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    HCRTR1 hypocretin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 3061, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HCRTR1provided by HGNC
    Official Full Name
    hypocretin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4848
    See related
    Ensembl:ENSG00000121764 MIM:602392; AllianceGenome:HGNC:4848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OX1R; OXR1; ORXR1
    Summary
    The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See HCRTR1 in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31617689..31634492)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31475343..31490165)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32083290..32093214)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903917 Neighboring gene Sharpr-MPRA regulatory region 14090 Neighboring gene uncharacterized LOC105378626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32034359-32034860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32041927-32042647 Neighboring gene tubulointerstitial nephritis antigen like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 571 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:32070860-32072059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32080194-32080980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32083206-32083895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090464-32090964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32090965-32091465 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32110207-32110977 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene PEF1 and COL16A1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:32123622-32123860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32124291-32124792 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32131402-32131941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32131942-32132480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32133021-32133558 Neighboring gene uncharacterized LOC101929444

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release. Turunen PM, et al. Mol Pharmacol, 2012 Aug. PMID 22550093
    2. The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism. Robinson JD, et al. Cell Signal, 2015 Jul. PMID 25857454, Free PMC Article
    3. Orexin-A regulates cell apoptosis in human H295R adrenocortical cells via orexin receptor type 1 through the AKT signaling pathway. Chang X, et al. Mol Med Rep, 2015 Nov. PMID 26459696
    4. Arachidonic acid release mediated by OX1 orexin receptors. Turunen PM, et al. Br J Pharmacol, 2010 Jan. PMID 20002100, Free PMC Article
    5. Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis. El Firar A, et al. FASEB J, 2009 Dec. PMID 19661287

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.
      Title: Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.
    2. Internal and external modulation factors of the orexin system (REVIEW).
      Title: Internal and external modulation factors of the orexin system (REVIEW).
    3. Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
      Title: Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
    4. Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
      Title: Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
    5. Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.
      Title: Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.
    6. Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.
      Title: Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.
    7. Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
      Title: Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
    8. TM4 and 5 of APJ act as the interaction interface of the APJ-OX1R heterodimer, and co-internalization could be disrupted by these peptides as well.
      Title: Transmembrane peptide 4 and 5 of APJ are essential for its heterodimerization with OX1R.
    9. Study shows that homozygocity for the minor variant of the HCRTR1 gene (rs2271933, G1222A) that causes amino acid substitution (Ile408Val) was associated with aggressiveness measured with either self-reports or clinical interviews.
      Title: Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour.
    10. A significant interaction effect between GHRL rs696217 and HCRTR1 rs2271933 was found to predict the Post-traumatic stress disorder symptoms Checklist (PCL-5) total score (P = 0.007).
      Title: The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables orexin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    orexin/Hypocretin receptor type 1
    Names
    hypocretin (orexin) receptor 1
    hypocretin receptor type 1
    orexin receptor 1
    orexin receptor type 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001525.3 → NP_001516.2  orexin/Hypocretin receptor type 1

      See identical proteins and their annotated locations for NP_001516.2

      Status: REVIEWED

      Source sequence(s)
      AC114488
      Consensus CDS
      CCDS344.1
      UniProtKB/Swiss-Prot
      A8K3A6, O43613, Q9HBV6
      Related
      ENSP00000384387.2, ENST00000403528.7
      Conserved Domains (1) summary
      cd15208
      Location:47 → 369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      31617689..31634492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446605.2 → XP_024302373.1  orexin/Hypocretin receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K3A6, O43613, Q9HBV6
      Conserved Domains (1) summary
      cd15208
      Location:47 → 369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017001107.2 → XP_016856596.1  orexin/Hypocretin receptor type 1 isoform X2

      UniProtKB/TrEMBL
      A6NMV7
      Related
      ENSP00000362809.1, ENST00000373705.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      31475343..31490165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336200.1 → XP_054192175.1  orexin/Hypocretin receptor type 1 isoform X1

    2. XM_054336201.1 → XP_054192176.1  orexin/Hypocretin receptor type 1 isoform X1

    3. XM_054336202.1 → XP_054192177.1  orexin/Hypocretin receptor type 1 isoform X2

      UniProtKB/TrEMBL
      A6NMV7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43613.2 GenPept UniProtKB/Swiss-Prot:O43613

    Gene LinkOut

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