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    IL20RB interleukin 20 receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 53833, updated on 10-Dec-2024

    Summary

    Official Symbol
    IL20RBprovided by HGNC
    Official Full Name
    interleukin 20 receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:6004
    See related
    Ensembl:ENSG00000174564 MIM:605621; AllianceGenome:HGNC:6004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIRS1; FNDC6; IL-20R2; IL-20RB; IL-20R-beta
    Summary
    IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
    Expression
    Biased expression in skin (RPKM 54.3) and esophagus (RPKM 20.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL20RB in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (136957983..137011085)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (139698644..139751732)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136676825..136729927)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136587915-136588414 Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 divergent transcript Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene MPRA-validated peak4840 silencer Neighboring gene NCK adaptor protein 1 Neighboring gene IL20RB antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14292 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136725903-136726404 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:136741910-136742410 Neighboring gene MPRA-validated peak4841 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:136751222-136752088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:136930163-136930662 Neighboring gene VISTA enhancer hs208 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:137038167-137039366 Neighboring gene VISTA enhancer hs209 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:137050490-137051689 Neighboring gene VISTA enhancer hs210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:137179051-137179600 Neighboring gene VISTA enhancer hs653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20598 Neighboring gene RNA, 5S ribosomal pseudogene 142 Neighboring gene MTCH2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association study of co-occurring anxiety in major depression.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC34923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-20 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-20 receptor subunit beta
    Names
    IL-20 receptor subunit beta
    fibronectin type III domain containing 6
    interleukin 20 receptor beta subunit
    interleukin-20 receptor II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144717.4NP_653318.2  interleukin-20 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_653318.2

      Status: VALIDATED

      Source sequence(s)
      AY358305, BC063696
      Consensus CDS
      CCDS3093.1
      UniProtKB/Swiss-Prot
      B4DL40, Q6P438, Q6UXL0, Q8IYY5, Q8TAJ7
      Related
      ENSP00000328133.4, ENST00000329582.9
      Conserved Domains (2) summary
      pfam01108
      Location:30124
      Tissue_fac; Tissue factor
      cl21522
      Location:136225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      136957983..137011085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512911.3XP_011511213.1  interleukin-20 receptor subunit beta isoform X2

      See identical proteins and their annotated locations for XP_011511213.1

      Conserved Domains (1) summary
      cl21522
      Location:177
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_011512910.4XP_011511212.1  interleukin-20 receptor subunit beta isoform X1

      Conserved Domains (2) summary
      pfam01108
      Location:35129
      Tissue_fac; Tissue factor
      cl21522
      Location:141230
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. XM_017006632.1XP_016862121.1  interleukin-20 receptor subunit beta isoform X2

      Conserved Domains (1) summary
      cl21522
      Location:177
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. XM_006713665.5XP_006713728.1  interleukin-20 receptor subunit beta isoform X2

      See identical proteins and their annotated locations for XP_006713728.1

      Conserved Domains (1) summary
      cl21522
      Location:177
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      139698644..139751732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346901.1XP_054202876.1  interleukin-20 receptor subunit beta isoform X2

    2. XM_054346900.1XP_054202875.1  interleukin-20 receptor subunit beta isoform X1

    3. XM_054346903.1XP_054202878.1  interleukin-20 receptor subunit beta isoform X2

    4. XM_054346902.1XP_054202877.1  interleukin-20 receptor subunit beta isoform X2