein 827 isoform X3

    4. XM_054348976.1XP_054204951.1  zinc finger protein 827 isoform X2

    5. XM_054348979.1XP_054204954.1  zinc finger protein 827 isoform X5

    6. XM_054348986.1XP_054204961.1  zinc finger protein 827 isoform X12

    7. XM_054348987.1XP_054204962.1  zinc finger protein 827 isoform X13

    8. XM_054348980.1XP_054204955.1  zinc finger protein 827 isoform X6

      UniProtKB/TrEMBL
      A0A494C0H4
    9. XM_054348981.1XP_054204956.1  zinc finger protein 827 isoform X7

      UniProtKB/TrEMBL
      A0A494C0H4
    10. XM_054348983.1XP_054204958.1  zinc finger protein 827 isoform X9

      UniProtKB/TrEMBL
      A0A494C0H4
    11. XM_054348982.1XP_054204957.1  zinc finger protein 827 isoform X8

      UniProtKB/TrEMBL
      A0A494C0H4
    12. XM_054348985.1XP_054204960.1  zinc finger protein 827 isoform X11

    13. XM_054348984.1XP_054204959.1  zinc finger protein 827 isoform X10

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